SCHEMBL6258294

SCHEMBL6258294

COc1ccc(-c2nn(Cc3ccccc3)c(=O)c(C(=O)O)c2-c2ccc(OC)cc2)cc1

nearest known ligand 0.56

Predicted protein targets (top 20)

geneUniProtsupporting neighboursconfidence
EDNRB P24530 3/20 0.53
CYP1A2 P05177 2/20 0.52
CYP3A4 P08684 2/20 0.52
CYP2C9 P11712 2/20 0.52
CYP2C19 P33261 2/20 0.52
CYP2D6 P10635 1/20 0.52
MAPT P10636 2/20 0.48
PDE4A P27815 1/20 0.48
PDE4B Q07343 1/20 0.48
PDE4C Q08493 1/20 0.48
PDE4D Q08499 1/20 0.48
ALDH1A1 P00352 5/20 0.47
KDM4E B2RXH2 2/20 0.47
GAA P10253 1/20 0.47
PKM P14618 1/20 0.47
HPGD P15428 1/20 0.47
SMN1; SMN2 Q16637 2/20 0.47
L3MBTL1 Q9Y468 2/20 0.47
NPC1 O15118 1/20 0.47
RAB9A P51151 1/20 0.47

Click a target to see other patent compounds predicted against it — the reverse direction, in place.

Similar compounds — the chemically nearest patent molecules

Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.

Compoundsimilaritytop predictedshared targets
SCHEMBL6256500 0.91 CYP1A2 (0.53) EDNRBCYP1A2CYP3A4CYP2C9CYP2C19
SCHEMBL6256619 0.89 CYP1A2 (0.48) CYP1A2CYP3A4CYP2C9CYP2C19CYP2D6
SCHEMBL6261363 0.89 ALDH1A1 (0.52) EDNRBCYP1A2CYP3A4CYP2C9CYP2C19
SCHEMBL6259734 0.88 CYP1A2 (0.47) CYP1A2CYP3A4CYP2C9CYP2C19CYP2D6
SCHEMBL6257634 0.88 MAPT (0.59) CYP1A2CYP3A4CYP2C9CYP2C19CYP2D6
SCHEMBL6256484 0.83 KDM4E (0.43) EDNRBALDH1A1KDM4EGAAHPGD
SCHEMBL6255367 0.82 CYP2C9 (0.52) CYP1A2CYP3A4CYP2C9CYP2C19CYP2D6
SCHEMBL6258726 0.81 PTGIR (0.53) ALDH1A1KDM4EHPGDSMN1; SMN2L3MBTL1
SCHEMBL30928899 0.77 ADORA2A (0.55) CYP1A2CYP3A4CYP2C9CYP2C19CYP2D6
SCHEMBL8890615 0.77 HTT (0.51) CYP1A2CYP3A4CYP2C9CYP2C19CYP2D6

Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.

Patent provenance — the patents this molecule appears in, and who filed them

Claimed or disclosed in 3 patents. claimed = in the patent's claims; disclosed = body only.

PatentTitleAssigneePublishedPriorityFilingCountryStatus
EP-1156039-B1 PYRIDAZIN-3-ONE DERIVATIVES AND MEDICINES CONTAINING THE SAME KOWA CO (JP) 2005-10-05 EP disclosed
US-6680316-B1 INTERLEUKIN INHIBITORS; AUTOIMMUNE, RHEUMATIC, AND GASTROINTESTINAL DISORDERS; OSTEOPOROSIS; ANTIINFLAMMATORY, ANTIISCHEMIC, AND ANTIARTHRITIC AGENTS KOWA CO., LTD. (JP) 2004-01-20 US disclosed
EP-1156039-A1 PYRIDAZIN-3-ONE DERIVATIVES AND MEDICINES CONTAINING THE SAME Kowa Co., Ltd. (JP) 2001-11-21 EP disclosed