Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | PIM1 | P11309 | 17/20 | 0.56 |
| ▸ | PIM3 | Q86V86 | 5/20 | 0.47 |
| ▸ | KCNH2 | Q12809 | 5/20 | 0.47 |
| ▸ | PIM2 | Q9P1W9 | 5/20 | 0.47 |
| ▸ | FLT3 | P36888 | 4/20 | 0.47 |
| ▸ | CYP1A2 | P05177 | 1/20 | 0.44 |
| ▸ | CYP3A4 | P08684 | 1/20 | 0.44 |
| ▸ | CYP2D6 | P10635 | 1/20 | 0.44 |
| ▸ | CYP2C9 | P11712 | 1/20 | 0.44 |
| ▸ | CYP2C19 | P33261 | 1/20 | 0.44 |
| ▸ | GAK | O14976 | 1/20 | 0.44 |
| ▸ | STK10 | O94804 | 1/20 | 0.44 |
| ▸ | YES1 | P07947 | 1/20 | 0.44 |
| ▸ | RET | P07949 | 1/20 | 0.44 |
| ▸ | PDGFRB | P09619 | 1/20 | 0.44 |
| ▸ | CSNK2A2 | P19784 | 1/20 | 0.44 |
| ▸ | ACVR1 | Q04771 | 1/20 | 0.44 |
| ▸ | PKN1 | Q16512 | 1/20 | 0.44 |
| ▸ | HASPIN | Q8TF76 | 1/20 | 0.44 |
| ▸ | SIK2 | Q9H0K1 | 1/20 | 0.44 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL1945253 | 0.94 | PIM1 (0.47) | PIM1PIM3KCNH2PIM2FLT3 | |
| SCHEMBL1944168 | 0.90 | PIM1 (0.55) | PIM1PIM3KCNH2PIM2FLT3 | |
| SCHEMBL624816 | 0.89 | PIM1 (0.51) | PIM1PIM3KCNH2PIM2FLT3 | |
| SCHEMBL623883 | 0.86 | F2RL3 (0.52) | PIM1PIM2FLT3F2RL3 | |
| SCHEMBL624879 | 0.86 | PIM1 (0.50) | PIM1PIM3KCNH2PIM2FLT3 | |
| Hydrochloric Acid SCHEMBL625023 | 0.86 | PIM1 (0.45) | PIM1PIM3KCNH2PIM2FLT3 | |
| SCHEMBL624837 | 0.85 | PIM1 (0.47) | PIM1PIM3KCNH2PIM2FLT3 | |
| SCHEMBL624042 | 0.85 | PIM1 (0.48) | PIM1PIM3KCNH2PIM2FLT3 | |
| SCHEMBL625517 | 0.83 | PIM1 (0.47) | PIM1PIM3KCNH2PIM2FLT3 | |
| SCHEMBL624533 | 0.83 | PIM1 (0.53) | PIM1PIM3KCNH2PIM2FLT3 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| WO-2012020217-A1 | AMINO- IMIDAZOLOTHIADIAZOLES FOR USE AS PROTEIN OR LIPID KINASE INHIBITORS | CENTRO NACIONAL DE INVESTIGACIONES ONCOLÓGICAS (CNIO) (ES) | 2012-02-16 | — | — | WO | disclosed |