Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | MAPT | P10636 | 13/20 | 0.76 |
| ▸ | ALDH1A1 | P00352 | 3/20 | 0.76 |
| ▸ | KMT2A | Q03164 | 3/20 | 0.76 |
| ▸ | MEN1 | O00255 | 2/20 | 0.76 |
| ▸ | NPSR1 | Q6W5P4 | 2/20 | 0.76 |
| ▸ | SMN1; SMN2 | Q16637 | 6/20 | 0.70 |
| ▸ | TP53 | P04637 | 6/20 | 0.70 |
| ▸ | THRB | P10828 | 4/20 | 0.70 |
| ▸ | RECQL | P46063 | 2/20 | 0.70 |
| ▸ | BLM | P54132 | 2/20 | 0.70 |
| ▸ | TDP1 | Q9NUW8 | 2/20 | 0.70 |
| ▸ | HPGD | P15428 | 2/20 | 0.70 |
| ▸ | HTT | P42858 | 1/20 | 0.70 |
| ▸ | DUSP3 | P51452 | 1/20 | 0.70 |
| ▸ | PTPN5 | P54829 | 1/20 | 0.70 |
| ▸ | PTPN11 | Q06124 | 1/20 | 0.70 |
| ▸ | MAPK14 | Q16539 | 1/20 | 0.62 |
| ▸ | SMO | Q99835 | 1/20 | 0.62 |
| ▸ | CYP1A2 | P05177 | 2/20 | 0.62 |
| ▸ | CYP3A4 | P08684 | 2/20 | 0.62 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL14615274 | 0.90 | MAPT (0.80) | MAPTALDH1A1KMT2AMEN1NPSR1 | |
| SCHEMBL6246783 | 0.87 | HPSE (0.80) | MAPTKMT2AMEN1SMN1; SMN2THRB | |
| SCHEMBL14615293 | 0.81 | MAPT (0.72) | MAPTALDH1A1KMT2AMEN1NPSR1 | |
| SCHEMBL25232982 | 0.81 | MAPT (0.63) | MAPTALDH1A1KMT2AMEN1NPSR1 | |
| SCHEMBL30442877 | 0.81 | MAPT (0.63) | MAPTALDH1A1KMT2AMEN1NPSR1 | |
| SCHEMBL14615278 | 0.81 | MAPT (1.00) | MAPTALDH1A1KMT2AMEN1NPSR1 | |
| SCHEMBL22489160 | 0.80 | FOXO1 (0.58) | MAPTALDH1A1KMT2AMEN1NPSR1 | |
| SCHEMBL13679553 | 0.80 | MAPT (0.71) | MAPTALDH1A1KMT2AMEN1NPSR1 | |
| SCHEMBL14615292 | 0.80 | MAPT (0.69) | MAPTALDH1A1KMT2AMEN1NPSR1 | |
| SCHEMBL13679550 | 0.80 | MAPT (0.70) | MAPTALDH1A1KMT2AMEN1NPSR1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-8354397-B2 | Controlling cell differentiation, cell proliferation; anticancer agents | CURIS, INC. (US) | 2013-01-15 | — | — | US | disclosed |
| US-8354397-B2 | Controlling cell differentiation, cell proliferation; anticancer agents | CURIS, INC. (US) | 2013-01-15 | — | — | US | disclosed |