Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | HPSE | Q9Y251 | 12/20 | 0.80 |
| ▸ | MAPT | P10636 | 2/20 | 0.75 |
| ▸ | RECQL | P46063 | 2/20 | 0.75 |
| ▸ | BLM | P54132 | 2/20 | 0.75 |
| ▸ | TDP1 | Q9NUW8 | 2/20 | 0.75 |
| ▸ | CACNA1B | Q00975 | 1/20 | 0.75 |
| ▸ | APBA1 | Q02410 | 1/20 | 0.75 |
| ▸ | HTT | P42858 | 2/20 | 0.64 |
| ▸ | SMN1; SMN2 | Q16637 | 2/20 | 0.64 |
| ▸ | THRB | P10828 | 1/20 | 0.64 |
| ▸ | HPGD | P15428 | 1/20 | 0.64 |
| ▸ | DUSP3 | P51452 | 1/20 | 0.64 |
| ▸ | PTPN5 | P54829 | 1/20 | 0.64 |
| ▸ | PTPN11 | Q06124 | 1/20 | 0.64 |
| ▸ | MMP2 | P08253 | 2/20 | 0.61 |
| ▸ | MMP9 | P14780 | 2/20 | 0.61 |
| ▸ | MMP8 | P22894 | 2/20 | 0.61 |
| ▸ | MMP13 | P45452 | 2/20 | 0.61 |
| ▸ | MEN1 | O00255 | 1/20 | 0.59 |
| ▸ | POLB | P06746 | 1/20 | 0.59 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL6244234 | 0.89 | HPSE (1.00) | HPSEMAPTRECQLBLMTDP1 | |
| SCHEMBL6261453 | 0.89 | HPSE (0.68) | HPSEMAPTRECQLBLMTDP1 | |
| SCHEMBL14615276 | 0.87 | MAPT (0.76) | HPSEMAPTRECQLBLMTDP1 | |
| SCHEMBL15705235 | 0.84 | HPSE (0.77) | HPSEMAPTRECQLBLMTDP1 | |
| SCHEMBL22489160 | 0.83 | FOXO1 (0.58) | HPSEMAPTRECQLBLMTDP1 | |
| SCHEMBL2246214 | 0.82 | HPSE (0.83) | HPSEMAPTRECQLBLMTDP1 | |
| SCHEMBL6513034 | 0.82 | HPSE (0.72) | HPSEMAPTRECQLBLMTDP1 | |
| SCHEMBL6265376 | 0.81 | HPSE (0.82) | HPSEMAPTRECQLBLMTDP1 | |
| SCHEMBL6248635 | 0.81 | HPSE (1.00) | HPSEMAPTRECQLBLMTDP1 | |
| SCHEMBL6246003 | 0.81 | HPSE (0.80) | HPSEMAPTRECQLBLMTDP1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| WO-2005030206-A1 | ARYL-1,3-AZOLE DERIVATIVES AND METHODS FOR INHIBITING HEPARNASE ACTIVITY | IMCLONE SYSTEMS INCORPORATED (US) | 2005-04-07 | — | — | WO | disclosed |