Predicted protein targets (top 15)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | GRM2 | Q14416 | 2/20 | 0.42 |
| ▸ | GRIN2B | Q13224 | 7/20 | 0.39 |
| ▸ | GRIN1 | Q05586 | 6/20 | 0.39 |
| ▸ | ATM | Q13315 | 2/20 | 0.39 |
| ▸ | ATR | Q13535 | 1/20 | 0.39 |
| ▸ | P2RX3 | P56373 | 1/20 | 0.38 |
| ▸ | FTO | Q9C0B1 | 1/20 | 0.38 |
| ▸ | GAA | P10253 | 1/20 | 0.38 |
| ▸ | KDM4E | B2RXH2 | 1/20 | 0.37 |
| ▸ | ALDH1A1 | P00352 | 1/20 | 0.37 |
| ▸ | MAPT | P10636 | 1/20 | 0.37 |
| ▸ | L3MBTL1 | Q9Y468 | 1/20 | 0.37 |
| ▸ | MAPK14 | Q16539 | 1/20 | 0.36 |
| ▸ | PIK3CA | P42336 | 2/20 | 0.36 |
| ▸ | MTOR | P42345 | 2/20 | 0.36 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL10146334 | 0.82 | GRM2 (0.64) | GRM2P2RX3FTOPIK3CAMTOR | |
| SCHEMBL625686 | 0.71 | GRM2 (0.51) | GRM2GAAKDM4EALDH1A1MAPT | |
| SCHEMBL12505191 | 0.71 | GRM2 (0.44) | GRM2P2RX3 | |
| SCHEMBL14991857 | 0.68 | GRM2 (0.55) | GRM2ATMP2RX3 | |
| SCHEMBL10146330 | 0.68 | GRM2 (0.54) | GRM2 | |
| SCHEMBL25864985 | 0.67 | GRM2 (0.57) | GRM2GAAKDM4EALDH1A1MAPT | |
| SCHEMBL627293 | 0.66 | GRM2 (0.46) | GRM2GRIN2BGRIN1ALDH1A1MAPT | |
| SCHEMBL10146325 | 0.66 | GRM2 (0.64) | GRM2 | |
| SCHEMBL624936 | 0.64 | GRM2 (0.66) | GRM2PIK3CAMTOR | |
| SCHEMBL10146333 | 0.64 | GRM2 (0.70) | GRM2GRIN2BGRIN1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-2603079-A1 | POSITIVE ALLOSTERIC MODULATORS OF MGLUR2 | Merck Sharp & Dohme Corp. (US) | 2013-06-19 | — | — | EP | claimed |
| WO-2012021382-A1 | POSITIVE ALLOSTERIC MODULATORS OF MGLUR2 | MERCK SHARP & DOHME CORP. (US) | 2012-02-16 | — | — | WO | claimed |