Predicted protein targets (top 13)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | FYN | P06241 | 14/20 | 0.51 |
| ▸ | PIM1 | P11309 | 1/20 | 0.44 |
| ▸ | HASPIN | Q8TF76 | 1/20 | 0.38 |
| ▸ | PLAT | P00750 | 1/20 | 0.38 |
| ▸ | NTRK1 | P04629 | 1/20 | 0.38 |
| ▸ | NTRK3 | Q16288 | 1/20 | 0.38 |
| ▸ | NTRK2 | Q16620 | 1/20 | 0.38 |
| ▸ | CYP1A2 | P05177 | 1/20 | 0.38 |
| ▸ | CYP2C19 | P33261 | 1/20 | 0.38 |
| ▸ | HSD17B10 | Q99714 | 1/20 | 0.38 |
| ▸ | CLK4 | Q9HAZ1 | 1/20 | 0.38 |
| ▸ | AKT1 | P31749 | 1/20 | 0.37 |
| ▸ | AKT2 | P31751 | 1/20 | 0.37 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL625548 | 0.84 | FYN (0.52) | FYNPIM1 | |
| SCHEMBL625540 | 0.84 | FYN (0.68) | FYNHASPIN | |
| SCHEMBL625560 | 0.82 | FYN (0.50) | FYNPIM1 | |
| SCHEMBL624036 | 0.82 | FYN (0.46) | FYNPIM1HSD17B10 | |
| SCHEMBL624979 | 0.81 | ADORA2A (0.38) | PIM1PLATCYP1A2CYP2C19HSD17B10 | |
| SCHEMBL623851 | 0.77 | FYN (0.61) | FYNPIM1NTRK1NTRK3NTRK2 | |
| SCHEMBL626107 | 0.75 | PIK3CA (0.48) | FYNHASPIN | |
| SCHEMBL2255599 | 0.71 | FYN (0.53) | FYNNTRK1NTRK3NTRK2 | |
| SCHEMBL1945052 | 0.70 | FYN (0.65) | FYNHASPIN | |
| SCHEMBL624945 | 0.69 | FYN (0.49) | FYNPIM1HASPIN |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| WO-2012020217-A1 | AMINO- IMIDAZOLOTHIADIAZOLES FOR USE AS PROTEIN OR LIPID KINASE INHIBITORS | CENTRO NACIONAL DE INVESTIGACIONES ONCOLÓGICAS (CNIO) (ES) | 2012-02-16 | — | — | WO | disclosed |