SCHEMBL8867729

SCHEMBL8867729

Fc1ccc(CCc2ccccn2)cc1

nearest known ligand 0.60

Predicted protein targets (top 20)

geneUniProtsupporting neighboursconfidence
CYP1A2 P05177 1/20 0.56
CYP2D6 P10635 1/20 0.56
HRH1 P35367 2/20 0.52
RAB9A P51151 1/20 0.51
HTT P42858 2/20 0.50
KDM4E B2RXH2 2/20 0.50
MAPT P10636 1/20 0.50
SMN1; SMN2 Q16637 1/20 0.50
KCNA5 P22460 1/20 0.50
GRM2 Q14416 1/20 0.49
ABCB1 P08183 1/20 0.49
HTR1A P08908 1/20 0.49
DRD2 P14416 1/20 0.49
HTR2A P28223 1/20 0.49
HTR2C P28335 1/20 0.49
KCNH2 Q12809 1/20 0.49
HRH3 Q9Y5N1 1/20 0.47
LMNA P02545 1/20 0.46
TAAR1 Q96RJ0 1/20 0.46
ALDH1A1 P00352 1/20 0.46

Click a target to see other patent compounds predicted against it — the reverse direction, in place.

Similar compounds — the chemically nearest patent molecules

Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.

Compoundsimilaritytop predictedshared targets
SCHEMBL29572974 0.84 CYP1A2 (0.69) CYP1A2CYP2D6HRH1SMN1; SMN2ABCB1
SCHEMBL1760766 0.84 CYP1A2 (0.69) CYP1A2CYP2D6HRH1SMN1; SMN2ABCB1
SCHEMBL3233668 0.82 L3MBTL1 (0.65) HRH1RAB9AHTTKDM4EMAPT
Bromide SCHEMBL6565773 0.82 CYP1A2 (0.67) CYP1A2CYP2D6HRH1SMN1; SMN2ABCB1
Hydrochloric Acid SCHEMBL10981614 0.82 CYP1A2 (0.67) CYP1A2CYP2D6HRH1KDM4EABCB1
Bromide SCHEMBL7912525 0.82 CYP1A2 (0.67) CYP1A2CYP2D6HRH1SMN1; SMN2ABCB1
Ammonia Solution, Strong SCHEMBL21752109 0.82 CYP1A2 (0.67) CYP1A2CYP2D6HRH1SMN1; SMN2ABCB1
SCHEMBL29485678 0.81 HRH1 (0.73) CYP1A2CYP2D6HRH1MAPTSMN1; SMN2
SCHEMBL230753 0.81 HRH1 (0.73) CYP1A2CYP2D6HRH1MAPTSMN1; SMN2
SCHEMBL7355640 0.81 NPSR1 (0.64) CYP1A2CYP2D6HRH1KDM4EABCB1

Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.

Patent provenance — the patents this molecule appears in, and who filed them

Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.

PatentTitleAssigneePublishedPriorityFilingCountryStatus
US-5700806-A FARNESYL PROTEIN TRANSFERASE ENZYME INHIBITOR, ANTITUMOR AGENTS SCHERING CORPORATION (US) 1997-12-23 US disclosed