Known targets — ChEMBL curated mechanism
ACHECHRM1CHRM3CHRNA1CHRNB1CHRNDCHRNECHRNG
The experimentally established mechanism targets of Biphenyl. The predicted profile below is derived independently by chemical similarity — agreement is a validation signal, a miss is honest.
Predicted protein targets (top 10)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | PTPN1 | P18031 | 1/20 | 0.47 |
| ▸ | NAAA | Q02083 | 1/20 | 0.44 |
| ▸ | ITGB1 | P05556 | 1/20 | 0.43 |
| ▸ | ITGA4 | P13612 | 1/20 | 0.43 |
| ▸ | S1PR2 | O95136 | 1/20 | 0.43 |
| ▸ | S1PR1 | P21453 | 1/20 | 0.43 |
| ▸ | S1PR3 | Q99500 | 1/20 | 0.43 |
| ▸ | PTGES | O14684 | 2/20 | 0.43 |
| ▸ | ALOX5 | P09917 | 2/20 | 0.43 |
| ▸ | EPHX2 | P34913 | 1/20 | 0.43 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| Biphenyl SCHEMBL27876466 | 0.98 | PTPN1 (0.48) | PTPN1NAAAITGB1ITGA4S1PR2 | |
| Biphenyl SCHEMBL27692896 | 0.91 | HPGD (0.43) | PTPN1ALOX5 | |
| Benzene SCHEMBL27649746 | 0.87 | EPHX2 (0.51) | S1PR2S1PR1S1PR3EPHX2 | |
| Benzene SCHEMBL112147 | 0.87 | EPHX2 (0.51) | S1PR2S1PR1S1PR3EPHX2 | |
| Benzene SCHEMBL11150225 | 0.87 | EPHX2 (0.51) | S1PR2S1PR1S1PR3EPHX2 | |
| Benzene SCHEMBL28758814 | 0.87 | EPHX2 (0.51) | S1PR2S1PR1S1PR3EPHX2 | |
| Benzene SCHEMBL27649739 | 0.87 | EPHX2 (0.51) | S1PR2S1PR1S1PR3EPHX2 | |
| Phenol SCHEMBL10879720 | 0.86 | ESR1 (0.47) | NAAAS1PR2S1PR1S1PR3EPHX2 | |
| Triphenylphosphine Oxide SCHEMBL29152235 | 0.85 | PTPN1 (0.44) | PTPN1NAAAS1PR2S1PR1S1PR3 | |
| Toluene SCHEMBL29170928 | 0.84 | NAAA (0.42) | NAAAS1PR2S1PR1S1PR3EPHX2 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 3 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-1035436-B1 | Resist pattern formation method | JSR CORP (JP) | 2005-09-07 | — | — | EP | disclosed |
| US-6403288-B1 | COATING WITH COPOLYMER COMPRISING HYDROXYSTYRENE DERIVATIVE MONOMER HAVING ACID DISSOCIABLE GROUP; EXPOSURE TO RADIATION; DEVELOPMENT | JSR CORPORATION (JP) | 2002-06-11 | — | — | US | disclosed |
| EP-1035436-A1 | Resist pattern formation method | JSR Corporation (JP) | 2000-09-13 | — | — | EP | disclosed |