⚠ Novel chemotype — no close known analogue (best Tanimoto < 0.3). Unexplored chemical space relative to ChEMBL.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL20715 | 0.72 | — | — | |
| SCHEMBL2958765 | 0.72 | — | — | |
| SCHEMBL24665 | 0.72 | — | — | |
| SCHEMBL16741 | 0.72 | — | — | |
| SCHEMBL3667891 | 0.72 | — | — | |
| SCHEMBL31376856 | 0.72 | — | — | |
| SCHEMBL3823311 | 0.72 | — | — | |
| SCHEMBL8626057 | 0.72 | — | — | |
| Hydroxyamine SCHEMBL272868 | 0.67 | — | — | |
| Hydrochloric Acid SCHEMBL3442206 | 0.67 | — | — |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 262 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-12195489-B2 | Spiro-bisphosphorous compound, and preparation and application thereof | GUANGDONG OXO CHEM LTD. (CN) | 2025-01-14 | — | — | US | claimed |
| US-20240309372-A1 | STABILIZATION OF OLIGONUCLEOTIDE AND OLIGONUCLEOTIDE-PROTEIN COMPLEX USING ALKYLATED PHOSPHATE | UNIV MASSACHUSETTS (US) | 2024-09-19 | — | — | US | claimed |
| WO-2023023513-A9 | STABILIZATION OF OLIGONUCLEOTIDE AND OLIGONUCLEOTIDE-PROTEIN COMPLEX USING ALKYLATED PHOSPHATE | UNIVERSITY OF MASSACHUSETTS (US) | 2023-06-01 | — | — | WO | claimed |
| WO-2023023513-A1 | STABILIZATION OF OLIGONUCLEOTIDE AND OLIGONUCLEOTIDE-PROTEIN COMPLEX USING ALKYLATED PHOSPHATE | UNIVERSITY OF MASSACHUSETTS (US) | 2023-02-23 | — | — | WO | claimed |
| CN-114957364-A | Iodoglycoside base, preparation method thereof and constructed amphiphilic nucleic acid | 湖南大学 | 2022-08-30 | — | — | CN | claimed |
| US-20220242891-A1 | SPIRO-BISPHOSPHOROUS COMPOUND, AND PREPARATION AND APPLICATION THEREOF | GUANGDONG OXO CHEM LTD. (CN) | 2022-08-04 | — | — | US | claimed |
| EP-2744814-A1 | AMIDO-FLUOROPHOSPHITE COMPOUNDS AND CATALYSTS | Eastman Chemical Company (US) | 2014-06-25 | — | — | EP | claimed |
| EP-1888748-B1 | STABLE AND SELECTIVE FORMATION OF HOOGSTEEN-TYPE TRIPLEXES AND DUPLEXES USING TWISTED INTERCALATING NUCLEIC ACIDS (TINA) AND PROCESS FOR THE PREPARATION OF TINA | TINA HOLDING APS (DK) | 2013-08-28 | — | — | EP | claimed |
| US-8492593-B2 | Amido-fluorophosphite compounds and catalysts | EASTMAN CHEMICAL COMPANY (US) | 2013-07-23 | — | — | US | claimed |
| WO-2013025363-A1 | AMIDO-FLUOROPHOSPHITE COMPOUNDS AND CATALYSTS | EASTMAN CHEMICAL COMPANY (US) | 2013-02-21 | — | — | WO | claimed |
| US-20130046112-A1 | AMIDO-FLUOROPHOSPHITE COMPOUNDS AND CATALYSTS | EASTMAN CHEMICAL COMPANY (US) | 2013-02-21 | — | — | US | claimed |
| US-20090216003-A1 | STABLE AND SELECTIVE FORMATION OF HOOGSTEEN-TYPE TRIPLEXES AND DUPLEXES USING TWISTED INTERCALATING NUCLEIC ACIDS (TINA) AND PROCESS FOR THE PREPARATION OF TINA | TINA HOLDING APS (DK) | 2009-08-27 | — | — | US | claimed |
| EP-1888748-A2 | STABLE AND SELECTIVE FORMATION OF HOOGSTEEN-TYPE TRIPLEXES AND DUPLEXES USING TWISTED INTERCALATING NUCLEIC ACIDS (TINA) AND PROCESS FOR THE PREPARATION OF TINA | Tina Holding ApS (DK) | 2008-02-20 | — | — | EP | claimed |
| WO-2006125447-A2 | STABLE AND SELECTIVE FORMATION OF HOOGSTEEN-TYPE TRIPLEXES AND DUPLEXES USING TWISTED INTERCALATING NUCLEIC ACIDS (TINA) AND PROCESS FOR THE PREPARATION OF TINA | TINA HOLDING APS (DK) | 2006-11-30 | — | — | WO | claimed |
| WO-2003087188-A1 | OLIGONUCLEOTIDE-MODIFIED ROMP POLYMERS AND CO-POLYMERS | NANOSPHERE, INC. (US) | 2003-10-23 | — | — | WO | claimed |
| US-20030113740-A1 | Oligonucleotide-modified ROMP polymers and co-polymers | NORTHWESTERN UNIVERSITY | 2003-06-19 | — | — | US | claimed |
| US-5750674-A | Methods and compounds for the stereoselective enrichment of oligonucleotide diastereomers and oligonucleotides thereby produced | HYBRIDON, INC. (US) | 1998-05-12 | — | — | US | claimed |
| WO-1996039413-A1 | METHODS AND COMPOUNDS FOR THE SYNTHESIS OF OLIGONUCLEOTIDES AND THE OLIGONUCLEOTIDES THEREBY PRODUCED | HYBRIDON, INC. (US) | 1996-12-12 | — | — | WO | claimed |
