Predicted protein targets (top 6)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | NR3C1 | P04150 | 9/20 | 0.69 |
| ▸ | MMP2 | P08253 | 9/20 | 0.63 |
| ▸ | MMP9 | P14780 | 9/20 | 0.63 |
| ▸ | NR3C2 | P08235 | 2/20 | 0.61 |
| ▸ | PGR | P06401 | 1/20 | 0.61 |
| ▸ | KCNA5 | P22460 | 1/20 | 0.59 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL13888996 | 0.92 | NR3C1 (0.75) | NR3C1MMP2MMP9NR3C2PGR | |
| SCHEMBL3128293 | 0.89 | NR3C1 (0.77) | NR3C1MMP2MMP9NR3C2PGR | |
| SCHEMBL6205423 | 0.85 | NR3C1 (0.86) | NR3C1NR3C2PGR | |
| SCHEMBL5191094 | 0.82 | MMP9 (0.89) | MMP2MMP9KCNA5 | |
| SCHEMBL6720186 | 0.82 | MMP9 (0.89) | MMP2MMP9KCNA5 | |
| SCHEMBL3124795 | 0.82 | NR3C1 (0.76) | NR3C1NR3C2PGR | |
| SCHEMBL3124825 | 0.82 | NR3C1 (1.00) | NR3C1NR3C2PGR | |
| SCHEMBL3572162 | 0.80 | NR3C1 (0.69) | NR3C1MMP2MMP9NR3C2PGR | |
| SCHEMBL4647445 | 0.79 | NEK1 (0.65) | NR3C1MMP2MMP9NR3C2PGR | |
| SCHEMBL3127701 | 0.78 | NR3C1 (0.75) | NR3C1MMP2MMP9NR3C2PGR |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-1539141-A1 | -3 (SULFONAMIDOETHYL) -INDOLE DERIVATIES FOR USE AS GLUCOCORTICOID MIMETICS IN THE TREATMENT OF INFLAMMATORY, ALLERGIC AND PROLIFERATIVE DISEASES | BOEHRINGER INGELHEIM PHARMACEUTICALS INC. (US) | 2005-06-15 | — | — | EP | disclosed |
| WO-2004019935-A1 | -3 (SULFONAMIDOETHYL) -INDOLE DERIVATIES FOR USE AS GLUCOCORTICOID MIMETICS IN THE TREATMENT OF INFLAMMATORY, ALLERGIC AND PROLIFERATIVE DISEASES | BOEHRINGER INGELHEIM PHARMACEUTICALS, INC. (US) | 2004-03-11 | — | — | WO | disclosed |