Predicted protein targets (top 5)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | ABL1 | P00519 | 1/20 | 0.41 |
| ▸ | PDGFRB | P09619 | 12/20 | 0.41 |
| ▸ | KDR | P35968 | 12/20 | 0.41 |
| ▸ | AR | P10275 | 2/20 | 0.36 |
| ▸ | CHEK1 | O14757 | 1/20 | 0.36 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL8333095 | 0.81 | TP53 (0.43) | CHEK1 | |
| SCHEMBL6273613 | 0.80 | ALOX5 (0.38) | ABL1 | |
| SCHEMBL6184354 | 0.80 | AHR (0.40) | AR | |
| SCHEMBL30536418 | 0.79 | ABL1 (0.52) | ABL1CHEK1 | |
| SCHEMBL8333850 | 0.78 | ALOX5 (0.62) | ABL1PDGFRBKDR | |
| SCHEMBL6272881 | 0.76 | ABL1 (0.38) | ABL1 | |
| SCHEMBL28404933 | 0.75 | ABL1 (0.43) | ABL1 | |
| SCHEMBL2482795 | 0.74 | ALOX5 (0.59) | ABL1CHEK1 | |
| SCHEMBL8321281 | 0.74 | ALOX5 (0.65) | ABL1 | |
| SCHEMBL6274420 | 0.73 | ALOX5 (0.42) | ABL1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 3 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| WO-2005072741-A1 | ((11-OXO-10,11-DIHYDRODIBENZO [B, F] [1, 4] OXAZEPIN-1-YL)OXY) ACETIC ACID DERIVATIVES AND RELATED COMPOUNDS AS CARDIOVASCULAR PREPARATIONS USED TO TREAT ARTERIOLOSCLEROSIS | BAYER HEALTHCARE AG (DE) | 2005-08-11 | — | — | WO | disclosed |
| WO-2005072741-A1 | ((11-OXO-10,11-DIHYDRODIBENZO [B, F] [1, 4] OXAZEPIN-1-YL)OXY) ACETIC ACID DERIVATIVES AND RELATED COMPOUNDS AS CARDIOVASCULAR PREPARATIONS USED TO TREAT ARTERIOLOSCLEROSIS | BAYER HEALTHCARE AG (DE) | 2005-08-11 | — | — | WO | disclosed |
| WO-2004033437-A1 | DIBENZOXAZEPINE | BAYER HEALTHCARE AG (DE) | 2004-04-22 | — | — | WO | disclosed |