Predicted protein targets (top 11)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | TP53 | P04637 | 1/20 | 0.32 |
| ▸ | CMA1 | P23946 | 1/20 | 0.31 |
| ▸ | AHR | P35869 | 1/20 | 0.31 |
| ▸ | CTSL | P07711 | 1/20 | 0.31 |
| ▸ | LMNA | P02545 | 2/20 | 0.30 |
| ▸ | PKM | P14618 | 1/20 | 0.30 |
| ▸ | RARA | P10276 | 1/20 | 0.30 |
| ▸ | RARB | P10826 | 1/20 | 0.30 |
| ▸ | RARG | P13631 | 1/20 | 0.30 |
| ▸ | AKR1B1 | P15121 | 1/20 | 0.30 |
| ▸ | CDK2 | P24941 | 1/20 | 0.30 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL6247872 | 0.88 | CMA1 (0.34) | CMA1AHR | |
| SCHEMBL7680544 | 0.79 | RARB (0.38) | RARARARBRARG | |
| SCHEMBL7673834 | 0.78 | KDM1A (0.45) | — | |
| SCHEMBL6246180 | 0.73 | — | — | |
| SCHEMBL1396642 | 0.71 | RARB (0.49) | TP53CMA1AHRLMNAPKM | |
| SCHEMBL7676307 | 0.71 | BACE1 (0.33) | — | |
| SCHEMBL7682166 | 0.71 | LMNA (0.39) | AHRLMNAAKR1B1 | |
| SCHEMBL6265386 | 0.68 | RARB (0.30) | RARBRARG | |
| SCHEMBL31425904 | 0.68 | CMA1 (0.33) | CMA1AHRCTSL | |
| SCHEMBL30309 | 0.67 | L3MBTL1 (0.41) | CMA1AHRLMNA |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 6 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-1354878-B1 | Tetrahydroquinoline derivatives having selective activity for retinoid x receptors | ALLERGAN INC (US) | 2005-11-23 | — | — | EP | disclosed |
| EP-1354878-A2 | Tetrahydroquinoline derivatives having selective activity for retinoid x receptors | Allergan, Inc. (US) | 2003-10-22 | — | — | EP | disclosed |
| EP-1117648-B1 | TETRAHYDROQUINOLINE DERIVATIVES HAVING SELECTIVE ACTIVITY FOR RETINOID X RECEPTORS | ALLERGAN INC (US) | 2003-08-06 | — | — | EP | disclosed |
| EP-1117648-A1 | TETRAHYDROQUINOLINE DERIVATIVES HAVING SELECTIVE ACTIVITY FOR RETINOID X RECEPTORS | Allergan Sales, Inc. (US) | 2001-07-25 | — | — | EP | disclosed |
| WO-2000020397-A1 | TETRAHYDROQUINOLINE DERIVATIVES HAVING SELECTIVE ACTIVITY FOR RETINOID X RECEPTORS | ALLERGAN SALES, INC. (US) | 2000-04-13 | — | — | WO | disclosed |
| US-6048873-A | SKIN DISORDERS | ALLERGAN SALES, INC. (US) | 2000-04-11 | — | — | US | disclosed |