Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | SMN1; SMN2 | Q16637 | 2/20 | 0.68 |
| ▸ | ALDH1A1 | P00352 | 1/20 | 0.68 |
| ▸ | MAPT | P10636 | 1/20 | 0.68 |
| ▸ | KCNQ3 | O43525 | 16/20 | 0.53 |
| ▸ | KCNQ2 | O43526 | 16/20 | 0.53 |
| ▸ | F12 | P00748 | 1/20 | 0.47 |
| ▸ | NPC1 | O15118 | 2/20 | 0.42 |
| ▸ | RAB9A | P51151 | 2/20 | 0.42 |
| ▸ | GMNN | O75496 | 1/20 | 0.42 |
| ▸ | USP2 | O75604 | 1/20 | 0.42 |
| ▸ | LMNA | P02545 | 1/20 | 0.42 |
| ▸ | TP53 | P04637 | 1/20 | 0.42 |
| ▸ | CYP1A2 | P05177 | 1/20 | 0.42 |
| ▸ | CYP3A4 | P08684 | 1/20 | 0.42 |
| ▸ | ADORA3 | P0DMS8 | 1/20 | 0.42 |
| ▸ | GAA | P10253 | 1/20 | 0.42 |
| ▸ | CYP2C9 | P11712 | 1/20 | 0.42 |
| ▸ | PKM | P14618 | 1/20 | 0.42 |
| ▸ | ALOX15 | P16050 | 1/20 | 0.42 |
| ▸ | NFKB1 | P19838 | 1/20 | 0.42 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL9780233 | 0.82 | SMN1; SMN2 (0.46) | SMN1; SMN2ALDH1A1MAPTKCNQ3KCNQ2 | |
| SCHEMBL4813428 | 0.81 | MAPT (1.00) | SMN1; SMN2ALDH1A1MAPTF12NPC1 | |
| Hydrochloric Acid SCHEMBL9780209 | 0.80 | SMN1; SMN2 (0.43) | SMN1; SMN2ALDH1A1MAPTKCNQ3KCNQ2 | |
| SCHEMBL8793858 | 0.79 | SMN1; SMN2 (0.43) | SMN1; SMN2ALDH1A1MAPTKCNQ3KCNQ2 | |
| SCHEMBL9422899 | 0.79 | KCNQ3 (0.43) | SMN1; SMN2ALDH1A1MAPTKCNQ3KCNQ2 | |
| SCHEMBL9757465 | 0.79 | SMN1; SMN2 (0.43) | SMN1; SMN2ALDH1A1MAPTKCNQ3KCNQ2 | |
| SCHEMBL1393108 | 0.79 | SMN1; SMN2 (0.43) | SMN1; SMN2ALDH1A1MAPTKCNQ3KCNQ2 | |
| SCHEMBL9757530 | 0.78 | KCNQ3 (0.43) | SMN1; SMN2ALDH1A1MAPTKCNQ3KCNQ2 | |
| Bromide SCHEMBL9422839 | 0.78 | KCNQ3 (0.43) | SMN1; SMN2ALDH1A1MAPTKCNQ3KCNQ2 | |
| SCHEMBL8651427 | 0.78 | KCNQ3 (0.43) | SMN1; SMN2ALDH1A1MAPTKCNQ3KCNQ2 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 4 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-1569641-A2 | PROPARGYL-TRIFLUOROMETHOXY-AMINO-BENZOTHIAZOLE DERIVATIVES | Teva Pharmaceutical Industries Limited (IL) | 2005-09-07 | — | — | EP | disclosed |
| US-20040176430-A1 | Propargyl-trifluoromethoxy-amino-benzothiazole derivatives | TEVA PHARMACEUTICAL INDUSTRIES, LTD. (IL) | 2004-09-09 | — | — | US | disclosed |
| WO-2004047756-A2 | PROPARGYL-TRIFLUOROMETHOXY-AMINO-BENZOTHIAZOLE DERIVATIVES | TEVA PHARMACEUTICAL INDUSTRIES, LTD. (IL) | 2004-06-10 | — | — | WO | disclosed |
| US-4980356-A | ANTICONVULSANTS; ANTISPASMODIC AGENTS; MUSCULAR AND NERVOUS SYSTEMS DISORDERS | RHONE-POULENC SANTE (FR) | 1990-12-25 | — | — | US | disclosed |
Patent text — is the patent's own abstract consistent with the prediction?
For each of this compound's patents that has machine-readable text (1 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.
| Patent | Title | Text reads most about | Predicted target · text-rank |
|---|---|---|---|
| US-20040176430-A1 | Propargyl-trifluoromethoxy-amino-benzothiazole derivatives | CLIC1, CCR1, CCR4 | SMN1; SMN2 302/4885ALDH1A1 1733/4885MAPT 2025/4885 |
“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.