Predicted protein targets (top 15)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | ADORA2A | P29274 | 1/20 | 0.38 |
| ▸ | ROCK2 | O75116 | 2/20 | 0.37 |
| ▸ | F2RL3 | Q96RI0 | 4/20 | 0.37 |
| ▸ | USP30 | Q70CQ3 | 2/20 | 0.36 |
| ▸ | PIM1 | P11309 | 1/20 | 0.35 |
| ▸ | CYP1A2 | P05177 | 1/20 | 0.35 |
| ▸ | CYP2C19 | P33261 | 1/20 | 0.35 |
| ▸ | HSD17B10 | Q99714 | 1/20 | 0.35 |
| ▸ | CLK4 | Q9HAZ1 | 1/20 | 0.35 |
| ▸ | XDH | P47989 | 1/20 | 0.34 |
| ▸ | PDE4D | Q08499 | 1/20 | 0.34 |
| ▸ | TP53 | P04637 | 2/20 | 0.33 |
| ▸ | LRRK2 | Q5S007 | 1/20 | 0.33 |
| ▸ | PLAT | P00750 | 1/20 | 0.33 |
| ▸ | ALDH1A3 | P47895 | 1/20 | 0.33 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL625549 | 0.85 | F2RL3 (0.51) | F2RL3PIM1 | |
| SCHEMBL625541 | 0.85 | FYN (0.47) | F2RL3HSD17B10TP53 | |
| SCHEMBL625561 | 0.82 | PIM1 (0.49) | F2RL3PIM1XDHPLAT | |
| SCHEMBL624037 | 0.82 | CYP2D6 (0.39) | ADORA2AROCK2HSD17B10 | |
| SCHEMBL624978 | 0.81 | FYN (0.51) | PIM1CYP1A2CYP2C19HSD17B10CLK4 | |
| SCHEMBL623852 | 0.78 | FYN (0.42) | ADORA2AF2RL3CYP1A2CYP2C19HSD17B10 | |
| SCHEMBL626108 | 0.74 | MAP3K12 (0.42) | — | |
| SCHEMBL2255601 | 0.72 | ADORA2A (0.47) | ADORA2AF2RL3HSD17B10TP53ALDH1A3 | |
| SCHEMBL1945054 | 0.70 | F2RL3 (0.54) | F2RL3HSD17B10TP53 | |
| SCHEMBL624816 | 0.70 | PIM1 (0.51) | F2RL3PIM1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| WO-2012020217-A1 | AMINO- IMIDAZOLOTHIADIAZOLES FOR USE AS PROTEIN OR LIPID KINASE INHIBITORS | CENTRO NACIONAL DE INVESTIGACIONES ONCOLÓGICAS (CNIO) (ES) | 2012-02-16 | — | — | WO | disclosed |