Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | CSNK1D | P48730 | 1/20 | 0.44 |
| ▸ | MAPT | P10636 | 2/20 | 0.44 |
| ▸ | NPC1 | O15118 | 1/20 | 0.44 |
| ▸ | RAB9A | P51151 | 1/20 | 0.44 |
| ▸ | ADRB2 | P07550 | 1/20 | 0.44 |
| ▸ | ADRB1 | P08588 | 1/20 | 0.44 |
| ▸ | ADRB3 | P13945 | 1/20 | 0.44 |
| ▸ | LMNA | P02545 | 1/20 | 0.41 |
| ▸ | TP53 | P04637 | 1/20 | 0.41 |
| ▸ | SMN1; SMN2 | Q16637 | 1/20 | 0.41 |
| ▸ | LOXL2 | Q9Y4K0 | 1/20 | 0.40 |
| ▸ | KDM4E | B2RXH2 | 1/20 | 0.40 |
| ▸ | KMT2A | Q03164 | 4/20 | 0.40 |
| ▸ | MEN1 | O00255 | 3/20 | 0.40 |
| ▸ | TSHR | P16473 | 2/20 | 0.40 |
| ▸ | AKR1B1 | P15121 | 1/20 | 0.40 |
| ▸ | HDAC3 | O15379 | 2/20 | 0.39 |
| ▸ | HDAC4 | P56524 | 2/20 | 0.39 |
| ▸ | HDAC1 | Q13547 | 2/20 | 0.39 |
| ▸ | HDAC7 | Q8WUI4 | 2/20 | 0.39 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL11835830 | 0.79 | MEN1 (0.61) | CSNK1DMAPTNPC1RAB9AADRB2 | |
| SCHEMBL14310604 | 0.76 | RAB9A (0.54) | CSNK1DMAPTNPC1RAB9ALMNA | |
| SCHEMBL12561522 | 0.73 | NPC1 (0.51) | CSNK1DMAPTNPC1RAB9ALMNA | |
| SCHEMBL13342377 | 0.72 | NPC1 (0.50) | CSNK1DMAPTNPC1RAB9AADRB2 | |
| SCHEMBL13101605 | 0.72 | RAB9A (0.50) | CSNK1DMAPTNPC1RAB9ALMNA | |
| SCHEMBL31614347 | 0.72 | NPC1 (0.61) | MAPTNPC1RAB9ALMNATP53 | |
| SCHEMBL3112570 | 0.72 | NPC1 (0.61) | MAPTNPC1RAB9ALMNATP53 | |
| SCHEMBL4743256 | 0.72 | TP53 (0.54) | NPC1RAB9ALMNATP53SMN1; SMN2 | |
| SCHEMBL12210187 | 0.71 | CYP1A2 (0.55) | MAPTNPC1RAB9ALMNATP53 | |
| SCHEMBL11321089 | 0.71 | NPC1 (0.49) | MAPTNPC1RAB9ALMNATP53 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| WO-2005040162-A1 | 5-(2-ARYLACETAMIDO)ISOTHIAZOLE COMPOUNDS I | BASF AKTIENGESELLSCHAFT (DE) | 2005-05-06 | — | — | WO | disclosed |