SCHEMBL6252801

SCHEMBL6252801

CC[Si]1(CC)C(c2ncccn2)=C(c2ccccc2)C(c2ccccc2)=C1c1ncccn1

nearest known ligand 0.34

Predicted protein targets (top 20)

geneUniProtsupporting neighboursconfidence
ALDH1A1 P00352 2/20 0.33
TSHR P16473 2/20 0.33
CYP2A6 P11509 1/20 0.33
CLK4 Q9HAZ1 2/20 0.33
DYRK1A Q13627 1/20 0.33
CTNNB1 P35222 1/20 0.33
WNT3A P56704 1/20 0.33
MTOR P42345 1/20 0.32
ADK P55263 1/20 0.32
NISCH Q9Y2I1 1/20 0.32
SLC6A7 Q99884 1/20 0.32
ADRB2 P07550 1/20 0.32
NPC1 O15118 2/20 0.31
RAB9A P51151 2/20 0.31
SMN1; SMN2 Q16637 2/20 0.31
NFKB1 P19838 1/20 0.31
NFKB2 Q00653 1/20 0.31
RELA Q04206 1/20 0.31
MAPK1 P28482 1/20 0.31
HPGDS O60760 1/20 0.31

Click a target to see other patent compounds predicted against it — the reverse direction, in place.

Similar compounds — the chemically nearest patent molecules

Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.

Compoundsimilaritytop predictedshared targets
SCHEMBL6254886 0.84 SMN1; SMN2 (0.37) ALDH1A1TSHRCYP2A6CLK4DYRK1A
SCHEMBL6266204 0.83 CYP1A2 (0.44) ALDH1A1TSHRCYP2A6NPC1RAB9A
SCHEMBL6253373 0.81 ALDH1A1 (0.35) ALDH1A1SMN1; SMN2MAPTL3MBTL1
SCHEMBL6252096 0.79 CYP2A6 (0.36) ALDH1A1TSHRCYP2A6CLK4DYRK1A
SCHEMBL6255652 0.79 NOTUM (0.48) ALDH1A1NPC1RAB9ASMN1; SMN2MAPT
SCHEMBL6255925 0.79 CTNNB1 (0.36) ALDH1A1TSHRCYP2A6CLK4DYRK1A
SCHEMBL10018833 0.77 SMN1; SMN2 (0.38) ALDH1A1RAB9ASMN1; SMN2MAPK1MAPT
SCHEMBL15975777 0.77 SMN1; SMN2 (0.51) ALDH1A1TSHRNPC1RAB9ASMN1; SMN2
SCHEMBL6253891 0.77 CYP1A2 (0.44) NPC1RAB9ASMN1; SMN2MAPTL3MBTL1
SCHEMBL8332179 0.76 CYP2A6 (0.45) ALDH1A1CYP2A6NPC1RAB9ASMN1; SMN2

Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.

Patent provenance — the patents this molecule appears in, and who filed them

Claimed or disclosed in 6 patents. claimed = in the patent's claims; disclosed = body only.

PatentTitleAssigneePublishedPriorityFilingCountryStatus
EP-1143538-B1 Organic electroluminescent element containing a silacyclopentadiene derivative CHISSO CORP (JP) 2005-09-14 EP disclosed
EP-0754691-B1 Silacyclopentadiene derivatives and an organic electroluminescent element obtained by using the silacyclopentadiene derivative CHISSO CORP (JP) 2003-11-19 EP disclosed
EP-1143538-A1 Silacyclopentadiene derivatives and an organic electroluminescent element obtained by using the silacyclopentadiene derivative Chisso Corporation (JP) 2001-10-10 EP disclosed
US-6051319-A Silacyclopentadiene derivatives and an organic electroluminescent element obtained by using the silacyclopentadiene derivative CHISSO CORPORATION (JP) 2000-04-18 US disclosed
US-5986121-A Silacyclopentadiene derivatives and an organic electroluminescent element obtained by using the silacyclopentadiene derivative CHISSO CORPORATION (JP) 1999-11-16 US disclosed
EP-0754691-A2 Silacyclopentadiene derivatives and an organic electroluminescent element obtained by using the silacyclopentadiene derivative CHISSO CORPORATION (JP) 1997-01-22 EP disclosed