| WO-1995026359-A1 | MACROMOLECULAR STRUCTURES FOR BORON NEUTRON-CAPTURE THERAPY | REGENTS OF THE UNIVERSITY OF CALIFORNIA (US) | 1995-10-05 | — | — | WO | claimed |
| JP-3188088-A | — | — | None | — | — | JP | disclosed |
| JP-5213986-A | — | — | None | — | — | JP | disclosed |
| EP-4547843-A2 | INHIBITORY NUCLEIC ACIDS FOR ITFG1 | Lerna Biopharma Pte. Ltd. (SG) | 2025-05-07 | — | — | EP | disclosed |
| US-12195489-B2 | Spiro-bisphosphorous compound, and preparation and application thereof | GUANGDONG OXO CHEM LTD. (CN) | 2025-01-14 | — | — | US | disclosed |
| US-20240327842-A1 | GALNAC-MONOMERS AND GALNAC-NUCLEIC ACID CONJUGATES | LERNA BIOPHARMA PTE. LTD. (SG) | 2024-10-03 | — | — | US | disclosed |
| EP-3204397-B1 | GALNAC PHOSPHORAMIDITES, NUCLEIC ACID CONJUGATES THEREOF AND THEIR USE | HOFFMANN LA ROCHE (CH) | 2024-10-02 | — | — | EP | disclosed |
| US-20240309372-A1 | STABILIZATION OF OLIGONUCLEOTIDE AND OLIGONUCLEOTIDE-PROTEIN COMPLEX USING ALKYLATED PHOSPHATE | UNIV MASSACHUSETTS (US) | 2024-09-19 | — | — | US | disclosed |
| EP-4384528-A2 | GALNAC-MONOMERS AND GALNAC-NUCLEIC ACID CONJUGATES | Lerna Biopharma Pte. Ltd. (SG) | 2024-06-19 | — | — | EP | disclosed |
| CN-117924364-A | Chiral agent for preparing homogeneous oligomer | 卫材 R&D 管理有限公司 | 2024-04-26 | — | — | CN | disclosed |
| US-20240066047-A1 | ANTIBODY-DRUG CONJUGATES COMPRISING A CYCLIC DINUCLEOTIDE | TAKEDA PHARMACEUTICAL COMPANY LIMITED (JP) | 2024-02-29 | — | — | US | disclosed |
| CN-113527066-B | Chiral spiro compound and preparation method and application thereof | 香港科技大学深圳研究院 | 2024-02-20 | — | — | CN | disclosed |
| CN-108350005-B | Chiral agent for preparing homogeneous oligomer | 卫材R&D管理有限公司 | 2024-02-06 | — | — | CN | disclosed |
| WO-2024003148-A2 | INHIBITORY NUCLEIC ACIDS FOR ITFG1 | LERNA BIOPHARMA PTE. LTD. (SG) | 2024-01-04 | — | — | WO | disclosed |
| WO-2023200934-A1 | PREPARATION OF ORGANOSILICON COMPOUNDS WITH ALDEHYDE FUNCTIONALITY | DOW GLOBAL TECHNOLOGIES LLC (US) | 2023-10-19 | — | — | WO | disclosed |
| WO-2023200935-A1 | INDOLE-FUNCTIONALIZED BISPHOSPHORAMIDITES, METHODS FOR THE PREPARATION THEREOF, AND RHODIUM-LIGAND COMPLEX | DOW GLOBAL TECHNOLOGIES LLC (US) | 2023-10-19 | — | — | WO | disclosed |
| CN-116726996-A | Catalyst for isomerization of branched unsaturated fatty nitrile, preparation method and application thereof | 北京旭阳科技有限公司 | 2023-09-12 | — | — | CN | disclosed |
| EP-4225322-A1 | N-ACETYLGALACTOSAMINE(GALNAC)-DERIVED COMPOUNDS AND OLIGONUCLEOTIDES | Adarx Pharmaceuticals, Inc. (US) | 2023-08-16 | — | — | EP | disclosed |
| WO-2023149038-A1 | PHENOXAZINE DERIVATIVE AND DRUG DELIVERY SYSTEM FORMULATION USING SAME | 国立大学法人大阪大学 | 2023-08-10 | — | — | WO | disclosed |
| US-11666594-B2 | Antibody-drug conjugates comprising a cyclic dinucleotide | TAKEDA PHARMACEUTICAL COMPANY LIMITED (JP) | 2023-06-06 | — | — | US | disclosed |
| WO-2023023513-A9 | STABILIZATION OF OLIGONUCLEOTIDE AND OLIGONUCLEOTIDE-PROTEIN COMPLEX USING ALKYLATED PHOSPHATE | UNIVERSITY OF MASSACHUSETTS (US) | 2023-06-01 | — | — | WO | disclosed |
| WO-2023023513-A1 | STABILIZATION OF OLIGONUCLEOTIDE AND OLIGONUCLEOTIDE-PROTEIN COMPLEX USING ALKYLATED PHOSPHATE | UNIVERSITY OF MASSACHUSETTS (US) | 2023-02-23 | — | — | WO | disclosed |
| WO-2023017004-A1 | INHIBITORY NUCLEIC ACIDS FOR PCSK9 | Cargene Therapeutics Pte. Ltd. (SG) | 2023-02-16 | — | — | WO | disclosed |
| WO-2023016999-A2 | Compounds | Cargene Therapeutics Pte. Ltd. (SG) | 2023-02-16 | — | — | WO | disclosed |
| EP-4126070-A2 | SYNTHESIS OF MODIFIED OLIGONUCLEOTIDES WITH INCREASED STABILITY | University Of Massachusetts (US) | 2023-02-08 | — | — | EP | disclosed |
| US-11505569-B2 | GalNAc phosphoramidites, nucleic acid conjugates thereof and their use | HOFFMANN-LA ROCHE INC. (US) | 2022-11-22 | — | — | US | disclosed |
| CN-114957364-A | Iodoglycoside base, preparation method thereof and constructed amphiphilic nucleic acid | 湖南大学 | 2022-08-30 | — | — | CN | disclosed |
