Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | SMN1; SMN2 | Q16637 | 2/20 | 0.36 |
| ▸ | LMNA | P02545 | 1/20 | 0.36 |
| ▸ | MAPK1 | P28482 | 1/20 | 0.36 |
| ▸ | HTT | P42858 | 1/20 | 0.36 |
| ▸ | ALDH1A1 | P00352 | 1/20 | 0.35 |
| ▸ | CYP3A4 | P08684 | 1/20 | 0.34 |
| ▸ | GAA | P10253 | 1/20 | 0.34 |
| ▸ | CYP2C9 | P11712 | 1/20 | 0.34 |
| ▸ | CYP2C19 | P33261 | 1/20 | 0.34 |
| ▸ | IGF1R | P08069 | 2/20 | 0.34 |
| ▸ | AR | P10275 | 1/20 | 0.32 |
| ▸ | KMT2A | Q03164 | 1/20 | 0.32 |
| ▸ | MMP1 | P03956 | 4/20 | 0.32 |
| ▸ | MMP9 | P14780 | 4/20 | 0.32 |
| ▸ | MMP13 | P45452 | 4/20 | 0.32 |
| ▸ | HSD11B1 | P28845 | 4/20 | 0.32 |
| ▸ | HRH3 | Q9Y5N1 | 2/20 | 0.32 |
| ▸ | CHRM2 | P08172 | 1/20 | 0.32 |
| ▸ | HTR1A | P08908 | 1/20 | 0.32 |
| ▸ | ADRA2A | P08913 | 1/20 | 0.32 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL2939613 | 0.71 | IGF1R (0.42) | SMN1; SMN2LMNAMAPK1HTTIGF1R | |
| SCHEMBL6172121 | 0.68 | AR (0.44) | SMN1; SMN2LMNAMAPK1HTTALDH1A1 | |
| SCHEMBL6178355 | 0.68 | AR (0.44) | SMN1; SMN2LMNAMAPK1HTTALDH1A1 | |
| SCHEMBL2932324 | 0.67 | LMNA (0.38) | SMN1; SMN2LMNAMAPK1HTTIGF1R | |
| SCHEMBL2933712 | 0.67 | IGF1R (0.57) | SMN1; SMN2LMNAMAPK1HTTIGF1R | |
| SCHEMBL2940999 | 0.67 | IGF1R (0.42) | SMN1; SMN2LMNAMAPK1HTTIGF1R | |
| SCHEMBL4028165 | 0.65 | AR (0.53) | SMN1; SMN2LMNAMAPK1HTTCYP3A4 | |
| Trifluoroacetic Acid SCHEMBL17558354 | 0.64 | AR (0.40) | MAPK1ALDH1A1CYP3A4GAACYP2C9 | |
| SCHEMBL2940648 | 0.64 | IGF1R (0.57) | SMN1; SMN2LMNAMAPK1HTTIGF1R | |
| SCHEMBL6175564 | 0.64 | LMNA (0.39) | SMN1; SMN2LMNAMAPK1HTTALDH1A1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-1599464-A2 | NOVEL CYCLIC UREA DERIVATIVES, PREPARATION METHOD THEREOF AND PHARMACEUTICAL USE OF SAME AS KINASE INHIBITORS | Aventis Pharma S.A. (FR) | 2005-11-30 | — | — | EP | disclosed |
| WO-2004070050-A2 | CYCLIC UREA DERIVATIVES, PREPARATION METHOD THEREOF AND PHARMACEUTICAL USE OF SAME AS KINASE INHIBITORS | AVENTIS PHARMA S.A. (FR) | 2004-08-19 | — | — | WO | disclosed |