Predicted protein targets (top 9)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | EDNRA | P25101 | 20/20 | 0.71 |
| ▸ | EDNRB | P24530 | 13/20 | 0.71 |
| ▸ | ABCC3 | O15438 | 1/20 | 0.71 |
| ▸ | ABCC4 | O15439 | 1/20 | 0.71 |
| ▸ | NR1I2 | O75469 | 1/20 | 0.71 |
| ▸ | ABCB11 | O95342 | 1/20 | 0.71 |
| ▸ | DHPS | P49366 | 1/20 | 0.71 |
| ▸ | NR1H3 | Q13133 | 1/20 | 0.71 |
| ▸ | NR1I3 | Q14994 | 1/20 | 0.71 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL617288 | 0.99 | EDNRA (0.72) | EDNRAEDNRBABCC3ABCC4NR1I2 | |
| SCHEMBL29770411 | 0.99 | EDNRA (0.72) | EDNRAEDNRBABCC3ABCC4NR1I2 | |
| SCHEMBL5686011 | 0.98 | EDNRA (0.71) | EDNRAEDNRBABCC3ABCC4NR1I2 | |
| SCHEMBL13430582 | 0.93 | EDNRA (0.64) | EDNRAEDNRBABCC3ABCC4NR1I2 | |
| SCHEMBL3232307 | 0.93 | EDNRA (0.64) | EDNRAEDNRBABCC3ABCC4NR1I2 | |
| SCHEMBL1938981 | 0.92 | EDNRA (0.78) | EDNRAEDNRBABCC3ABCC4NR1I2 | |
| SCHEMBL7293756 | 0.91 | EDNRA (0.62) | EDNRAEDNRBABCC3ABCC4NR1I2 | |
| SCHEMBL7305726 | 0.90 | EDNRA (0.63) | EDNRAEDNRBABCC3ABCC4NR1I2 | |
| SCHEMBL1259727 | 0.89 | EDNRA (0.69) | EDNRAEDNRB | |
| SCHEMBL9423905 | 0.89 | EDNRA (0.70) | EDNRAEDNRBABCC3ABCC4NR1I2 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 39 patents — showing the first 20. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-2621909-B1 | PROCESS FOR PREPARING BOSENTAN MONOHYDRATE AND ITS INTERMEDIATES | ZACH SYSTEM SPA (IT) | 2018-12-19 | — | — | EP | claimed |
| US-8933226-B2 | Process for preparing Bosentan monohydrate and it's intermediates | ZACH SYSTEMS S.P.A. (IT) | 2015-01-13 | — | — | US | claimed |
| US-20130253195-A1 | PROCESS FOR PREPARING BOSENTAN MONOHYDRATE AND ITS INTERMEDIATED | ZACH SYSTEM SPA (IT) | 2013-09-26 | — | — | US | claimed |
| EP-2621909-A1 | PROCESS FOR PREPARING BOSENTAN MONOHYDRATE AND ITS INTERMEDIATES | ZaCh System S.p.A. (IT) | 2013-08-07 | — | — | EP | claimed |
| WO-2012041764-A1 | PROCESS FOR PREPARING BOSENTAN MONOHYDRATE AND ITS INTERMEDIATES | ZACH SYSTEM S.P.A. (IT) | 2012-04-05 | — | — | WO | claimed |
| EP-2240470-A2 | IMPROVED AND NOVEL PROCESS FOR THE PREPARATION OF BOSENTAN | MSN Laboratories Limited (IN) | 2010-10-20 | — | — | EP | claimed |
| WO-2009095933-A2 | IMPROVED AND NOVEL PROCESS FOR THE PREPARATION OF BOSENTAN | MSN LABORATORIES LIMITED (IN) | 2009-08-06 | — | — | WO | claimed |
| EP-1254121-A1 | PREPARATION OF SULFONAMIDES | F. HOFFMANN-LA ROCHE AG (CH) | 2002-11-06 | — | — | EP | claimed |
| WO-2001055120-A1 | PREPARATION OF SULFONAMIDES | F. HOFFMANN-LA ROCHE AG (CH) | 2001-08-02 | — | — | WO | claimed |
| US-6136971-A | Preparation of sulfonamides | ROCHE COLORADO CORPORATION (US) | 2000-10-24 | — | — | US | claimed |
| EP-2621909-B1 | PROCESS FOR PREPARING BOSENTAN MONOHYDRATE AND ITS INTERMEDIATES | ZACH SYSTEM SPA (IT) | 2018-12-19 | — | — | EP | disclosed |
| EP-2603497-B1 | A NOVEL PROCESS FOR PREPARATION OF BOSENTAN | MEGAFINE PHARMA P LTD (IN) | 2018-08-08 | — | — | EP | disclosed |
| US-9139537-B2 | Process for preparation of bosentan | MEGAFINE PHARMA(P) LTD. (IN) | 2015-09-22 | — | — | US | disclosed |
| US-8933226-B2 | Process for preparing Bosentan monohydrate and it's intermediates | ZACH SYSTEMS S.P.A. (IT) | 2015-01-13 | — | — | US | disclosed |
| US-20130296560-A1 | Novel Process For Preparation Of Bosentan | MEGAFINE PHARMA (P) LTD. (IN) | 2013-11-07 | — | — | US | disclosed |
| WO-2009047637-A1 | NOVEL POLYMORPHS OF BOSENTAN | ACTAVIS GROUP PTC EHF (IS) | 2009-04-16 | — | — | WO | disclosed |
| EP-1254121-B1 | PREPARATION OF SULFONAMIDES | HOFFMANN LA ROCHE (CH) | 2006-02-01 | — | — | EP | disclosed |
| EP-1254121-A1 | PREPARATION OF SULFONAMIDES | F. HOFFMANN-LA ROCHE AG (CH) | 2002-11-06 | — | — | EP | disclosed |
| WO-2001055120-A1 | PREPARATION OF SULFONAMIDES | F. HOFFMANN-LA ROCHE AG (CH) | 2001-08-02 | — | — | WO | disclosed |
| US-6136971-A | Preparation of sulfonamides | ROCHE COLORADO CORPORATION (US) | 2000-10-24 | — | — | US | disclosed |
Patent text — is the patent's own abstract consistent with the prediction?
For each of this compound's patents that has machine-readable text (2 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.
| Patent | Title | Text reads most about | Predicted target · text-rank |
|---|---|---|---|
| US-20130253195-A1 | PROCESS FOR PREPARING BOSENTAN MONOHYDRATE AND ITS INTERMEDIATED | NCLN, EDNRB, BTD | EDNRA 4/4885EDNRB 2/4885ABCC3 3079/4885 |
| US-20130296560-A1 | Novel Process For Preparation Of Bosentan | BMP6, EDNRB, PAH | EDNRA 9/4885EDNRB 2/4885ABCC3 4078/4885 |
“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.