Predicted protein targets (top 13)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | FYN | P06241 | 10/20 | 0.52 |
| ▸ | PIM1 | P11309 | 8/20 | 0.47 |
| ▸ | KCNH2 | Q12809 | 2/20 | 0.47 |
| ▸ | PIM3 | Q86V86 | 2/20 | 0.45 |
| ▸ | PIM2 | Q9P1W9 | 2/20 | 0.45 |
| ▸ | FLT3 | P36888 | 1/20 | 0.45 |
| ▸ | DYRK1A | Q13627 | 2/20 | 0.42 |
| ▸ | DYRK2 | Q92630 | 2/20 | 0.42 |
| ▸ | CCNA2 | P20248 | 1/20 | 0.41 |
| ▸ | CDK2 | P24941 | 1/20 | 0.41 |
| ▸ | CDK5 | Q00535 | 1/20 | 0.41 |
| ▸ | CDK5R1 | Q15078 | 1/20 | 0.41 |
| ▸ | DYRK1B | Q9Y463 | 1/20 | 0.41 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL625560 | 0.86 | FYN (0.50) | FYNPIM1KCNH2PIM3PIM2 | |
| SCHEMBL624978 | 0.84 | FYN (0.51) | FYNPIM1 | |
| SCHEMBL625540 | 0.83 | FYN (0.68) | FYN | |
| SCHEMBL623828 | 0.83 | FYN (0.46) | FYNPIM1KCNH2PIM3PIM2 | |
| SCHEMBL1945221 | 0.82 | FYN (0.76) | FYNPIM1KCNH2PIM3PIM2 | |
| SCHEMBL626107 | 0.82 | PIK3CA (0.48) | FYN | |
| SCHEMBL625549 | 0.82 | F2RL3 (0.51) | PIM1KCNH2PIM3PIM2FLT3 | |
| SCHEMBL24736880 | 0.81 | PIM1 (0.70) | FYNPIM1KCNH2PIM3PIM2 | |
| SCHEMBL29555944 | 0.81 | PIM1 (0.70) | FYNPIM1KCNH2PIM3PIM2 | |
| SCHEMBL2257233 | 0.81 | FYN (0.76) | FYNPIM1KCNH2PIM3PIM2 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| WO-2012020217-A1 | AMINO- IMIDAZOLOTHIADIAZOLES FOR USE AS PROTEIN OR LIPID KINASE INHIBITORS | CENTRO NACIONAL DE INVESTIGACIONES ONCOLÓGICAS (CNIO) (ES) | 2012-02-16 | — | — | WO | disclosed |