SCHEMBL6257151

SCHEMBL6257151

CC(C)c1cccc2c1C(=O)N(C(CC(=O)O)C(N)=O)C2=O

nearest known ligand 0.48

Predicted protein targets (top 20)

geneUniProtsupporting neighboursconfidence
ALDH1A1 P00352 3/20 0.48
POLB P06746 3/20 0.48
L3MBTL1 Q9Y468 1/20 0.48
ANPEP P15144 1/20 0.40
DPP4 P27487 1/20 0.40
KDM4E B2RXH2 1/20 0.40
TP53 P04637 1/20 0.40
GLA P06280 1/20 0.40
CYP3A4 P08684 1/20 0.40
CYP2D6 P10635 1/20 0.40
HPGD P15428 1/20 0.40
ALOX12 P18054 1/20 0.40
NFKB1 P19838 1/20 0.40
APEX1 P27695 1/20 0.40
MAPK1 P28482 1/20 0.40
HSD17B10 Q99714 1/20 0.40
LMNA P02545 2/20 0.40
HTT P42858 1/20 0.40
GAA P10253 1/20 0.38
TNF P01375 3/20 0.38

Click a target to see other patent compounds predicted against it — the reverse direction, in place.

Similar compounds — the chemically nearest patent molecules

Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.

Compoundsimilaritytop predictedshared targets
SCHEMBL6259492 0.90 POLB (0.48) ALDH1A1POLBANPEPDPP4KDM4E
SCHEMBL6261469 0.88 ALDH1A1 (0.53) ALDH1A1POLBL3MBTL1ANPEPDPP4
SCHEMBL6257605 0.86 ALDH1A1 (0.51) ALDH1A1POLBL3MBTL1KDM4ETP53
SCHEMBL6257615 0.85 ALDH1A1 (0.44) ALDH1A1POLBL3MBTL1ANPEPDPP4
SCHEMBL6259763 0.84 ALDH1A1 (0.52) ALDH1A1POLBL3MBTL1DPP4KDM4E
SCHEMBL6261421 0.84 POLB (0.49) ALDH1A1POLBL3MBTL1ANPEPDPP4
SCHEMBL24326937 0.82 ALDH1A1 (0.42) ALDH1A1POLBL3MBTL1ANPEPDPP4
SCHEMBL6256204 0.81 ALDH1A1 (0.47) ALDH1A1POLBL3MBTL1KDM4ETP53
SCHEMBL6694333 0.81 ALDH1A1 (0.69) ALDH1A1POLBL3MBTL1KDM4ETP53
SCHEMBL6257128 0.81 KMT2A (0.56) ALDH1A1POLBL3MBTL1ANPEPDPP4

Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.

Patent provenance — the patents this molecule appears in, and who filed them

Claimed or disclosed in 4 patents. claimed = in the patent's claims; disclosed = body only.

PatentTitleAssigneePublishedPriorityFilingCountryStatus
EP-1163219-B1 SUBSTITUTED 1-OXO- AND 1,3-DIOXOISOINDOLINES AND THEIR USE IN PHARMACEUTICAL COMPOSITIONS FOR REDUCING INFLAMMATORY CYTOKINE LEVELS CELGENE CORP (US) 2005-10-12 EP disclosed
US-6380239-B1 FOR THERAPY OF ARTHRITIS, RHEUMATOID ARTHRITIS, OSTEOARTHRITIS, REPERFUSION INJURY, INFLAMMATORY BOWEL DISEASE, CROHN'S DISEASE, ULCERATIVE COLITIS, SYSTEMIC LUPUS ERYTHREMATOSIS, SCLERODERMA, APHTHOUS ULCERS, ASTHMA CELGENE CORPORATION 2002-04-30 US disclosed
EP-1163219-A1 SUBSTITUTED 1-OXO- AND 1,3-DIOXOISOINDOLINES AND THEIR USE IN PHARMACEUTICAL COMPOSITIONS FOR REDUCING INFLAMMATORY CYTOKINE LEVELS CELGENE CORPORATION (US) 2001-12-19 EP disclosed
WO-2000055134-A1 SUBSTITUTED 1-OXO- AND 1,3-DIOXOISOINDOLINES AND THEIR USE IN PHARMACEUTICAL COMPOSITIONS FOR REDUCING INFLAMMATORY CYTOKINE LEVELS CELGENE CORPORATION (US) 2000-09-21 WO disclosed