| US-20220242891-A1 | SPIRO-BISPHOSPHOROUS COMPOUND, AND PREPARATION AND APPLICATION THEREOF | GUANGDONG OXO CHEM LTD. (CN) | 2022-08-04 | — | — | US | disclosed |
| WO-2022124410-A1 | CYTOSINE-TYPE CROSSLINKED NUCLEOSIDE AMIDITE CRYSTALS AND METHOD FOR PRODUCING SAME | ヤマサ醤油株式会社 | 2022-06-16 | — | — | WO | disclosed |
| WO-2021195533-A2 | SYNTHESIS OF MODIFIED OLIGONUCLEOTIDES WITH INCREASED STABILITY | UNIVERSITY OF MASSACHUSETTS (US) | 2021-09-30 | — | — | WO | disclosed |
| WO-2021162070-A1 | METHOD FOR PRODUCING MONOMER FOR NUCLEIC ACID PRODUCTION | 東レ株式会社 | 2021-08-19 | — | — | WO | disclosed |
| US-20210137962-A9 | CYCLIC DINUCLEOTIDE | TAKEDA PHARMACEUTICAL COMPANY LIMITED (JP) | 2021-05-13 | — | — | US | disclosed |
| US-10980825-B2 | Cyclic dinucleotide | TAKEDA PHARMACEUTICAL COMPANY LIMITED (JP) | 2021-04-20 | — | — | US | disclosed |
| US-20210106607-A1 | ANTIBODY-DRUG CONJUGATES COMPRISING A CYCLIC DINUCLEOTIDE | TAKEDA PHARMACEUTICAL COMPANY LIMITED (JP) | 2021-04-15 | — | — | US | disclosed |
| EP-3512861-B1 | CYCLIC DINUCLEOTIDES AS STING (STIMULATOR OF INTERFERON GENES) AGONISTS | TAKEDA PHARMACEUTICALS CO (JP) | 2021-02-17 | — | — | EP | disclosed |
| US-20210017214-A1 | GALNAC PHOSPHORAMIDITES, NUCLEIC ACID CONJUGATES THEREOF AND THEIR USE | HOFFMANN LA ROCHE (US) | 2021-01-21 | — | — | US | disclosed |
| EP-3512861-A2 | CYCLIC DINUCLEOTIDES AS STING (STIMULATOR OF INTEFERON GENES) AGONISTS | Takeda Pharmaceutical Company Limited (JP) | 2019-07-24 | — | — | EP | disclosed |
| US-20190192549-A1 | CYCLIC DINUCLEOTIDE | TAKEDA PHARMACEUTICALS CO (JP) | 2019-06-27 | — | — | US | disclosed |
| US-10131908-B2 | 5′ phosphate mimics | ALNYLAM PHARMACEUTICALS, INC. (US) | 2018-11-20 | — | — | US | disclosed |
| EP-2794622-B1 | PROTECTED LINKER COMPOUNDS | RESEACHEM GMBH (CH) | 2018-08-08 | — | — | EP | disclosed |
| US-10022454-B2 | Functionalized phosphorodiamites for therapeutic oligonucleotide synthesis | LIPOSCIENCES, LLC (US) | 2018-07-17 | — | — | US | disclosed |
| WO-2018100558-A2 | CYCLIC DINUCLEOTIDE | TAKEDA PHARMACEUTICAL COMPANY LIMITED (JP) | 2018-06-07 | — | — | WO | disclosed |
| US-20170327524-A1 | GALNAC PHOSPHORAMIDITES, NUCLEIC ACID CONJUGATES THEREOF AND THEIR USE | HOFFMANN-LA ROCHE INC. | 2017-11-16 | — | — | US | disclosed |
| EP-3204397-A1 | GALNAC PHOSPHORAMIDITES, NUCLEIC ACID CONJUGATES THEREOF AND THEIR USE | F. Hoffmann-La Roche AG (CH) | 2017-08-16 | — | — | EP | disclosed |
| US-20170224832-A9 | SELF DELIVERING BIO-LABILE PHOSPHATE PROTECTED PRO-OLIGOS FOR OLIGONUCLEOTIDE BASED THERAPEUTICS AND MEDIATING RNA INTERFERENCE | PETERSEN SCOTT G (US) | 2017-08-10 | — | — | US | disclosed |
| US-9725479-B2 | 5′-end derivatives | IONIS PHARMACEUTICALS, INC. (US) | 2017-08-08 | — | — | US | disclosed |
| EP-2899197-B1 | OLIGONUCLEOTIDE AND ARTIFICIAL NUCLEOSIDE HAVING GUANIDINE BRIDGE | UNIV OSAKA (JP) | 2017-03-22 | — | — | EP | disclosed |
| EP-3137478-A2 | PHOSPHOROUS PROTECTING GROUPS AND METHODS OF PREPARATION AND USE THEREOF | Agilent Technologies, Inc. (US) | 2017-03-08 | — | — | EP | disclosed |
| CN-101506368-B | Transduction of transport nucleic acids by reversible phosphotriester charge neutralization protecting groups | 加利福尼亚大学董事会 | 2017-02-08 | — | — | CN | disclosed |
| US-9534003-B2 | Protected linker compounds | RESEACHEM GMBH (CH) | 2017-01-03 | — | — | US | disclosed |
| EP-3067359-A1 | SELF DELIVERING BIO-LABILE PHOSPHATE PROTECTED PRO-OLIGOS FOR OLIGONUCLEOTIDE BASED THERAPEUTICS AND MEDIATING RNA INTERFERENCE | Petersen, Scott G. (US) | 2016-09-14 | — | — | EP | disclosed |
| WO-2016055601-A1 | GALNAC PHOSPHORAMIDITES, NUCLEIC ACID CONJUGATES THEREOF AND THEIR USE | F. HOFFMANN-LA ROCHE AG (CH) | 2016-04-14 | — | — | WO | disclosed |
| EP-2346883-B1 | SELF DELIVERING BIO-LABILE PHOSPHATE PROTECTED PRO-OLIGOS FOR OLIGONUCLEOTIDE BASED THERAPEUTICS AND MEDIATING RNA INTERFERENCE | PETERSEN SCOTT G (US) | 2016-03-23 | — | — | EP | disclosed |
