Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | TDP1 | Q9NUW8 | 2/20 | 0.46 |
| ▸ | TSHR | P16473 | 3/20 | 0.43 |
| ▸ | SMN1; SMN2 | Q16637 | 3/20 | 0.43 |
| ▸ | KMT2A | Q03164 | 3/20 | 0.40 |
| ▸ | MEN1 | O00255 | 1/20 | 0.40 |
| ▸ | POLB | P06746 | 3/20 | 0.38 |
| ▸ | THRB | P10828 | 1/20 | 0.36 |
| ▸ | PKM | P14618 | 2/20 | 0.36 |
| ▸ | ATM | Q13315 | 1/20 | 0.36 |
| ▸ | F2 | P00734 | 1/20 | 0.36 |
| ▸ | PRSS1 | P07477 | 1/20 | 0.36 |
| ▸ | PRSS2 | P07478 | 1/20 | 0.36 |
| ▸ | PRSS3 | P35030 | 1/20 | 0.36 |
| ▸ | ALPL | P05186 | 1/20 | 0.36 |
| ▸ | ALPI | P09923 | 1/20 | 0.36 |
| ▸ | NPC1 | O15118 | 1/20 | 0.36 |
| ▸ | GAA | P10253 | 1/20 | 0.36 |
| ▸ | MAPK1 | P28482 | 1/20 | 0.36 |
| ▸ | RAB9A | P51151 | 1/20 | 0.36 |
| ▸ | NFKBIA | P25963 | 1/20 | 0.36 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL10482176 | 0.77 | TDP1 (0.58) | TDP1TSHRSMN1; SMN2KMT2AMEN1 | |
| SCHEMBL27609739 | 0.76 | TDP1 (0.56) | TDP1TSHRSMN1; SMN2KMT2AMEN1 | |
| SCHEMBL23575094 | 0.75 | TDP1 (0.47) | TDP1TSHRSMN1; SMN2KMT2AMEN1 | |
| SCHEMBL22288597 | 0.75 | TDP1 (0.47) | TDP1TSHRSMN1; SMN2KMT2AMEN1 | |
| SCHEMBL22445346 | 0.75 | TDP1 (0.47) | TDP1TSHRSMN1; SMN2KMT2AMEN1 | |
| SCHEMBL27568731 | 0.73 | PRMT5 (0.58) | TDP1TSHRSMN1; SMN2KMT2AMEN1 | |
| SCHEMBL27548998 | 0.73 | PRMT5 (0.58) | TDP1TSHRSMN1; SMN2KMT2AMEN1 | |
| SCHEMBL5082690 | 0.72 | KMT2A (0.41) | TDP1KMT2AMEN1POLBTHRB | |
| SCHEMBL10700952 | 0.72 | TDP1 (0.64) | TDP1TSHRSMN1; SMN2KMT2AMEN1 | |
| SCHEMBL9356245 | 0.72 | TDP1 (0.64) | TDP1TSHRSMN1; SMN2KMT2AMEN1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-1521757-A1 | NOVEL TRICYCLIC SPIROPIPERIDINES OR SPIROPYRROLIDINES | AstraZeneca AB (SE) | 2005-04-13 | — | — | EP | disclosed |
| WO-2004005295-A1 | NOVEL TRICYCLIC SPIROPIPERIDINES OR SPIROPYRROLIDINES | ASTRAZENECA AB (SE) | 2004-01-15 | — | — | WO | disclosed |