Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | MAPK14 | Q16539 | 8/20 | 0.49 |
| ▸ | BRAF | P15056 | 3/20 | 0.44 |
| ▸ | ABL1 | P00519 | 2/20 | 0.42 |
| ▸ | EGFR | P00533 | 2/20 | 0.42 |
| ▸ | RAF1 | P04049 | 2/20 | 0.42 |
| ▸ | LYN | P07948 | 2/20 | 0.42 |
| ▸ | EPHA2 | P29317 | 2/20 | 0.42 |
| ▸ | EPHA3 | P29320 | 2/20 | 0.42 |
| ▸ | MAPK9 | P45984 | 2/20 | 0.42 |
| ▸ | AKT1 | P31749 | 1/20 | 0.42 |
| ▸ | MAPK13 | O15264 | 3/20 | 0.41 |
| ▸ | MAPK12 | P53778 | 3/20 | 0.41 |
| ▸ | MAPK11 | Q15759 | 3/20 | 0.41 |
| ▸ | TNF | P01375 | 5/20 | 0.41 |
| ▸ | CIT | O14578 | 1/20 | 0.40 |
| ▸ | MUSK | O15146 | 1/20 | 0.40 |
| ▸ | MAP3K7 | O43318 | 1/20 | 0.40 |
| ▸ | RIPK2 | O43353 | 1/20 | 0.40 |
| ▸ | STK10 | O94804 | 1/20 | 0.40 |
| ▸ | MAP4K4 | O95819 | 1/20 | 0.40 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL4082137 | 0.91 | THRB (0.50) | MAPK14BRAFABL1EGFRRAF1 | |
| SCHEMBL4092545 | 0.89 | MAPK14 (0.61) | MAPK14BRAFABL1EGFRRAF1 | |
| SCHEMBL6249247 | 0.86 | MAPK14 (0.49) | MAPK14BRAFABL1EGFRRAF1 | |
| SCHEMBL4095891 | 0.86 | MAPK14 (0.51) | MAPK14BRAFABL1EGFRRAF1 | |
| SCHEMBL5388339 | 0.80 | MAPK14 (0.53) | MAPK14BRAFRAF1MAPK13MAPK12 | |
| SCHEMBL5384351 | 0.79 | MAPK14 (0.51) | MAPK14MAPK13MAPK12MAPK11MAPK1 | |
| SCHEMBL4092120 | 0.78 | MAPK14 (0.71) | MAPK14BRAFABL1EGFRRAF1 | |
| SCHEMBL6913451 | 0.77 | MAPK14 (0.51) | MAPK14BRAFABL1EGFRRAF1 | |
| SCHEMBL5619010 | 0.75 | MAPK14 (0.67) | MAPK14BRAFABL1EGFRRAF1 | |
| SCHEMBL6249256 | 0.75 | MAPT (0.48) | MAPK14MAPK13MAPK12MAPK11THRB |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| WO-2005044825-A1 | SILICON COMPOUNDS AND THEIR USE | AMEDIS PHARMACEUTICALS LTD. (GB) | 2005-05-19 | — | — | WO | claimed |
| WO-2005044825-A1 | SILICON COMPOUNDS AND THEIR USE | AMEDIS PHARMACEUTICALS LTD. (GB) | 2005-05-19 | — | — | WO | disclosed |