Predicted protein targets (top 18)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | FABP7 | O15540 | 1/20 | 0.46 |
| ▸ | FABP5 | Q01469 | 1/20 | 0.46 |
| ▸ | ELANE | P08246 | 1/20 | 0.45 |
| ▸ | HPGD | P15428 | 1/20 | 0.42 |
| ▸ | CASP1 | P29466 | 1/20 | 0.42 |
| ▸ | CASP3 | P42574 | 1/20 | 0.42 |
| ▸ | CASP7 | P55210 | 1/20 | 0.42 |
| ▸ | CASP6 | P55212 | 1/20 | 0.42 |
| ▸ | CASP8 | Q14790 | 1/20 | 0.42 |
| ▸ | ALDH1A1 | P00352 | 4/20 | 0.41 |
| ▸ | CYP1A2 | P05177 | 1/20 | 0.41 |
| ▸ | NPC1 | O15118 | 1/20 | 0.41 |
| ▸ | RAB9A | P51151 | 1/20 | 0.41 |
| ▸ | SMN1; SMN2 | Q16637 | 1/20 | 0.41 |
| ▸ | GAA | P10253 | 1/20 | 0.41 |
| ▸ | PKM | P14618 | 1/20 | 0.41 |
| ▸ | MAPK1 | P28482 | 1/20 | 0.41 |
| ▸ | L3MBTL1 | Q9Y468 | 1/20 | 0.41 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL7484716 | 1.00 | FABP7 (0.46) | FABP7FABP5ELANEHPGDCASP1 | |
| SCHEMBL8466630 | 0.81 | ELANE (0.49) | FABP7FABP5ELANEHPGDCASP1 | |
| SCHEMBL2023884 | 0.81 | ELANE (0.45) | FABP7FABP5ELANEHPGDCASP1 | |
| SCHEMBL6024185 | 0.81 | ELANE (0.45) | FABP7FABP5ELANEHPGDCASP1 | |
| SCHEMBL26679383 | 0.81 | GAA (0.50) | FABP7FABP5ELANEHPGDALDH1A1 | |
| SCHEMBL6024964 | 0.81 | ELANE (0.45) | FABP7FABP5ELANEHPGDCASP1 | |
| SCHEMBL25245808 | 0.76 | ALDH1A1 (0.56) | FABP7FABP5ALDH1A1CYP1A2NPC1 | |
| SCHEMBL12986806 | 0.76 | ALDH1A1 (0.56) | FABP7FABP5ALDH1A1CYP1A2NPC1 | |
| SCHEMBL12986807 | 0.76 | ALDH1A1 (0.56) | FABP7FABP5ALDH1A1CYP1A2NPC1 | |
| SCHEMBL6250133 | 0.75 | ESR1 (0.37) | ALDH1A1CYP1A2SMN1; SMN2GAAMAPK1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 8 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-0856315-B1 | PROTEIN-FARNESYLTRANSFERASE INHIBITORS IN COMBINATION WITH HMGCOA-REDUCTASE-INHIBITORS FOR THE TREATMENT OF AIDS | BANYU PHARMA CO LTD (JP) | 2005-08-24 | — | — | EP | disclosed |
| US-6083985-A | LOVASTATIN, SIMVASTATIN, PRAVASTATIN OR FLUVASTATIN OR DERIVATIVES DECREASES FARNESYL PYROPHOSPHATE IN VIVO; PROTEIN-FARNESYLTRANSFERASE INHIBITOR | BANYU PHARMACEUTICAL CO., LTD. (JP) | 2000-07-04 | — | — | US | disclosed |
| EP-0776884-B1 | SUBSTITUTED AMIDE DERIVATIVE | BANYU PHARMA CO LTD (JP) | 2000-01-05 | — | — | EP | disclosed |
| EP-0856315-A1 | MEDICINAL COMPOSITION | BANYU PHARMACEUTICAL CO., LTD. (JP) | 1998-08-05 | — | — | EP | disclosed |
| EP-0836383-A1 | COMBINATIONS OF INHIBITORS OF FARNESYL-PROTEIN TRANSFERASE | Merck & Co., Inc. (US) | 1998-04-22 | — | — | EP | disclosed |
| US-5643958-A | ANTITUMOR | BANYU PHARMACEUTICAL CO., LTD. (JP) | 1997-07-01 | — | — | US | disclosed |
| EP-0776884-A1 | SUBSTITUTED AMIDE DERIVATIVE | BANYU PHARMACEUTICAL CO., LTD. (JP) | 1997-06-04 | — | — | EP | disclosed |
| WO-1997001275-A1 | COMBINATIONS OF INHIBITORS OF FARNESYL-PROTEIN TRANSFERASE | MERCK & CO., INC. (US) | 1997-01-16 | — | — | WO | disclosed |