| US-RE45907-E1 | Functionalized stilbene derivatives as improved vascular targeting agents | OXIGENE, INC. (US) | 2016-03-01 | — | — | US | disclosed |
| US-9221863-B2 | Transiently bonding drag-tags for separation modalities | CARNEGIE MELLON UNIVERSITY (US) | 2015-12-29 | — | — | US | disclosed |
| WO-2015168461-A2 | PHOSPHOROUS PROTECTING GROUPS AND METHODS OF PREPARATION AND USE THEREOF | AGILENT TECHNOLOGIES, INC. (US) | 2015-11-05 | — | — | WO | disclosed |
| US-RE45720-E1 | Functionalized stilbene derivatives as improved vascular targeting agents | OXIGENE, INC. (US) | 2015-10-06 | — | — | US | disclosed |
| US-9121065-B2 | Nanoparticle-oligonucleotide hybrid structures and methods of use thereof | THE TRUSTEES OF THE UNIVERSITY OF PENNSYLVANIA (US) | 2015-09-01 | — | — | US | disclosed |
| US-9102937-B2 | Stable and selective formation of hoogsteen-type triplexes and duplexes using twisted intercalating nucleic acids (TINA) and process for the preparation of TINA | TINA HOLDING APS (DK) | 2015-08-11 | — | — | US | disclosed |
| EP-2899197-A1 | OLGIONUCLEOTIDE AND ARTIFICIAL NUCLEOSIDE HAVING GUANIDINE BRIDGE | Osaka University (JP) | 2015-07-29 | — | — | EP | disclosed |
| CN-101238213-B | Stable and selective formation of hoogsteen-type triplexes and duplexes using twisted intercalating nucleic acids (TINA) and process for the preparation of tina | TINA HOLDING APS | 2015-05-20 | — | — | CN | disclosed |
| US-20150080457-A1 | 5' PHOSPHATE MIMICS | BANK OF AMERICA, N.A. | 2015-03-19 | — | — | US | disclosed |
| CN-103237780-B | Nucleoside analog or salt thereof, oligonucleotide analog, gene expression inhibitor, and nucleic acid probe for detecting gene | JAPAN SCIENCE & TECH AGENCY | 2015-03-04 | — | — | CN | disclosed |
| US-20150038368-A1 | Biomolecule Immobilization On A Surface via Hydrophobic Interactions | APPLIED BIOSYSTEMS LLC (US) | 2015-02-05 | — | — | US | disclosed |
| US-20150011746-A1 | Protected Linker Compounds | RESEACHEM GMBH (CH) | 2015-01-08 | — | — | US | disclosed |
| US-8927513-B2 | 5′ phosphate mimics | ALNYLAM PHARMACEUTICALS, INC. (US) | 2015-01-06 | — | — | US | disclosed |
| US-20140329775-A1 | SELF DELIVERING BIO-LABILE PHOSPHATE PROTECTED PRO-OLIGOS FOR OLIGONUCLEOTIDE BASED THERAPEUTICS AND MEDIATING RNA INTERFERENCE | PETERSEN SCOTT G (US) | 2014-11-06 | — | — | US | disclosed |
| EP-2794622-A1 | PROTECTED LINKER COMPOUNDS | Reseachem GmbH (CH) | 2014-10-29 | — | — | EP | disclosed |
| EP-2744814-A1 | AMIDO-FLUOROPHOSPHITE COMPOUNDS AND CATALYSTS | Eastman Chemical Company (US) | 2014-06-25 | — | — | EP | disclosed |
| US-8664195-B2 | Phosphorus-containing prodrugs | METABASIS THERAPEUTICS, INC. (US) | 2014-03-04 | — | — | US | disclosed |
| US-20130323836-A1 | 5'-END DERIVATIVES | ISIS PHARMACEUTICALS, INC. (US) | 2013-12-05 | — | — | US | disclosed |
| US-8569516-B2 | Compounds and methods for fluorescent labeling | ELITECH HOLDING B.V. (NL) | 2013-10-29 | — | — | US | disclosed |
| WO-2013126034-A1 | SYNTHESIS OF HIGH PURITY DMT-C3-DISULFIDE PHOSPHORAMIDITE | CHEMGENES CORPORATION (US) | 2013-08-29 | — | — | WO | disclosed |
| EP-1888748-B1 | STABLE AND SELECTIVE FORMATION OF HOOGSTEEN-TYPE TRIPLEXES AND DUPLEXES USING TWISTED INTERCALATING NUCLEIC ACIDS (TINA) AND PROCESS FOR THE PREPARATION OF TINA | TINA HOLDING APS (DK) | 2013-08-28 | — | — | EP | disclosed |
| US-8501441-B2 | Target amplification and sequencing with primers comprising triplex forming monomer units | QUANTIBACT A/S (DK) | 2013-08-06 | — | — | US | disclosed |
| US-8492593-B2 | Amido-fluorophosphite compounds and catalysts | EASTMAN CHEMICAL COMPANY (US) | 2013-07-23 | — | — | US | disclosed |
| US-20130171646-A1 | NANOP ARTICLE-OLIGONUCLEOTIDE HYBRID STRUCTURES AND METHODS OF USE THEREOF | THE TRUSTEES OF THE UNIVERSITY OF PENNSYLVANIA | 2013-07-04 | — | — | US | disclosed |
| EP-2265729-B1 | TARGET AMPLIFICATION AND SEQUENCING WITH PRIMERS COMPRISING TRIPLEX FORMING MONOMER UNITS | QUANTIBACT AS (DK) | 2013-07-03 | — | — | EP | disclosed |
