Predicted protein targets (top 13)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | PIK3CA | P42336 | 9/20 | 0.47 |
| ▸ | CKS1B | P61024 | 1/20 | 0.44 |
| ▸ | SKP1 | P63208 | 1/20 | 0.44 |
| ▸ | SKP2 | Q13309 | 1/20 | 0.44 |
| ▸ | FGFR3 | P22607 | 1/20 | 0.41 |
| ▸ | KDR | P35968 | 1/20 | 0.41 |
| ▸ | SIRT2 | Q8IXJ6 | 1/20 | 0.40 |
| ▸ | SIRT1 | Q96EB6 | 1/20 | 0.40 |
| ▸ | SIRT3 | Q9NTG7 | 1/20 | 0.40 |
| ▸ | ACACB | O00763 | 2/20 | 0.38 |
| ▸ | ACACA | Q13085 | 2/20 | 0.38 |
| ▸ | KCNH2 | Q12809 | 6/20 | 0.38 |
| ▸ | FLT3 | P36888 | 2/20 | 0.38 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL625131 | 0.88 | PIK3CA (0.49) | PIK3CACKS1BSKP1SKP2KCNH2 | |
| SCHEMBL625188 | 0.88 | CKS1B (0.44) | PIK3CACKS1BSKP1SKP2SIRT2 | |
| SCHEMBL624990 | 0.85 | PIK3CA (0.47) | PIK3CAKCNH2 | |
| SCHEMBL626168 | 0.84 | PIK3CA (0.53) | PIK3CASIRT2SIRT1SIRT3KCNH2 | |
| SCHEMBL624411 | 0.82 | PIK3CA (0.54) | PIK3CAKCNH2FLT3 | |
| SCHEMBL625421 | 0.82 | PIK3CA (0.52) | PIK3CAKCNH2FLT3 | |
| SCHEMBL625746 | 0.82 | PIK3CA (0.54) | PIK3CAKCNH2FLT3 | |
| SCHEMBL625034 | 0.81 | PIM1 (0.54) | CKS1BSKP1SKP2FGFR3KDR | |
| SCHEMBL625620 | 0.80 | PIK3CA (0.56) | PIK3CAKCNH2FLT3 | |
| SCHEMBL626463 | 0.80 | PIK3CA (0.53) | PIK3CAKCNH2 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| WO-2012020215-A1 | AMINO- IMIDAZOLOTHIADIAZOLES FOR USE AS PROTEIN OR LIPID KINASE INHIBITORS | CENTRO NACIONAL DE INVESTIGACIONES ONCOLÓGICAS (CNIO) (ES) | 2012-02-16 | — | — | WO | disclosed |