Predicted protein targets (top 17)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | PIK3CA | P42336 | 9/20 | 0.49 |
| ▸ | CKS1B | P61024 | 1/20 | 0.42 |
| ▸ | SKP1 | P63208 | 1/20 | 0.42 |
| ▸ | SKP2 | Q13309 | 1/20 | 0.42 |
| ▸ | RIPK1 | Q13546 | 1/20 | 0.40 |
| ▸ | KCNH2 | Q12809 | 7/20 | 0.39 |
| ▸ | SYK | P43405 | 1/20 | 0.39 |
| ▸ | ITGB2 | P05107 | 1/20 | 0.39 |
| ▸ | ICAM1 | P05362 | 1/20 | 0.39 |
| ▸ | ITGAL | P20701 | 1/20 | 0.39 |
| ▸ | FLT3 | P36888 | 2/20 | 0.38 |
| ▸ | KIT | P10721 | 1/20 | 0.38 |
| ▸ | PIM1 | P11309 | 1/20 | 0.38 |
| ▸ | CDK7 | P50613 | 1/20 | 0.38 |
| ▸ | PIM3 | Q86V86 | 1/20 | 0.38 |
| ▸ | HASPIN | Q8TF76 | 1/20 | 0.38 |
| ▸ | PIM2 | Q9P1W9 | 1/20 | 0.38 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL624990 | 0.95 | PIK3CA (0.47) | PIK3CARIPK1KCNH2SYKITGB2 | |
| SCHEMBL625187 | 0.88 | PIK3CA (0.47) | PIK3CACKS1BSKP1SKP2KCNH2 | |
| SCHEMBL625132 | 0.87 | CKS1B (0.42) | PIK3CACKS1BSKP1SKP2SYK | |
| SCHEMBL626891 | 0.86 | PIK3CA (0.49) | PIK3CAHASPIN | |
| SCHEMBL626893 | 0.86 | PIK3CA (0.49) | PIK3CAHASPIN | |
| SCHEMBL625746 | 0.84 | PIK3CA (0.54) | PIK3CAKCNH2FLT3KITPIM1 | |
| SCHEMBL625421 | 0.84 | PIK3CA (0.52) | PIK3CARIPK1KCNH2FLT3KIT | |
| SCHEMBL624967 | 0.83 | PIK3CA (0.55) | PIK3CAKCNH2FLT3KITPIM1 | |
| SCHEMBL624991 | 0.83 | SYK (0.45) | PIK3CACKS1BSKP1SKP2SYK | |
| SCHEMBL625620 | 0.82 | PIK3CA (0.56) | PIK3CAKCNH2FLT3KITPIM1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| WO-2012020215-A1 | AMINO- IMIDAZOLOTHIADIAZOLES FOR USE AS PROTEIN OR LIPID KINASE INHIBITORS | CENTRO NACIONAL DE INVESTIGACIONES ONCOLÓGICAS (CNIO) (ES) | 2012-02-16 | — | — | WO | disclosed |