| WO-2013091120-A1 | PROTECTED LINKER COMPOUNDS | RESEACHEM GMBH (CH) | 2013-06-27 | — | — | WO | disclosed |
| WO-2013025363-A1 | AMIDO-FLUOROPHOSPHITE COMPOUNDS AND CATALYSTS | EASTMAN CHEMICAL COMPANY (US) | 2013-02-21 | — | — | WO | disclosed |
| US-20130046112-A1 | AMIDO-FLUOROPHOSPHITE COMPOUNDS AND CATALYSTS | EASTMAN CHEMICAL COMPANY (US) | 2013-02-21 | — | — | US | disclosed |
| EP-1060182-B1 | NOVEL PRODRUGS FOR PHOSPHORUS-CONTAINING COMPOUNDS | METABASIS THERAPEUTICS INC (US) | 2012-12-19 | — | — | EP | disclosed |
| EP-2097427-B1 | COMPOUNDS AND METHODS FOR SYNTHESIS AND PURIFICATION OF OLIGONUCLEOTIDES | ROCHE DIAGNOSTICS GMBH (DE) | 2012-11-21 | — | — | EP | disclosed |
| US-20120157511-A1 | 5' PHOSPHATE MIMICS | ALNYLAM PHARMACEUTICALS, INC. (US) | 2012-06-21 | — | — | US | disclosed |
| US-20120093729-A1 | NOVEL PHOSPHORUS-CONTAINING PRODRUGS | METABASIS THERAPEUTICS, INC. (US) | 2012-04-19 | — | — | US | disclosed |
| WO-2012021516-A2 | NANOPARTICLE-OLIGONUCLETIDE HYBRID STRUCTURES AND METHODS OF USE THEREOF | THE TRUSTEES OF THE UNIVERSITY OF PENNSYLVANIA (US) | 2012-02-16 | — | — | WO | disclosed |
| US-8080536-B2 | Phosphorus-containing prodrugs | METABASIS THERAPEUTICS, INC. (US) | 2011-12-20 | — | — | US | disclosed |
| US-8071737-B2 | Nucleic acid ligand complexes | Glead Sciences, Inc. (US) | 2011-12-06 | — | — | US | disclosed |
| US-20110294869-A1 | SELF DELIVERING BIO-LABILE PHOSPHATE PROTECTED PRO-OLIGOS FOR OLIGONUCLEOTIDE BASED THERAPEUTICS AND MEDIATING RNA INTERFERENCE | TRAVERSA THERAPEUTICS, INC. (US) | 2011-12-01 | — | — | US | disclosed |
| US-20110212030-A1 | Nucleic Acid Ligand Complexes | GILEAD SCIENCES, INC. (US) | 2011-09-01 | — | — | US | disclosed |
| EP-2346883-A2 | SELF DELIVERING BIO-LABILE PHOSPHATE PROTECTED PRO-OLIGOS FOR OLIGONUCLEOTIDE BASED THERAPEUTICS AND MEDIATING RNA INTERFERENCE | Traversa Therapeutics, Inc. (US) | 2011-07-27 | — | — | EP | disclosed |
| WO-2011038259-A1 | SYNTHETIC GLYCOSYL HYDROLASE BASED ON DNA NANOWEAVES | INCITOR INCORPORATED (US) | 2011-03-31 | — | — | WO | disclosed |
| US-20110076728-A1 | TARGET AMPLIFICATION AND SEQUENCING WITH PRIMERS COMPRISING TRIPLEX FORMING MONOMER UNITS | QUANTIBACT A/S | 2011-03-31 | — | — | US | disclosed |
| WO-2011005821-A1 | REDUCTIVE RELEASE PROBES CONTAINING A CHEMOSELECTIVELY CLEAVABLE ALPHA-AZIDOETHER LINKER AND METHODS OF USE THEREOF | THE BOARD OF TRUSTEES OF THE LELAND STANFORD JUNIOR UNIVERSITY (US) | 2011-01-13 | — | — | WO | disclosed |
| US-20110009356-A1 | NOVEL PHOSPHORUS-CONTAINING PRODRUGS | METABASIS THERAPEUTICS, INC. (US) | 2011-01-13 | — | — | US | disclosed |
| WO-2011005860-A2 | 5' PHOSPHATE MIMICS | ALNYLAM PHARMACEUTICALS, INC. (US) | 2011-01-13 | — | — | WO | disclosed |
| EP-2265729-A1 | TARGET AMPLIFICATION AND SEQUENCING WITH PRIMERS COMPRISING TRIPLEX FORMING MONOMER UNITS | Quantibact A/s (DK) | 2010-12-29 | — | — | EP | disclosed |
| US-7858772-B2 | Compounds and methods for synthesis and purification of oligonucleotides | ROCHE MOLECULAR SYSTEMS, INC. (US) | 2010-12-28 | — | — | US | disclosed |
| US-7816345-B2 | Phosphorus-containing prodrugs | METABASIS THERAPEUTICS, INC. (US) | 2010-10-19 | — | — | US | disclosed |
| US-7812180-B2 | Electropolymerisable monomers that are soluble in aqueous solution and electroactive probes that can be obtained with such monomers | BIOMERIEUX (FR) | 2010-10-12 | — | — | US | disclosed |
| US-20100213059-A1 | TRANSIENTLY BONDING DRAG-TAGS FOR SEPARATION MODALITIES | CARNEGIE MELLON UNIVERSITY (US) | 2010-08-26 | — | — | US | disclosed |
| WO-2010039543-A2 | SELF DELIVERING BIO-LABILE PHOSPHATE PROTECTED PRO-OLIGOS FOR OLIGONUCLEOTIDE BASED THERAPEUTICS AND MEDIATING RNA INTERFERENCE | TRAVERSA THERAPEUTICS, INC. (US) | 2010-04-08 | — | — | WO | disclosed |
| EP-2168973-A1 | Nucleic acid ligand complexes | Gilead Sciences, Inc. (US) | 2010-03-31 | — | — | EP | disclosed |
