SCHEMBL6255367

SCHEMBL6255367

COc1ccc(-c2nn(Cc3ccccc3)c(=O)c(C#N)c2-c2ccc(OC)cc2)cc1

nearest known ligand 0.52

Predicted protein targets (top 20)

geneUniProtsupporting neighboursconfidence
CYP2C9 P11712 2/20 0.52
CYP2C19 P33261 2/20 0.52
CYP1A2 P05177 1/20 0.52
CYP3A4 P08684 1/20 0.52
CYP2D6 P10635 1/20 0.52
HPGD P15428 3/20 0.50
ALDH1A1 P00352 3/20 0.50
ADORA1 P30542 2/20 0.50
ADORA2A P29274 2/20 0.50
KMT2A Q03164 3/20 0.49
MEN1 O00255 2/20 0.49
SMN1; SMN2 Q16637 2/20 0.49
HTT P42858 1/20 0.49
NPSR1 Q6W5P4 1/20 0.49
MAPT P10636 3/20 0.48
TDP1 Q9NUW8 2/20 0.48
NPBWR1 P48145 2/20 0.48
PDE4A P27815 1/20 0.48
PDE4B Q07343 1/20 0.48
PDE4C Q08493 1/20 0.48

Click a target to see other patent compounds predicted against it — the reverse direction, in place.

Similar compounds — the chemically nearest patent molecules

Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.

Compoundsimilaritytop predictedshared targets
SCHEMBL6258394 0.86 ADORA1 (0.46) CYP2C9CYP2C19HPGDALDH1A1ADORA1
SCHEMBL6254289 0.84 GRIA2 (0.46) CYP2C9CYP2C19HPGDALDH1A1ADORA1
SCHEMBL6260233 0.83 GRM2 (0.47) CYP2C9CYP2C19HPGDALDH1A1ADORA1
SCHEMBL6256001 0.82 GRIA2 (0.44) CYP2C9CYP2C19HPGDALDH1A1ADORA1
SCHEMBL6258294 0.82 EDNRB (0.53) CYP2C9CYP2C19CYP1A2CYP3A4CYP2D6
SCHEMBL6254280 0.81 PTGIR (0.51) HPGDALDH1A1ADORA1ADORA2AKMT2A
SCHEMBL6256500 0.80 CYP1A2 (0.53) CYP2C9CYP2C19CYP1A2CYP3A4CYP2D6
SCHEMBL6254702 0.79 PTGIR (0.47) HPGDALDH1A1KMT2ASMN1; SMN2HTT
SCHEMBL6257567 0.78 PTGIR (0.46) HPGDALDH1A1KMT2ASMN1; SMN2HTT
SCHEMBL6261363 0.78 ALDH1A1 (0.52) CYP2C9CYP2C19CYP1A2CYP3A4CYP2D6

Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.

Patent provenance — the patents this molecule appears in, and who filed them

Claimed or disclosed in 3 patents. claimed = in the patent's claims; disclosed = body only.

PatentTitleAssigneePublishedPriorityFilingCountryStatus
EP-1156039-B1 PYRIDAZIN-3-ONE DERIVATIVES AND MEDICINES CONTAINING THE SAME KOWA CO (JP) 2005-10-05 EP disclosed
US-6680316-B1 INTERLEUKIN INHIBITORS; AUTOIMMUNE, RHEUMATIC, AND GASTROINTESTINAL DISORDERS; OSTEOPOROSIS; ANTIINFLAMMATORY, ANTIISCHEMIC, AND ANTIARTHRITIC AGENTS KOWA CO., LTD. (JP) 2004-01-20 US disclosed
EP-1156039-A1 PYRIDAZIN-3-ONE DERIVATIVES AND MEDICINES CONTAINING THE SAME Kowa Co., Ltd. (JP) 2001-11-21 EP disclosed