Predicted protein targets (top 14)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | CKS1B | P61024 | 1/20 | 0.42 |
| ▸ | SKP1 | P63208 | 1/20 | 0.42 |
| ▸ | SKP2 | Q13309 | 1/20 | 0.42 |
| ▸ | SYK | P43405 | 1/20 | 0.41 |
| ▸ | MAPT | P10636 | 9/20 | 0.41 |
| ▸ | PIK3CA | P42336 | 2/20 | 0.41 |
| ▸ | THRB | P10828 | 4/20 | 0.41 |
| ▸ | MAP3K12 | Q12852 | 3/20 | 0.41 |
| ▸ | RET | P07949 | 1/20 | 0.40 |
| ▸ | ITGB2 | P05107 | 1/20 | 0.40 |
| ▸ | ICAM1 | P05362 | 1/20 | 0.40 |
| ▸ | ITGAL | P20701 | 1/20 | 0.40 |
| ▸ | GAA | P10253 | 1/20 | 0.39 |
| ▸ | RXFP1 | Q9HBX9 | 1/20 | 0.39 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL624991 | 0.95 | SYK (0.45) | CKS1BSKP1SKP2SYKPIK3CA | |
| SCHEMBL625188 | 0.88 | CKS1B (0.44) | CKS1BSKP1SKP2MAPTPIK3CA | |
| SCHEMBL625131 | 0.87 | PIK3CA (0.49) | CKS1BSKP1SKP2SYKPIK3CA | |
| SCHEMBL626892 | 0.86 | PIK3CA (0.42) | PIK3CAMAP3K12 | |
| SCHEMBL626106 | 0.84 | THRB (0.49) | MAPTPIK3CATHRBGAARXFP1 | |
| SCHEMBL625422 | 0.84 | PIK3CA (0.42) | CKS1BSKP1SKP2MAPTPIK3CA | |
| SCHEMBL624968 | 0.84 | MAP3K12 (0.43) | MAPTPIK3CATHRBMAP3K12GAA | |
| SCHEMBL625621 | 0.83 | MAP3K12 (0.46) | MAPTPIK3CAMAP3K12 | |
| SCHEMBL624990 | 0.82 | PIK3CA (0.47) | SYKPIK3CAITGB2ICAM1ITGAL | |
| SCHEMBL626464 | 0.82 | MAPT (0.47) | MAPTPIK3CATHRBMAP3K12GAA |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| WO-2012020215-A1 | AMINO- IMIDAZOLOTHIADIAZOLES FOR USE AS PROTEIN OR LIPID KINASE INHIBITORS | CENTRO NACIONAL DE INVESTIGACIONES ONCOLÓGICAS (CNIO) (ES) | 2012-02-16 | — | — | WO | disclosed |