Predicted protein targets (top 14)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | MAPT | P10636 | 8/20 | 0.48 |
| ▸ | GAA | P10253 | 1/20 | 0.47 |
| ▸ | THRB | P10828 | 3/20 | 0.43 |
| ▸ | NPSR1 | Q6W5P4 | 1/20 | 0.42 |
| ▸ | L3MBTL1 | Q9Y468 | 1/20 | 0.42 |
| ▸ | MAPK13 | O15264 | 1/20 | 0.42 |
| ▸ | MAPK12 | P53778 | 1/20 | 0.42 |
| ▸ | MAPK11 | Q15759 | 1/20 | 0.42 |
| ▸ | MAPK14 | Q16539 | 1/20 | 0.42 |
| ▸ | MEN1 | O00255 | 1/20 | 0.39 |
| ▸ | KMT2A | Q03164 | 1/20 | 0.39 |
| ▸ | IDH2 | P48735 | 1/20 | 0.39 |
| ▸ | LMNA | P02545 | 3/20 | 0.39 |
| ▸ | TP53 | P04637 | 1/20 | 0.38 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL6249247 | 0.82 | MAPK14 (0.49) | THRBMAPK13MAPK12MAPK11MAPK14 | |
| SCHEMBL4082137 | 0.80 | THRB (0.50) | THRBL3MBTL1MAPK13MAPK12MAPK11 | |
| SCHEMBL6248487 | 0.75 | MAPK14 (0.49) | THRBMAPK13MAPK12MAPK11MAPK14 | |
| SCHEMBL5384351 | 0.73 | MAPK14 (0.51) | MAPTGAATHRBNPSR1L3MBTL1 | |
| SCHEMBL5388339 | 0.70 | MAPK14 (0.53) | MAPTGAATHRBNPSR1L3MBTL1 | |
| SCHEMBL6913451 | 0.68 | MAPK14 (0.51) | MAPK13MAPK12MAPK11MAPK14 | |
| SCHEMBL4095891 | 0.68 | MAPK14 (0.51) | MAPK13MAPK12MAPK11MAPK14 | |
| SCHEMBL6249544 | 0.68 | MAPK14 (0.83) | MAPK13MAPK12MAPK11MAPK14 | |
| SCHEMBL6249791 | 0.67 | MAPK14 (0.85) | MAPK13MAPK12MAPK11MAPK14 | |
| SCHEMBL14282077 | 0.62 | HRH3 (0.44) | MAPTTHRBL3MBTL1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| WO-2005044825-A1 | SILICON COMPOUNDS AND THEIR USE | AMEDIS PHARMACEUTICALS LTD. (GB) | 2005-05-19 | — | — | WO | claimed |
| WO-2005044825-A1 | SILICON COMPOUNDS AND THEIR USE | AMEDIS PHARMACEUTICALS LTD. (GB) | 2005-05-19 | — | — | WO | disclosed |