Predicted protein targets (top 17)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | MAPT | P10636 | 1/20 | 0.58 |
| ▸ | CYP1A2 | P05177 | 1/20 | 0.51 |
| ▸ | CYP2D6 | P10635 | 1/20 | 0.51 |
| ▸ | NPC1 | O15118 | 3/20 | 0.50 |
| ▸ | RAB9A | P51151 | 3/20 | 0.50 |
| ▸ | TAAR1 | Q96RJ0 | 2/20 | 0.47 |
| ▸ | HRH1 | P35367 | 1/20 | 0.47 |
| ▸ | KCNH2 | Q12809 | 1/20 | 0.45 |
| ▸ | SCN5A | Q14524 | 1/20 | 0.45 |
| ▸ | SCN9A | Q15858 | 1/20 | 0.45 |
| ▸ | ALDH1A1 | P00352 | 2/20 | 0.44 |
| ▸ | HRH3 | Q9Y5N1 | 1/20 | 0.43 |
| ▸ | CACNA1B | Q00975 | 1/20 | 0.43 |
| ▸ | NR3C2 | P08235 | 1/20 | 0.43 |
| ▸ | PLK1 | P53350 | 1/20 | 0.42 |
| ▸ | LMNA | P02545 | 1/20 | 0.42 |
| ▸ | MAOB | P27338 | 1/20 | 0.42 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL2131530 | 0.84 | L3MBTL1 (0.59) | MAPTNPC1RAB9AKCNH2SCN5A | |
| SCHEMBL624671 | 0.82 | TAAR1 (0.54) | MAPTCYP1A2CYP2D6TAAR1ALDH1A1 | |
| SCHEMBL8867729 | 0.80 | CYP1A2 (0.56) | MAPTCYP1A2CYP2D6RAB9ATAAR1 | |
| SCHEMBL2750398 | 0.80 | CYP1A2 (0.65) | CYP1A2CYP2D6TAAR1HRH1KCNH2 | |
| SCHEMBL1760766 | 0.79 | CYP1A2 (0.69) | CYP1A2CYP2D6TAAR1HRH1KCNH2 | |
| SCHEMBL29572974 | 0.79 | CYP1A2 (0.69) | CYP1A2CYP2D6TAAR1HRH1KCNH2 | |
| Bromide SCHEMBL6565773 | 0.77 | CYP1A2 (0.67) | CYP1A2CYP2D6TAAR1HRH1KCNH2 | |
| Ammonia Solution, Strong SCHEMBL21752109 | 0.77 | CYP1A2 (0.67) | CYP1A2CYP2D6TAAR1HRH1KCNH2 | |
| Bromide SCHEMBL7912525 | 0.77 | CYP1A2 (0.67) | CYP1A2CYP2D6TAAR1HRH1KCNH2 | |
| Hydrochloric Acid SCHEMBL10981614 | 0.77 | CYP1A2 (0.67) | CYP1A2CYP2D6TAAR1HRH1KCNH2 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 4 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-2771322-A2 | NOVEL TRPV3 MODULATORS | AbbVie Inc. (US) | 2014-09-03 | — | — | EP | disclosed |
| EP-2603490-A1 | NOVEL TRPV3 MODULATORS | AbbVie Inc. (US) | 2013-06-19 | — | — | EP | disclosed |
| WO-2013062964-A2 | NOVEL TRPV3 MODULATORS | ABBVIE INC. (US) | 2013-05-02 | — | — | WO | disclosed |
| WO-2012019315-A1 | NOVEL TRPV3 MODULATORS | ABBOTT LABORATORIES (US) | 2012-02-16 | — | — | WO | disclosed |