Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | PTGER1 | P34995 | 1/20 | 0.46 |
| ▸ | DHODH | Q02127 | 1/20 | 0.43 |
| ▸ | CYP1A2 | P05177 | 4/20 | 0.43 |
| ▸ | ADORA2A | P29274 | 1/20 | 0.41 |
| ▸ | ADORA2B | P29275 | 1/20 | 0.41 |
| ▸ | CYP2C9 | P11712 | 3/20 | 0.41 |
| ▸ | CYP2C19 | P33261 | 3/20 | 0.41 |
| ▸ | SMN1; SMN2 | Q16637 | 1/20 | 0.41 |
| ▸ | CGAS | Q8N884 | 1/20 | 0.40 |
| ▸ | GABRA2 | P47869 | 1/20 | 0.40 |
| ▸ | GABRB2 | P47870 | 1/20 | 0.40 |
| ▸ | ALDH1A1 | P00352 | 3/20 | 0.40 |
| ▸ | NR1H2 | P55055 | 1/20 | 0.40 |
| ▸ | NR1H3 | Q13133 | 1/20 | 0.40 |
| ▸ | KDM4E | B2RXH2 | 1/20 | 0.40 |
| ▸ | GAA | P10253 | 1/20 | 0.40 |
| ▸ | HPGD | P15428 | 1/20 | 0.40 |
| ▸ | P2RX7 | Q99572 | 2/20 | 0.39 |
| ▸ | NPC1 | O15118 | 1/20 | 0.39 |
| ▸ | RAB9A | P51151 | 1/20 | 0.39 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL6255264 | 0.87 | PTGER1 (0.51) | PTGER1DHODHCYP1A2ADORA2AADORA2B | |
| SCHEMBL6257997 | 0.79 | CYP1A2 (0.62) | CYP1A2CYP2C9CYP2C19SMN1; SMN2GABRA2 | |
| SCHEMBL19864297 | 0.76 | ALDH1A1 (0.55) | CYP1A2CYP2C9CYP2C19SMN1; SMN2GABRA2 | |
| SCHEMBL6259295 | 0.75 | MEN1 (0.54) | DHODHALDH1A1KDM4ERAB9AMEN1 | |
| SCHEMBL8823133 | 0.75 | HSD11B1 (0.52) | PTGER1DHODHALDH1A1KDM4EP2RX7 | |
| SCHEMBL11312831 | 0.75 | CYP1A2 (0.58) | PTGER1DHODHCYP1A2ADORA2AADORA2B | |
| SCHEMBL19910448 | 0.74 | PTGER1 (0.40) | PTGER1DHODHCYP1A2ADORA2AADORA2B | |
| SCHEMBL16566335 | 0.73 | TACR3 (0.51) | PTGER1CYP1A2ADORA2AADORA2BCYP2C9 | |
| SCHEMBL2682845 | 0.72 | CYP1A2 (0.55) | PTGER1DHODHCYP1A2ADORA2AADORA2B | |
| SCHEMBL4796730 | 0.72 | KDR (0.52) | CYP1A2CYP2C9CYP2C19 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| WO-2005066137-A1 | 2,5-DIARYL-1H-IMIDAZOLE-4-CARBOXAMIDES AS NEUROKININ-3 RECEPTOR MODULATORS FOR THE TREATMENT OF CENTRAL NERVOUS SYSTEM AND PERIPHERAL DISEASES | NEUROGEN CORPORATION (US) | 2005-07-21 | — | — | WO | disclosed |
| US-20050148601-A1 | Neurokinin-3 receptor modulators: diaryl imidazole derivatives | NEUROGEN CORPORATION | 2005-07-07 | — | — | US | disclosed |
Patent text — is the patent's own abstract consistent with the prediction?
For each of this compound's patents that has machine-readable text (1 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.
| Patent | Title | Text reads most about | Predicted target · text-rank |
|---|---|---|---|
| US-20050148601-A1 | Neurokinin-3 receptor modulators: diaryl imidazole derivatives | TACR1, TACR2, TACR3 | PTGER1 412/4885DHODH 3095/4885CYP1A2 1918/4885 |
“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.