SCHEMBL6255652

SCHEMBL6255652

CC[Si]1(CC)C(c2ccncc2)=C(c2ccccc2)C(c2ccccc2)=C1c1ccncc1

nearest known ligand 0.48

Predicted protein targets (top 20)

geneUniProtsupporting neighboursconfidence
NOTUM Q6P988 1/20 0.48
NPC1 O15118 2/20 0.39
RAB9A P51151 2/20 0.39
ATAD2 Q6PL18 1/20 0.39
NPY5R Q15761 1/20 0.38
MAPK11 Q15759 3/20 0.37
MAPK14 Q16539 3/20 0.37
CSNK1D P48730 2/20 0.37
MAPK13 O15264 1/20 0.36
MAPK12 P53778 1/20 0.36
NSD3 Q9BZ95 1/20 0.36
SLC6A2 P23975 1/20 0.35
SLC6A4 P31645 1/20 0.35
SLC6A3 Q01959 1/20 0.35
SMN1; SMN2 Q16637 3/20 0.35
KMT2A Q03164 2/20 0.35
KDM4E B2RXH2 1/20 0.35
AR P10275 1/20 0.35
S1PR1 P21453 1/20 0.35
MEN1 O00255 1/20 0.35

Click a target to see other patent compounds predicted against it — the reverse direction, in place.

Similar compounds — the chemically nearest patent molecules

Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.

Compoundsimilaritytop predictedshared targets
SCHEMBL6253373 0.89 ALDH1A1 (0.35) SLC6A4SMN1; SMN2KMT2AMAPTALDH1A1
SCHEMBL10018833 0.85 SMN1; SMN2 (0.38) RAB9ASMN1; SMN2KDM4EMAPTLMNA
SCHEMBL6252562 0.84 NOTUM (0.47) NOTUMNPC1RAB9AATAD2NPY5R
SCHEMBL8332179 0.83 CYP2A6 (0.45) NPC1RAB9ANPY5RSMN1; SMN2KMT2A
SCHEMBL6252798 0.81 ATM (0.48) HSD17B10PIM1
SCHEMBL6256991 0.80 RAB9A (0.39) NPC1RAB9ASMN1; SMN2KMT2AKDM4E
SCHEMBL6256695 0.79 NOTUM (0.54) NOTUMNPC1RAB9AATAD2NPY5R
SCHEMBL6252801 0.79 ALDH1A1 (0.33) NPC1RAB9ASMN1; SMN2MAPTLMNA
SCHEMBL6256567 0.79 PTGS1 (0.40) MAPK14KMT2AMEN1MAPTALDH1A1
SCHEMBL6254829 0.79 NOTUM (0.48) NOTUMNPC1RAB9AATAD2NPY5R

Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.

Patent provenance — the patents this molecule appears in, and who filed them

Claimed or disclosed in 8 patents. claimed = in the patent's claims; disclosed = body only.

PatentTitleAssigneePublishedPriorityFilingCountryStatus
EP-1143538-B1 Organic electroluminescent element containing a silacyclopentadiene derivative CHISSO CORP (JP) 2005-09-14 EP disclosed
EP-0754691-B1 Silacyclopentadiene derivatives and an organic electroluminescent element obtained by using the silacyclopentadiene derivative CHISSO CORP (JP) 2003-11-19 EP disclosed
EP-1143538-A1 Silacyclopentadiene derivatives and an organic electroluminescent element obtained by using the silacyclopentadiene derivative Chisso Corporation (JP) 2001-10-10 EP disclosed
EP-1034190-A1 POLYMERIZATION CATALYST FOR OLEFIN MONOMERS LG CHEMICAL LIMITED (KR) 2000-09-13 EP disclosed
US-6051319-A Silacyclopentadiene derivatives and an organic electroluminescent element obtained by using the silacyclopentadiene derivative CHISSO CORPORATION (JP) 2000-04-18 US disclosed
US-5986121-A Silacyclopentadiene derivatives and an organic electroluminescent element obtained by using the silacyclopentadiene derivative CHISSO CORPORATION (JP) 1999-11-16 US disclosed
WO-1999026985-A1 POLYMERIZATION CATALYST FOR OLEFIN MONOMERS LG CHEMICAL LTD. (KR) 1999-06-03 WO disclosed
EP-0754691-A2 Silacyclopentadiene derivatives and an organic electroluminescent element obtained by using the silacyclopentadiene derivative CHISSO CORPORATION (JP) 1997-01-22 EP disclosed