| EP-0824541-B1 | NUCLEIC ACID LIGAND COMPLEXES | GILEAD SCIENCES INC (US) | 2009-12-16 | — | — | EP | disclosed |
| US-7601851-B2 | Compounds and methods for fluorescent labeling | EPOCH BIOSCIENCES, INC. (US) | 2009-10-13 | — | — | US | disclosed |
| WO-2009112032-A1 | TARGET AMPLIFICATION AND SEQUENCING WITH PRIMERS COMPRISING TRIPLEX FORMING MONOMER UNITS | QUANTIBACT A/S (DK) | 2009-09-17 | — | — | WO | disclosed |
| EP-2097427-A1 | COMPOUNDS AND METHODS FOR SYNTHESIS AND PURIFICATION OF OLIGONUCLEOTIDES | Roche Diagnostics GmbH (DE) | 2009-09-09 | — | — | EP | disclosed |
| US-20090216003-A1 | STABLE AND SELECTIVE FORMATION OF HOOGSTEEN-TYPE TRIPLEXES AND DUPLEXES USING TWISTED INTERCALATING NUCLEIC ACIDS (TINA) AND PROCESS FOR THE PREPARATION OF TINA | TINA HOLDING APS (DK) | 2009-08-27 | — | — | US | disclosed |
| EP-1991705-A4 | COMPOUNDS AND METHODS FOR FLUORESCENT LABELING | EPOCH BIOSCIENCES INC (US) | 2009-07-01 | — | — | EP | disclosed |
| US-20090069263-A1 | 4'-THIOARABINONUCLEOTIDE-CONTAINING OLIGONUCLEOTIDES, COMPOUNDS AND METHODS FOR THEIR PREPARATION AND USES THEREOF | THE ROYAL INSTITUTION FOR THE ADVANCEMENT OF LEARNING/MCGILL UNIVERSITY (CA) | 2009-03-12 | — | — | US | disclosed |
| US-20090053826-A1 | Electropolymerisable monomers that are soluble in aqueous solution and electroactive probes that can be obtained with such monomers | BIOMERIEUX (FR) | 2009-02-26 | — | — | US | disclosed |
| EP-1991705-A2 | COMPOUNDS AND METHODS FOR FLUORESCENT LABELING | Epoch Biosciences, Inc. (US) | 2008-11-19 | — | — | EP | disclosed |
| US-20080274454-A1 | Reversible and Chemically Programmable Micelle Assembly With Dna Block-Copolymer Amphiphiles | NATIONAL SCIENCE FOUNDATION | 2008-11-06 | — | — | US | disclosed |
| US-20080268440-A1 | BIOMOLECULE IMMOBILIZATION ON SURFACE VIA HYDROPHOBIC INTERACTIONS | APPLIED BIOSYSTEMS, LLC | 2008-10-30 | — | — | US | disclosed |
| EP-1466176-A4 | COMPOUNDS AND METHODS FOR FLUORESCENT LABELING | EPOCH BIOSCIENCES INC (US) | 2008-10-01 | — | — | EP | disclosed |
| CN-101238213-A | Stable and selective formation of hoogsteen-type triplexes and duplexes using twisted intercalating nucleic acids (TINA) and process for the preparation of tina | TINA HOLDING APS (DK) | 2008-08-06 | — | — | CN | disclosed |
| WO-2008077600-A1 | COMPOUNDS AND METHODS FOR SYNTHESIS AND PURIFICATION OF OLIGONUCLEOTIDES | ROCHE DIAGNOSTICS GMBH (DE) | 2008-07-03 | — | — | WO | disclosed |
| US-20080161548-A1 | COMPOUNDS AND METHODS FOR SYNTHESIS AND PURIFICATION OF OLIGONUCLEOTIDES | ROCHE MOLECULAR SYSTEMS, INC. (US) | 2008-07-03 | — | — | US | disclosed |
| US-20080153135-A1 | Methods and apparatus for conducting amplification reactions on high density hydrophilic patterned microplates | APPLIED BIOSYSTEMS, INC. | 2008-06-26 | — | — | US | disclosed |
| US-20080153134-A1 | METHODS AND APPARATUS FOR GENERATING HYDROPHILIC PATTERNING OF HIGH DENSITY MICROPLATES USING AN AMPHIPHILIC POLYMER | APPLIED BIOSYSTEMS, INC. | 2008-06-26 | — | — | US | disclosed |
| US-7384925-B2 | 2' Hydroxy-3'-bromo-3,4,4',5-tetramethoxy-(Z)-stilbene; antimitotic agent; inhibits the assembly of tubulin into microtubules; anticarcinogenic: solid tumor cancers, neovascularization; tubulin-binding stilbenoid analogs structurally related to combretastatin A-1 and A-4 (extract from willow tree) | OXIGENE, INC. (US) | 2008-06-10 | — | — | US | disclosed |
| US-20080125605-A1 | Novel Phosphorus-Containing Prodrugs | METABASIS THERAPEUTICS, INC. | 2008-05-29 | — | — | US | disclosed |
| US-7351399-B2 | Prodrugs for phosphorus-containing compounds | METABASIS THERAPEUTICS, INC. (US) | 2008-04-01 | — | — | US | disclosed |
| EP-1888748-A2 | STABLE AND SELECTIVE FORMATION OF HOOGSTEEN-TYPE TRIPLEXES AND DUPLEXES USING TWISTED INTERCALATING NUCLEIC ACIDS (TINA) AND PROCESS FOR THE PREPARATION OF TINA | Tina Holding ApS (DK) | 2008-02-20 | — | — | EP | disclosed |
