Predicted protein targets (top 13)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | CA2 | P00918 | 3/20 | 0.54 |
| ▸ | CA1 | P00915 | 2/20 | 0.54 |
| ▸ | GPR139 | Q6DWJ6 | 6/20 | 0.53 |
| ▸ | KMT2A | Q03164 | 2/20 | 0.53 |
| ▸ | SLC6A9 | P48067 | 2/20 | 0.49 |
| ▸ | SLC6A5 | Q9Y345 | 2/20 | 0.49 |
| ▸ | FOLH1 | Q04609 | 2/20 | 0.47 |
| ▸ | MMP2 | P08253 | 2/20 | 0.46 |
| ▸ | MMP9 | P14780 | 2/20 | 0.46 |
| ▸ | MEN1 | O00255 | 1/20 | 0.45 |
| ▸ | ATM | Q13315 | 1/20 | 0.45 |
| ▸ | ACE | P12821 | 2/20 | 0.45 |
| ▸ | MRGPRX4 | Q96LA9 | 1/20 | 0.45 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL27389072 | 0.89 | GPR139 (0.56) | CA2CA1GPR139SLC6A9SLC6A5 | |
| SCHEMBL5572853 | 0.89 | GPR139 (0.56) | CA2CA1GPR139SLC6A9SLC6A5 | |
| SCHEMBL5260686 | 0.86 | CA2 (0.70) | CA2CA1KMT2AFOLH1MMP2 | |
| SCHEMBL5260684 | 0.86 | CA2 (0.70) | CA2CA1KMT2AFOLH1MMP2 | |
| SCHEMBL2464334 | 0.83 | GPR139 (0.52) | GPR139SLC6A9SLC6A5FOLH1MMP2 | |
| SCHEMBL1009379 | 0.83 | GPR139 (0.52) | GPR139SLC6A9SLC6A5FOLH1MMP2 | |
| SCHEMBL6277441 | 0.83 | GPR139 (0.52) | GPR139SLC6A9SLC6A5FOLH1MMP2 | |
| SCHEMBL2750013 | 0.81 | C3AR1 (0.50) | GPR139SLC6A9SLC6A5FOLH1 | |
| SCHEMBL1694411 | 0.81 | C3AR1 (0.50) | GPR139SLC6A9SLC6A5FOLH1 | |
| SCHEMBL26907173 | 0.81 | C3AR1 (0.65) | CA2 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 4 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-0994954-B1 | T7 PROMOTER-BASED EXPRESSION SYSTEM | ASTRAZENECA AB (SE) | 2005-09-21 | — | — | EP | disclosed |
| US-6537779-B1 | Host cell transformed with a plasmid comprising operator sequences; use for cloning and expression of toxic gene products and production of heterologous proteins | ZENECA LIMITED (GB) | 2003-03-25 | — | — | US | disclosed |
| EP-0994954-A1 | T7 PROMOTER-BASED EXPRESSION SYSTEM | ZENECA LIMITED (GB) | 2000-04-26 | — | — | EP | disclosed |
| WO-1999005297-A1 | T7 PROMOTER-BASED EXPRESSION SYSTEM | ZENECA LIMITED (GB) | 1999-02-04 | — | — | WO | disclosed |