SCHEMBL6255359

SCHEMBL6255359

CC(C)(C)[Si]1(c2ccccc2)C(c2ccccc2-c2nc3ccccc3s2)=C(c2ccccc2)C(c2ccccc2)=C1c1ccccc1-c1nc2ccccc2s1

nearest known ligand 0.47

Predicted protein targets (top 20)

geneUniProtsupporting neighboursconfidence
KDM4E B2RXH2 9/20 0.47
RAB9A P51151 9/20 0.47
NPC1 O15118 8/20 0.47
MAPT P10636 7/20 0.47
ALDH1A1 P00352 6/20 0.47
MEN1 O00255 5/20 0.47
KMT2A Q03164 5/20 0.47
SMN1; SMN2 Q16637 5/20 0.47
GAA P10253 3/20 0.47
TDP1 Q9NUW8 2/20 0.47
L3MBTL1 Q9Y468 1/20 0.47
P2RY6 Q15077 2/20 0.46
TNF P01375 1/20 0.44
NOD1 Q9Y239 1/20 0.44
POLB P06746 1/20 0.41
TP53 P04637 2/20 0.40
GLA P06280 2/20 0.40
HCRTR1 O43613 1/20 0.40
ILK Q13418 1/20 0.40
PKM P14618 2/20 0.39

Click a target to see other patent compounds predicted against it — the reverse direction, in place.

Similar compounds — the chemically nearest patent molecules

Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.

Compoundsimilaritytop predictedshared targets
SCHEMBL6252326 0.90 TNF (0.48) KDM4ERAB9ANPC1MAPTALDH1A1
SCHEMBL6256696 0.87 TNF (0.54) KDM4ERAB9ANPC1MAPTALDH1A1
SCHEMBL6254103 0.85 KDM4E (0.49) KDM4ERAB9ANPC1MAPTALDH1A1
SCHEMBL6256263 0.84 RAB9A (0.49) KDM4ERAB9ANPC1MAPTALDH1A1
SCHEMBL6258526 0.82 RAB9A (0.54) KDM4ERAB9ANPC1MAPTALDH1A1
SCHEMBL6253733 0.79 KDM4E (0.50) KDM4ERAB9ANPC1MAPTALDH1A1
SCHEMBL8167133 0.79 TNF (0.39) KDM4ERAB9ANPC1MAPTALDH1A1
SCHEMBL6252317 0.78 KDM4E (0.49) KDM4ERAB9ANPC1MAPTALDH1A1
SCHEMBL6259841 0.75 RAB9A (0.48) KDM4ERAB9ANPC1MAPTALDH1A1
SCHEMBL4412613 0.74 RAB9A (0.64) KDM4ERAB9ANPC1MAPTALDH1A1

Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.

Patent provenance — the patents this molecule appears in, and who filed them

Claimed or disclosed in 6 patents. claimed = in the patent's claims; disclosed = body only.

PatentTitleAssigneePublishedPriorityFilingCountryStatus
EP-1143538-B1 Organic electroluminescent element containing a silacyclopentadiene derivative CHISSO CORP (JP) 2005-09-14 EP disclosed
EP-0754691-B1 Silacyclopentadiene derivatives and an organic electroluminescent element obtained by using the silacyclopentadiene derivative CHISSO CORP (JP) 2003-11-19 EP disclosed
EP-1143538-A1 Silacyclopentadiene derivatives and an organic electroluminescent element obtained by using the silacyclopentadiene derivative Chisso Corporation (JP) 2001-10-10 EP disclosed
US-6051319-A Silacyclopentadiene derivatives and an organic electroluminescent element obtained by using the silacyclopentadiene derivative CHISSO CORPORATION (JP) 2000-04-18 US disclosed
US-5986121-A Silacyclopentadiene derivatives and an organic electroluminescent element obtained by using the silacyclopentadiene derivative CHISSO CORPORATION (JP) 1999-11-16 US disclosed
EP-0754691-A2 Silacyclopentadiene derivatives and an organic electroluminescent element obtained by using the silacyclopentadiene derivative CHISSO CORPORATION (JP) 1997-01-22 EP disclosed