SCHEMBL6256243

SCHEMBL6256243

c1ccc(C2=C(c3nc4cc(-c5ccccc5)ccc4s3)[Si](c3ccccc3)(c3ccccc3)C(c3nc4cc(-c5ccccc5)ccc4s3)=C2c2ccccc2)cc1

nearest known ligand 0.42

Predicted protein targets (top 20)

geneUniProtsupporting neighboursconfidence
KDM4E B2RXH2 6/20 0.42
RAB9A P51151 7/20 0.40
NFKB1 P19838 7/20 0.40
NFKB2 Q00653 7/20 0.40
RELA Q04206 7/20 0.40
NPC1 O15118 6/20 0.40
HPGD P15428 3/20 0.40
STAT1 P42224 1/20 0.40
MAPT P10636 5/20 0.39
ALDH1A1 P00352 4/20 0.39
MEN1 O00255 3/20 0.39
KMT2A Q03164 3/20 0.39
GAA P10253 3/20 0.39
POLB P06746 2/20 0.39
GFER P55789 1/20 0.39
PIK3CA P42336 2/20 0.38
PI4KA P42356 1/20 0.38
PI4KB Q9UBF8 1/20 0.38
SMN1; SMN2 Q16637 6/20 0.38
PKM P14618 3/20 0.38

Click a target to see other patent compounds predicted against it — the reverse direction, in place.

Similar compounds — the chemically nearest patent molecules

Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.

Compoundsimilaritytop predictedshared targets
SCHEMBL6254362 0.87 SMN1; SMN2 (0.49) KDM4ERAB9ANFKB1NFKB2RELA
SCHEMBL6259841 0.86 RAB9A (0.48) KDM4ERAB9ANFKB1NFKB2RELA
SCHEMBL6253068 0.85 KDM4E (0.43) KDM4ERAB9ANFKB1NFKB2RELA
SCHEMBL8167133 0.84 TNF (0.39) KDM4ERAB9ANFKB1NFKB2RELA
SCHEMBL6256118 0.82 KDM4E (0.43) KDM4ERAB9ANFKB1NFKB2RELA
SCHEMBL6256338 0.81 KDM4E (0.42) KDM4ERAB9ANFKB1NFKB2RELA
SCHEMBL6252138 0.80 RAB9A (0.54) KDM4ERAB9ANFKB1NFKB2RELA
SCHEMBL6253424 0.77 RAB9A (0.55) KDM4ERAB9ANFKB1NFKB2RELA
SCHEMBL6254376 0.76 SMN1; SMN2 (0.43) KDM4ERAB9ANFKB1NFKB2RELA
SCHEMBL6256263 0.76 RAB9A (0.49) KDM4ERAB9ANFKB1NFKB2RELA

Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.

Patent provenance — the patents this molecule appears in, and who filed them

Claimed or disclosed in 6 patents. claimed = in the patent's claims; disclosed = body only.

PatentTitleAssigneePublishedPriorityFilingCountryStatus
EP-1143538-B1 Organic electroluminescent element containing a silacyclopentadiene derivative CHISSO CORP (JP) 2005-09-14 EP disclosed
EP-0754691-B1 Silacyclopentadiene derivatives and an organic electroluminescent element obtained by using the silacyclopentadiene derivative CHISSO CORP (JP) 2003-11-19 EP disclosed
EP-1143538-A1 Silacyclopentadiene derivatives and an organic electroluminescent element obtained by using the silacyclopentadiene derivative Chisso Corporation (JP) 2001-10-10 EP disclosed
US-6051319-A Silacyclopentadiene derivatives and an organic electroluminescent element obtained by using the silacyclopentadiene derivative CHISSO CORPORATION (JP) 2000-04-18 US disclosed
US-5986121-A Silacyclopentadiene derivatives and an organic electroluminescent element obtained by using the silacyclopentadiene derivative CHISSO CORPORATION (JP) 1999-11-16 US disclosed
EP-0754691-A2 Silacyclopentadiene derivatives and an organic electroluminescent element obtained by using the silacyclopentadiene derivative CHISSO CORPORATION (JP) 1997-01-22 EP disclosed