| US-20070249564-A1 | Novel phosphorus-containing prodrugs | METABASIS THERAPEUTICS, INC. (US) | 2007-10-25 | — | — | US | disclosed |
| WO-2007098336-A2 | COMPOUNDS AND METHODS FOR FLUORESCENT LABELING | EPOCH BIOSCIENCES, INC. (US) | 2007-08-30 | — | — | WO | disclosed |
| WO-2007068113-A1 | 4'-THIOARABINONUCLEOTIDE-CONTAINING OLIGONUCLEOTIDES, COMPOUNDS AND METHODS FOR THEIR PREPARATION AND USES THEREOF | MCGILL UNIVERSITY (CA) | 2007-06-21 | — | — | WO | disclosed |
| EP-0824541-A4 | NUCLEIC ACID LIGAND COMPLEXES | GILEAD SCIENCES INC (US) | 2007-04-18 | — | — | EP | disclosed |
| US-7205404-B1 | Phosphorus-containing prodrugs | METABASIS THERAPEUTICS, INC. (US) | 2007-04-17 | — | — | US | disclosed |
| EP-1165570-B9 | NOVEL PHOSPHORUS-CONTAINING PRODRUGS | METABASIS THERAPEUTICS INC (US) | 2007-02-21 | — | — | EP | disclosed |
| WO-2006125447-A2 | STABLE AND SELECTIVE FORMATION OF HOOGSTEEN-TYPE TRIPLEXES AND DUPLEXES USING TWISTED INTERCALATING NUCLEIC ACIDS (TINA) AND PROCESS FOR THE PREPARATION OF TINA | TINA HOLDING APS (DK) | 2006-11-30 | — | — | WO | disclosed |
| EP-1724276-A1 | Novel phosphorus-containing prodrugs | Metabasis Therapeutics, Inc. (US) | 2006-11-22 | — | — | EP | disclosed |
| US-7112684-B2 | Compounds and methods for fluorescent labeling | EPOCH BIOSCIENCES, INC. (US) | 2006-09-26 | — | — | US | disclosed |
| US-20060204990-A1 | Compounds and methods for fluorescent labeling | EPOCH BIOSCIENCES, INC. (US) | 2006-09-14 | — | — | US | disclosed |
| EP-1165570-B1 | NOVEL PHOSPHORUS-CONTAINING PRODRUGS | METABASIS THERAPEUTICS INC (US) | 2006-08-23 | — | — | EP | disclosed |
| EP-0904275-B1 | PREPARATION OF PHOSPHOROTHIOATE OLIGOMERS | UNIV MCGILL (CA) | 2006-05-17 | — | — | EP | disclosed |
| EP-1438281-A4 | FUNCTIONALIZED STILBENE DERIVATIVES AS IMPROVED VASCULAR TARGETING AGENTS | OXIGENE INC (US) | 2006-04-26 | — | — | EP | disclosed |
| EP-1634886-A2 | Novel phosphorus-containing prodrug | Metabasis Therapeutics, Inc. (US) | 2006-03-15 | — | — | EP | disclosed |
| US-20060035868-A1 | Functionalized stilbene derivatives as improved vascular targeting agents | MATEON THERAPEUTICS, INC. | 2006-02-16 | — | — | US | disclosed |
| US-20050288240-A1 | Novel-prodrugs for phosphorus-containing compounds | ERION MARK D | 2005-12-29 | — | — | US | disclosed |
| CN-1714094-A | Cardiolipin compositions their methods of preparation and use | NEOPHARM INC (US) | 2005-12-28 | — | — | CN | disclosed |
| US-20050277144-A1 | Compounds and methods for fluorescent labeling | EPOCH BIOSCIENCES, INC. (US) | 2005-12-15 | — | — | US | disclosed |
| US-6972339-B2 | Compounds and methods for fluorescent labeling | EPOCH BIOSCIENCES, INC. (US) | 2005-12-06 | — | — | US | disclosed |
| WO-2005108614-A2 | REVERSIBLE AND CHEMICALLY PROGRAMMABLE MICELLE ASSEMBLY WITH DNA BLOCK-COPOLYMER AMPHIPHILES | NORTHWESTERN UNIVERSITY (US) | 2005-11-17 | — | — | WO | disclosed |
| US-6965041-B1 | N-acylphosphoramidites and their use in oligonucleotide synthesis | THE UNITED STATES OF AMERICA AS REPRESENTED BY THE DEPARTMENT OF HEALTH AND HUMAN SERVICES (US) | 2005-11-15 | — | — | US | disclosed |
| US-6946115-B2 | Prodrugs for phosphorus-containing compounds | METABASIS THERAPEUTICS, INC. (US) | 2005-09-20 | — | — | US | disclosed |
| US-20050181037-A1 | Cardiolipin compositions their methods of preparation and use | NEOPHARM, INC. (US) | 2005-08-18 | — | — | US | disclosed |
| US-20050176066-A1 | Compounds and methods for fluorescent labeling | EPOCH BIOSCIENCES, INC. (US) | 2005-08-11 | — | — | US | disclosed |
| US-20050171340-A1 | COMPOUNDS AND METHODS FOR FLUORESCENT LABELING | EPOCH BIOSCIENCES, INC. (US) | 2005-08-04 | — | — | US | disclosed |
| US-20050164974-A1 | Nucleic acid ligand complexes | THE REGENTS OF THE UNIVERSITY OF COLORADO, SUCCESSOR IN INTEREST TO UNIVERSITY RESEARCH CORPORATION AND/OR UNIVERSITY LICENSE EQUITY HOLDINGS, INC. | 2005-07-28 | — | — | US | disclosed |
