SCHEMBL6252098

SCHEMBL6252098

CC[Si]1(C)C(c2ccc3ccccc3n2)=C(c2ccccc2)C(c2ccccc2)=C1c1ccc2ccccc2n1

nearest known ligand 0.41

Predicted protein targets (top 20)

geneUniProtsupporting neighboursconfidence
RAB9A P51151 12/20 0.41
NPC1 O15118 11/20 0.41
AR P10275 2/20 0.41
CYP3A4 P08684 2/20 0.41
CYP1A2 P05177 2/20 0.41
CYP2D6 P10635 1/20 0.41
CYP2C9 P11712 1/20 0.41
CYP2C19 P33261 1/20 0.41
KDM4E B2RXH2 8/20 0.41
SMN1; SMN2 Q16637 7/20 0.41
ALDH1A1 P00352 6/20 0.41
NFKB1 P19838 1/20 0.41
NFKB2 Q00653 1/20 0.41
RELA Q04206 1/20 0.41
MEN1 O00255 4/20 0.41
KMT2A Q03164 4/20 0.41
MAPT P10636 7/20 0.40
HSD17B10 Q99714 4/20 0.40
TP53 P04637 3/20 0.40
PKM P14618 3/20 0.40

Click a target to see other patent compounds predicted against it — the reverse direction, in place.

Similar compounds — the chemically nearest patent molecules

Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.

Compoundsimilaritytop predictedshared targets
SCHEMBL6256122 0.90 RAB9A (0.42) RAB9ANPC1ARCYP3A4CYP1A2
SCHEMBL6252312 0.87 RAB9A (0.42) RAB9ANPC1ARCYP3A4CYP1A2
SCHEMBL6256309 0.81 NPC1 (0.47) RAB9ANPC1KDM4ESMN1; SMN2ALDH1A1
SCHEMBL6253014 0.80 RAB9A (0.52) RAB9ANPC1CYP3A4CYP1A2CYP2D6
SCHEMBL6257084 0.80 KDM4E (0.36) KDM4ESMN1; SMN2ALDH1A1MEN1KMT2A
SCHEMBL6255337 0.78 CYP1A1 (0.41) RAB9ANPC1ARCYP1A2CYP2C9
SCHEMBL6256111 0.78 CCR1 (0.44) RAB9ANPC1CYP3A4CYP2D6CYP2C9
SCHEMBL6253395 0.77 CYP1A2 (0.43) RAB9ANPC1CYP1A2SMN1; SMN2ALDH1A1
SCHEMBL6255928 0.77 RAB9A (0.45) RAB9ANPC1ARCYP3A4CYP1A2
SCHEMBL6257290 0.75 NPC1 (0.43) RAB9ANPC1CYP1A2KDM4E

Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.

Patent provenance — the patents this molecule appears in, and who filed them

Claimed or disclosed in 6 patents. claimed = in the patent's claims; disclosed = body only.

PatentTitleAssigneePublishedPriorityFilingCountryStatus
EP-1143538-B1 Organic electroluminescent element containing a silacyclopentadiene derivative CHISSO CORP (JP) 2005-09-14 EP disclosed
EP-0754691-B1 Silacyclopentadiene derivatives and an organic electroluminescent element obtained by using the silacyclopentadiene derivative CHISSO CORP (JP) 2003-11-19 EP disclosed
EP-1143538-A1 Silacyclopentadiene derivatives and an organic electroluminescent element obtained by using the silacyclopentadiene derivative Chisso Corporation (JP) 2001-10-10 EP disclosed
US-6051319-A Silacyclopentadiene derivatives and an organic electroluminescent element obtained by using the silacyclopentadiene derivative CHISSO CORPORATION (JP) 2000-04-18 US disclosed
US-5986121-A Silacyclopentadiene derivatives and an organic electroluminescent element obtained by using the silacyclopentadiene derivative CHISSO CORPORATION (JP) 1999-11-16 US disclosed
EP-0754691-A2 Silacyclopentadiene derivatives and an organic electroluminescent element obtained by using the silacyclopentadiene derivative CHISSO CORPORATION (JP) 1997-01-22 EP disclosed