SCHEMBL6245696

SCHEMBL6245696

O=C1CN(c2ccc(Br)cc2)C(=O)N1

nearest known ligand 0.47

Predicted protein targets (top 20)

geneUniProtsupporting neighboursconfidence
▸ CRBN Q96SW2 3/20 0.46
▸ DDB1 Q16531 2/20 0.46
▸ KDM4E B2RXH2 1/20 0.43
▸ GAA P10253 1/20 0.43
▸ MAPT P10636 1/20 0.43
▸ TDP1 Q9NUW8 1/20 0.43
▸ FAAH O00519 1/20 0.41
▸ MGLL Q99685 1/20 0.41
▸ MEN1 O00255 3/20 0.39
▸ KMT2A Q03164 3/20 0.39
▸ MMP13 P45452 1/20 0.39
▸ CMA1 P23946 2/20 0.37
▸ CTSG P08311 1/20 0.37
▸ NPSR1 Q6W5P4 2/20 0.37
▸ POLB P06746 1/20 0.37
▸ HPGD P15428 1/20 0.37
▸ HSD17B10 Q99714 1/20 0.37
▸ CCNA2 P20248 1/20 0.36
▸ CDK2 P24941 1/20 0.36
▸ CCNA1 P78396 1/20 0.36

Click a target to see other patent compounds predicted against it — the reverse direction, in place.

Similar compounds — the chemically nearest patent molecules

Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.

Compoundsimilaritytop predictedshared targets
SCHEMBL8104104 0.82 CRBN (0.67) CRBNDDB1KDM4EGAAMAPT
SCHEMBL21995598 0.81 CRBN (0.71) CRBNDDB1KDM4EGAAMAPT
SCHEMBL10192194 0.80 MAPT (0.53) CRBNDDB1KDM4EGAAMAPT
SCHEMBL1421342 0.80 DDB1 (0.46) CRBNDDB1KDM4EGAAMAPT
SCHEMBL10813665 0.80 MEN1 (0.53) CRBNDDB1KDM4EGAAMAPT
SCHEMBL4539723 0.80 CRBN (0.46) CRBNDDB1KDM4EGAAMAPT
SCHEMBL746783 0.79 CRBN (0.66) CRBNDDB1KDM4EGAAMAPT
SCHEMBL1788429 0.78 MEN1 (0.58) CRBNDDB1KDM4EGAAMAPT
SCHEMBL11849406 0.78 CRBN (0.63) CRBNDDB1KDM4EGAAMAPT
Hydrochloric Acid SCHEMBL31439105 0.78 CRBN (0.63) CRBNDDB1KDM4EGAAMAPT

Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.

Patent provenance — the patents this molecule appears in, and who filed them

Claimed or disclosed in 7 patents. claimed = in the patent's claims; disclosed = body only.

PatentTitleAssigneePublishedPriorityFilingCountryStatus
WO-2025236004-A1 STAT6 INHIBITORS AND USES THEREOF KYMERA THERAPEUTICS, INC. (US) 2025-11-13 — — WO disclosed
US-8575114-B2 SGLT-2 inhibitors, methods of making them, and uses thereof ALBANY MOLECULAR RESEARCH, INC. (US) 2013-11-05 — — US disclosed
US-8575114-B2 SGLT-2 inhibitors, methods of making them, and uses thereof ALBANY MOLECULAR RESEARCH, INC. (US) 2013-11-05 — — US disclosed
US-20110237527-A1 SGLT-2 INHIBITORS, METHODS OF MAKING THEM, AND USES THEREOF ALBANY MOLECULAR RESEARCH, INC. (US) 2011-09-29 — — US disclosed
US-20110237527-A1 SGLT-2 INHIBITORS, METHODS OF MAKING THEM, AND USES THEREOF ALBANY MOLECULAR RESEARCH, INC. (US) 2011-09-29 — — US disclosed
WO-2005023232-A2 THERAPEUTIC, SCREENING AND DIAGNOSTIC METHODS BASED ON THE EFFECT OF CB1 RECEPTOR MODULATION ON LYMPHOPROLIFERATIVE DISORDERS. AFFIBODY AB (SE) 2005-03-17 — — WO disclosed
EP-0444546-B1 Hydantoin derivatives for use as hypoglycemic and/or hypolipidemic agents MOCHIDA PHARM CO LTD (JP) 1996-09-11 — — EP disclosed

Patent text — is the patent's own abstract consistent with the prediction?

For each of this compound's patents that has machine-readable text (1 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.

PatentTitleText reads most aboutPredicted target · text-rank
US-20110237527-A1 SGLT-2 INHIBITORS, METHODS OF MAKING THEM, AND USES THEREOF SLC5A2, SLC5A1, SLC10A1 CRBN 4844/4885DDB1 3019/4885KDM4E 4450/4885

“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.

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