Predicted protein targets (top 10)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | DPP4 | P27487 | 13/20 | 0.45 |
| ▸ | DPP8 | Q6V1X1 | 9/20 | 0.45 |
| ▸ | DPP7 | Q9UHL4 | 10/20 | 0.41 |
| ▸ | DPP9 | Q86TI2 | 4/20 | 0.39 |
| ▸ | KCNH2 | Q12809 | 2/20 | 0.37 |
| ▸ | ALDH1A1 | P00352 | 1/20 | 0.37 |
| ▸ | SMN1; SMN2 | Q16637 | 1/20 | 0.37 |
| ▸ | GPR183 | P32249 | 2/20 | 0.37 |
| ▸ | RAB9A | P51151 | 1/20 | 0.36 |
| ▸ | GFER | P55789 | 1/20 | 0.36 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL6250333 | 0.86 | GPR183 (0.43) | GPR183RAB9AGFER | |
| SCHEMBL6254331 | 0.85 | KMT2A (0.43) | ALDH1A1GPR183GFER | |
| SCHEMBL14737095 | 0.76 | GRM3 (0.44) | ALDH1A1SMN1; SMN2GPR183RAB9A | |
| SCHEMBL666992 | 0.76 | APP (0.49) | ALDH1A1SMN1; SMN2GPR183RAB9AGFER | |
| SCHEMBL15011796 | 0.71 | DPP4 (0.43) | DPP4DPP8DPP7DPP9ALDH1A1 | |
| SCHEMBL17143263 | 0.71 | DPP4 (0.43) | DPP4DPP8DPP7DPP9ALDH1A1 | |
| SCHEMBL4099888 | 0.67 | RAB9A (0.57) | ALDH1A1SMN1; SMN2RAB9A | |
| SCHEMBL31686146 | 0.66 | POLB (0.48) | DPP4DPP8DPP7DPP9RAB9A | |
| SCHEMBL1657048 | 0.65 | AR (0.50) | DPP4DPP7 | |
| SCHEMBL25010712 | 0.64 | DPP4 (0.42) | DPP4DPP8DPP7DPP9ALDH1A1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-1517894-A1 | N-BENZYL-3-PHENYL-3-HETEROCYCLYL-PROPIONAMIDE COMPOUNDS AS TACHYKININ ANTAGONISTS AND/OR SEROTONIN REUPTAKE INHIBITORS | GLAXO GROUP LIMITED (GB) | 2005-03-30 | — | — | EP | disclosed |
| WO-2004005255-A1 | N-BENZYL-3-PHENYL-3-HETEROCYCLYL-PROPIONAMIDE COMPOUNDS AS TACHYKININ AND/ OR SEROTONIN REUPTAKE INHIBITORS | GLAXO GROUP LIMITED (GB) | 2004-01-15 | — | — | WO | disclosed |