Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | ALDH1A1 | P00352 | 12/20 | 0.43 |
| ▸ | POLB | P06746 | 2/20 | 0.43 |
| ▸ | L3MBTL1 | Q9Y468 | 3/20 | 0.43 |
| ▸ | MAPT | P10636 | 6/20 | 0.40 |
| ▸ | TSHR | P16473 | 3/20 | 0.40 |
| ▸ | MAPK1 | P28482 | 2/20 | 0.40 |
| ▸ | HPGD | P15428 | 1/20 | 0.40 |
| ▸ | KDM4E | B2RXH2 | 1/20 | 0.40 |
| ▸ | KMT2A | Q03164 | 5/20 | 0.39 |
| ▸ | CDYL2 | Q8N8U2 | 1/20 | 0.39 |
| ▸ | CDYL | Q9Y232 | 1/20 | 0.39 |
| ▸ | CDY1; CDY1B | Q9Y6F8 | 1/20 | 0.39 |
| ▸ | GAA | P10253 | 4/20 | 0.38 |
| ▸ | MEN1 | O00255 | 4/20 | 0.38 |
| ▸ | ALPL | P05186 | 3/20 | 0.38 |
| ▸ | ALPG | P10696 | 3/20 | 0.38 |
| ▸ | ALPI | P09923 | 2/20 | 0.38 |
| ▸ | TDP1 | Q9NUW8 | 1/20 | 0.38 |
| ▸ | USP2 | O75604 | 1/20 | 0.38 |
| ▸ | ALOX15 | P16050 | 1/20 | 0.38 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL6251199 | 0.67 | L3MBTL1 (0.47) | ALDH1A1POLBL3MBTL1MAPTTSHR | |
| SCHEMBL4565781 | 0.66 | GAA (0.46) | ALDH1A1POLBL3MBTL1MAPTTSHR | |
| SCHEMBL10565837 | 0.65 | L3MBTL1 (0.58) | ALDH1A1POLBL3MBTL1MAPTTSHR | |
| SCHEMBL28393168 | 0.65 | L3MBTL1 (0.58) | ALDH1A1POLBL3MBTL1MAPTTSHR | |
| SCHEMBL25502419 | 0.65 | GAA (0.58) | ALDH1A1POLBL3MBTL1MAPTTSHR | |
| SCHEMBL9255582 | 0.65 | L3MBTL1 (0.45) | ALDH1A1POLBL3MBTL1MAPTTSHR | |
| SCHEMBL28227422 | 0.62 | ALDH1A1 (0.45) | ALDH1A1POLBL3MBTL1MAPTTSHR | |
| SCHEMBL8669241 | 0.62 | ALDH1A1 (0.45) | ALDH1A1POLBL3MBTL1MAPTTSHR | |
| SCHEMBL12659470 | 0.62 | L3MBTL1 (0.61) | ALDH1A1POLBL3MBTL1MAPTTSHR | |
| SCHEMBL7614600 | 0.62 | L3MBTL1 (0.54) | ALDH1A1POLBL3MBTL1MAPTTSHR |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 4 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-1354878-B1 | Tetrahydroquinoline derivatives having selective activity for retinoid x receptors | ALLERGAN INC (US) | 2005-11-23 | — | — | EP | disclosed |
| EP-1354878-A2 | Tetrahydroquinoline derivatives having selective activity for retinoid x receptors | Allergan, Inc. (US) | 2003-10-22 | — | — | EP | disclosed |
| EP-1117648-B1 | TETRAHYDROQUINOLINE DERIVATIVES HAVING SELECTIVE ACTIVITY FOR RETINOID X RECEPTORS | ALLERGAN INC (US) | 2003-08-06 | — | — | EP | disclosed |
| US-6048873-A | SKIN DISORDERS | ALLERGAN SALES, INC. (US) | 2000-04-11 | — | — | US | disclosed |