SCHEMBL6254449

SCHEMBL6254449

O=C(O)c1ccccc1CN1C=Cc2ccccc2S1

nearest known ligand 0.41

Predicted protein targets (top 18)

geneUniProtsupporting neighboursconfidence
FOLH1 Q04609 2/20 0.41
BRD4 O60885 4/20 0.39
ALDH1A1 P00352 3/20 0.39
TSHR P16473 1/20 0.38
HIF1A Q16665 1/20 0.37
KDM4E B2RXH2 1/20 0.36
SIRT1 Q96EB6 1/20 0.36
ALOX15 P16050 2/20 0.36
CYP2D6 P10635 1/20 0.35
CYP2C9 P11712 1/20 0.35
CYP2C19 P33261 1/20 0.35
GRIK3 Q13003 1/20 0.35
HSD17B10 Q99714 1/20 0.35
MEN1 O00255 1/20 0.35
KMT2A Q03164 1/20 0.35
HMGB1 P09429 1/20 0.35
TP53 P04637 1/20 0.35
HTT P42858 1/20 0.35

Click a target to see other patent compounds predicted against it — the reverse direction, in place.

Similar compounds — the chemically nearest patent molecules

Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.

Compoundsimilaritytop predictedshared targets
SCHEMBL7182054 0.68 P2RX4 (0.33) TSHRMEN1KMT2A
SCHEMBL28462723 0.67 PTGS1 (0.56) FOLH1BRD4ALDH1A1TSHRHIF1A
SCHEMBL31751956 0.66 KMT2A (0.56) FOLH1ALDH1A1HIF1AMEN1KMT2A
SCHEMBL1251436 0.66 KMT2A (0.56) FOLH1ALDH1A1HIF1AMEN1KMT2A
SCHEMBL69352 0.64 TSHR (0.68) FOLH1ALDH1A1TSHRHIF1AKDM4E
SCHEMBL70392 0.64 FOLH1 (0.76) FOLH1ALDH1A1TSHRHIF1AKDM4E
SCHEMBL30365583 0.64 FOLH1 (0.76) FOLH1ALDH1A1TSHRHIF1AKDM4E
SCHEMBL7433040 0.64 ALDH1A1 (0.67) FOLH1BRD4ALDH1A1TSHRHIF1A
SCHEMBL23453516 0.63 TP53 (0.59) FOLH1ALDH1A1TSHRHIF1AKDM4E
SCHEMBL30879601 0.63 HIF1A (0.57) FOLH1ALDH1A1TSHRHIF1AKDM4E

Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.

Patent provenance — the patents this molecule appears in, and who filed them

Claimed or disclosed in 6 patents. claimed = in the patent's claims; disclosed = body only.

PatentTitleAssigneePublishedPriorityFilingCountryStatus
EP-1534274-A1 COMBINATION OF AN ALLOSTERIC ALKYNE INHIBITOR OF MATRIX METALLOPROTEINASE-13 WITH CELECOXIB OR VALDECOXIB Warner-Lambert Company LLC (US) 2005-06-01 EP disclosed
EP-1531904-A1 COMBINATION OF AN ALLOSTERIC INHIBITOR OF MATRIX METALLOPROTEINASE-13 WITH A SELECTIVE INHIBITOR OF CYCLOOXYGENASE-2 THAT IS NOT CELECOXIB OR VALDECOXIB Warner-Lambert Company LLC (US) 2005-05-25 EP disclosed
EP-1525030-A1 COMBINATION OF AN ALLOSTERIC ALKYNE INHIBITOR OF MATRIX METALLOPROTEINASE-13 WITH A SELECTIVE INHIBITOR OF CYCLOOXYGENASE-2 THAT IS NOT CELECOXIB OR VALDECOXIB Warner-Lambert Company LLC (US) 2005-04-27 EP disclosed
WO-2004007024-A1 COMBINATION OF AN ALLOSTERIC INHIBITOR OF MATRIX METALLOPROTEINASE-13 WITH A SELECTIVE INHIBITOR OF CYCLOOXYGENASE-2 THAT IS NOT CELECOXIB OR VALDECOXIB WARNER-LAMBERT COMPANY LLC (US) 2004-01-22 WO disclosed
WO-2004006914-A1 COMBINATION OF AN ALLOSTERIC ALKYNE INHIBITOR OF MATRIX METALLOPROTEINASE-13 WITH CELECOXIB OR VALDECOXIB WARNER-LAMBERT COMPANY LLC (US) 2004-01-22 WO disclosed
WO-2004007025-A1 COMBINATION OF AN ALLOSTERIC ALKYNE INHIBITOR OF MATRIX METALLOPROTEINASE-13 WITH A SELECTIVE INHIBITOR OF CYCLOOXYGENASE-2 THAT IS NOT CELECOXIB OR VALDECOXIB WARNER-LAMBERT COMPANY LLC (US) 2004-01-22 WO disclosed