Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | HSD17B10 | Q99714 | 2/20 | 0.53 |
| ▸ | KMT2A | Q03164 | 2/20 | 0.53 |
| ▸ | GAA | P10253 | 1/20 | 0.53 |
| ▸ | HPGD | P15428 | 4/20 | 0.48 |
| ▸ | KDM4E | B2RXH2 | 2/20 | 0.44 |
| ▸ | MLYCD | O95822 | 1/20 | 0.44 |
| ▸ | HTT | P42858 | 2/20 | 0.43 |
| ▸ | LMNA | P02545 | 1/20 | 0.43 |
| ▸ | NPSR1 | Q6W5P4 | 1/20 | 0.43 |
| ▸ | POLB | P06746 | 1/20 | 0.38 |
| ▸ | TP53 | P04637 | 1/20 | 0.38 |
| ▸ | RAB9A | P51151 | 1/20 | 0.38 |
| ▸ | TAS1R3 | Q7RTX0 | 1/20 | 0.37 |
| ▸ | TAS1R1 | Q7RTX1 | 1/20 | 0.37 |
| ▸ | TAS1R2 | Q8TE23 | 1/20 | 0.37 |
| ▸ | TSHR | P16473 | 1/20 | 0.37 |
| ▸ | MEN1 | O00255 | 1/20 | 0.36 |
| ▸ | MAPK14 | Q16539 | 1/20 | 0.36 |
| ▸ | CYP2D6 | P10635 | 1/20 | 0.36 |
| ▸ | CYP2C19 | P33261 | 1/20 | 0.36 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL6241847 | 0.81 | HSD17B10 (0.53) | HSD17B10KMT2AGAAHPGDKDM4E | |
| SCHEMBL7579726 | 0.79 | MLYCD (0.40) | KMT2AHPGDMLYCDLMNANPSR1 | |
| SCHEMBL2908793 | 0.75 | HSD17B10 (0.78) | HSD17B10KMT2AGAAHPGDKDM4E | |
| SCHEMBL7195286 | 0.75 | KMT2A (0.52) | HSD17B10KMT2AGAAHPGDKDM4E | |
| SCHEMBL159472 | 0.73 | KMT2A (0.63) | HSD17B10KMT2AGAAHPGDKDM4E | |
| SCHEMBL7114941 | 0.73 | HDAC6 (0.53) | HSD17B10GAAHPGDLMNARAB9A | |
| SCHEMBL17865783 | 0.72 | MLYCD (0.73) | HSD17B10KMT2AGAAHPGDKDM4E | |
| SCHEMBL27773889 | 0.71 | KMT2A (0.61) | HSD17B10KMT2AGAAHPGDKDM4E | |
| SCHEMBL6197366 | 0.69 | CA1 (0.44) | HSD17B10KMT2AGAAHPGDKDM4E | |
| SCHEMBL1004027 | 0.69 | GAA (0.62) | HSD17B10KMT2AGAAHPGDKDM4E |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-1268463-B1 | POLYCYCLIC ARYL AND HETEROARYL SUBSTITUTED 4-PYRONES USEFUL FOR SELECTIVE INHIBITION OF THE COAGULATION CASCADE | PHARMACIA CORP (US) | 2005-02-16 | — | — | EP | claimed |