Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | LMNA | P02545 | 3/20 | 0.54 |
| ▸ | ALDH1A1 | P00352 | 2/20 | 0.54 |
| ▸ | SLC22A2 | O15244 | 1/20 | 0.54 |
| ▸ | SLC22A1 | O15245 | 1/20 | 0.54 |
| ▸ | TSHR | P16473 | 1/20 | 0.54 |
| ▸ | ACHE | P22303 | 1/20 | 0.54 |
| ▸ | MAPK1 | P28482 | 1/20 | 0.54 |
| ▸ | CYP2C19 | P33261 | 1/20 | 0.54 |
| ▸ | BLM | P54132 | 2/20 | 0.53 |
| ▸ | PMP22 | Q01453 | 1/20 | 0.53 |
| ▸ | TMEM97 | Q5BJF2 | 1/20 | 0.52 |
| ▸ | SIGMAR1 | Q99720 | 1/20 | 0.52 |
| ▸ | NFKB1 | P19838 | 1/20 | 0.51 |
| ▸ | KCNH2 | Q12809 | 1/20 | 0.51 |
| ▸ | HDAC3 | O15379 | 1/20 | 0.51 |
| ▸ | HDAC1 | Q13547 | 1/20 | 0.51 |
| ▸ | POLB | P06746 | 2/20 | 0.50 |
| ▸ | CD274 | Q9NZQ7 | 1/20 | 0.50 |
| ▸ | CYP3A4 | P08684 | 1/20 | 0.50 |
| ▸ | THRB | P10828 | 1/20 | 0.50 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL25812119 | 0.88 | LMNA (0.54) | LMNAALDH1A1SLC22A2SLC22A1TSHR | |
| SCHEMBL14537512 | 0.81 | HDAC3 (0.56) | ALDH1A1CYP2C19HDAC3HDAC1CD274 | |
| SCHEMBL30547775 | 0.77 | MAOB (0.59) | HDAC3HDAC1CD274MAOBCHRNA7 | |
| SCHEMBL1995821 | 0.77 | MAOB (0.59) | HDAC3HDAC1CD274MAOBCHRNA7 | |
| SCHEMBL15219324 | 0.76 | ALDH1A1 (0.59) | LMNAALDH1A1SLC22A2SLC22A1TSHR | |
| SCHEMBL25811248 | 0.76 | MAPT (0.62) | LMNAALDH1A1SLC22A2SLC22A1TSHR | |
| SCHEMBL13426153 | 0.75 | LMNA (0.58) | LMNAALDH1A1SLC22A2SLC22A1TSHR | |
| SCHEMBL2442620 | 0.75 | LMNA (0.58) | LMNAALDH1A1SLC22A2SLC22A1TSHR | |
| SCHEMBL11919098 | 0.75 | LMNA (0.58) | LMNAALDH1A1SLC22A2SLC22A1TSHR | |
| SCHEMBL22043064 | 0.75 | ALDH1A1 (0.74) | LMNAALDH1A1SLC22A2SLC22A1TSHR |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-1565455-A1 | INDOLYL PYRAZINONE DERIVATIVES USEFUL FOR TREATING HYPER-PROLIFERATIVE DISORDERS AND DISEASES ASSOCIATED WITH ANGIOGENESIS | Bayer Pharmaceuticals Corporation (US) | 2005-08-24 | — | — | EP | disclosed |
| WO-2004043950-A1 | INDOLYL PYRAZINONE DERIVATIVES USEFUL FOR TREATING HYPER-PROLIFERATIVE DISORDERS AND DISEASES ASSOCIATED WITH ANGIOGENESIS | BAYER PHARMACEUTICALS CORPORATION (US) | 2004-05-27 | — | — | WO | disclosed |