Predicted protein targets (top 9)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | KMT2A | Q03164 | 1/20 | 0.43 |
| ▸ | GPR183 | P32249 | 9/20 | 0.42 |
| ▸ | ALOX5 | P09917 | 1/20 | 0.40 |
| ▸ | TDP1 | Q9NUW8 | 1/20 | 0.38 |
| ▸ | APP | P05067 | 1/20 | 0.37 |
| ▸ | CHRM1 | P11229 | 1/20 | 0.37 |
| ▸ | MCHR1 | Q99705 | 1/20 | 0.37 |
| ▸ | GFER | P55789 | 1/20 | 0.36 |
| ▸ | ALDH1A1 | P00352 | 1/20 | 0.36 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL6250333 | 0.99 | GPR183 (0.43) | KMT2AGPR183ALOX5APPGFER | |
| SCHEMBL6258306 | 0.85 | DPP4 (0.45) | GPR183GFERALDH1A1 | |
| SCHEMBL666992 | 0.83 | APP (0.49) | KMT2AGPR183APPGFERALDH1A1 | |
| SCHEMBL6228346 | 0.77 | KMT2A (0.43) | KMT2AGPR183ALOX5TDP1ALDH1A1 | |
| SCHEMBL14737095 | 0.73 | GRM3 (0.44) | KMT2AGPR183ALDH1A1 | |
| Fluorobenzene SCHEMBL28159220 | 0.71 | HPGD (0.55) | KMT2AALOX5ALDH1A1 | |
| SCHEMBL16151536 | 0.70 | HPGD (0.65) | KMT2AGPR183ALDH1A1 | |
| SCHEMBL4554708 | 0.69 | NPSR1 (0.55) | KMT2AAPPGFERALDH1A1 | |
| SCHEMBL22031721 | 0.69 | GRM5 (0.46) | KMT2ATDP1ALDH1A1 | |
| SCHEMBL1840511 | 0.68 | FABP4 (0.46) | GPR183GFER |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-1517894-A1 | N-BENZYL-3-PHENYL-3-HETEROCYCLYL-PROPIONAMIDE COMPOUNDS AS TACHYKININ ANTAGONISTS AND/OR SEROTONIN REUPTAKE INHIBITORS | GLAXO GROUP LIMITED (GB) | 2005-03-30 | — | — | EP | disclosed |
| WO-2004005255-A1 | N-BENZYL-3-PHENYL-3-HETEROCYCLYL-PROPIONAMIDE COMPOUNDS AS TACHYKININ AND/ OR SEROTONIN REUPTAKE INHIBITORS | GLAXO GROUP LIMITED (GB) | 2004-01-15 | — | — | WO | disclosed |