| US-6919324-B2 | For therapy of solid tumor cancers and other diseases associated with unwanted neovascularization | OXIGENE, INC. (US) | 2005-07-19 | — | — | US | disclosed |
| EP-1534420-A1 | HIGH DENSITY ARRAYS | SurModics, Inc. (US) | 2005-06-01 | — | — | EP | disclosed |
| EP-1513853-A2 | CARDIOLIPIN COMPOSITIONS, METHODS OF PREPARATION AND USE | Neopharm, Inc. (US) | 2005-03-16 | — | — | EP | disclosed |
| US-20050053970-A1 | Methods and compositions for identifying peptide aptamers capable of altering a cell phenotype | ENANTA PHARMACEUTICALS, INC. | 2005-03-10 | — | — | US | disclosed |
| US-6861518-B2 | Hybrid oligonucleotide | MCGILL UNIVERSITY (CA) | 2005-03-01 | — | — | US | disclosed |
| EP-1466176-A2 | COMPOUNDS AND METHODS FOR FLUORESCENT LABELING | Epoch Biosciences, Inc. (US) | 2004-10-13 | — | — | EP | disclosed |
| US-6800768-B1 | STABLE PHOTOACTIVE COUMARIN COMPOUNDS THAT CAN BE USED AS PHOTO-CROSSLINKING REAGENTS IN NUCLEIC ACID HYBRIDIZATION ASSAYS AND THERAPEUTIC APPLICATIONS | NAXCOR, INC. | 2004-10-05 | — | — | US | disclosed |
| WO-2004062569-A2 | CARDIOLIPIN COMPOSITIONS THEIR METHODS OF PREPARATION AND USE | NEOPHARM, INC. (US) | 2004-07-29 | — | — | WO | disclosed |
| EP-1438281-A2 | FUNCTIONALIZED STILBENE DERIVATIVES AS IMPROVED VASCULAR TARGETING AGENTS | Oxigene, Inc. (US) | 2004-07-21 | — | — | EP | disclosed |
| US-6762298-B2 | DEPROTECTING AN OLIGONUCLEOTIDE BY HEATING IN A FLUID, WHERE THE PHOSPHORUS ATOM IS O-PROTECTED WITH A THERMOLABILE GROUP SUCH AS (PYRROLIDIN-1-ONE-1-YL)ALKYL; SYNTHESIS OF OLIGONUCLEOTIDES | THE UNITED STATES OF AMERICA AS REPRESENTED BY THE DEPARTMENT OF HEALTH AND HUMAN SERVICES | 2004-07-13 | — | — | US | disclosed |
| WO-2004050231-A2 | (BIO) ORGANIC OLIGOMERS FOR THE PREPARATION OF MACROMOLECULES | AARHUS UNIVERSITET (DK) | 2004-06-17 | — | — | WO | disclosed |
| US-20040097722-A9 | Preparation of phosphorothioate oligomers | MCGILL UNIVERSITY | 2004-05-20 | — | — | US | disclosed |
| WO-2004022703-A2 | NON-NUCLEOSIDIC COUMARIN DERIVATIVES AS POLYNUCLEOTIDE-CROSSLINKING AGENTS | NAXCOR, INC. (US) | 2004-03-18 | — | — | WO | disclosed |
| WO-2004020085-A1 | HIGH DENSITY ARRAYS | SURMODICS, INC. (US) | 2004-03-11 | — | — | WO | disclosed |
| US-20030229219-A1 | Preparation of phosphorothioate oligomers | ISIS PHARMACEUTICALS, INC. | 2003-12-11 | — | — | US | disclosed |
| WO-2003099830-A2 | CARDIOLIPIN COMPOSITIONS, METHODS OF PREPARATION AND USE | NEOPHARM, INC. (US) | 2003-12-04 | — | — | WO | disclosed |
| WO-2003087188-A1 | OLIGONUCLEOTIDE-MODIFIED ROMP POLYMERS AND CO-POLYMERS | NANOSPHERE, INC. (US) | 2003-10-23 | — | — | WO | disclosed |
| US-20030149003-A1 | Functionalized stilbene derivatives as improved vascular targeting agents | MATEON THERAPEUTICS, INC. | 2003-08-07 | — | — | US | disclosed |
| US-6596857-B1 | Oligomer for use as tool in human diagnostics and therapeutics | MCGILL UNIVERSITY (CA) | 2003-07-22 | — | — | US | disclosed |
| US-20030125263-A1 | Nucleic acid ligand complexes | GILEAD SCIENCES, INC. (US) | 2003-07-03 | — | — | US | disclosed |
| US-20030113740-A1 | Oligonucleotide-modified ROMP polymers and co-polymers | NORTHWESTERN UNIVERSITY | 2003-06-19 | — | — | US | disclosed |
| US-20030114660-A1 | Preparation of phosphorothioate oligomers | JUST GEORGE (CA) | 2003-06-19 | — | — | US | disclosed |
| WO-2003040168-A2 | METHODS AND COMPOSITIONS FOR IDENTIFYING PEPTIDE APTAMERS CAPABLE OF ALTERING A CELL PHENOTYPE | ENANTA PHARMACEUTICALS, INC. (US) | 2003-05-15 | — | — | WO | disclosed |
| EP-0990047-B1 | METHODS AND COMPOSITIONS FOR ANALYZING NUCLEIC ACIDS BY MASS SPECTROMETRY | QIAGEN GENOMICS INC (US) | 2003-05-14 | — | — | EP | disclosed |
| US-20030082604-A1 | High density arrays | SURMODICS, INC. | 2003-05-01 | — | — | US | disclosed |
| WO-2003035008-A2 | FUNCTIONALIZED STILBENE DERIVATIVES AS IMPROVED VASCULAR TARGETING AGENTS | OXIGENE, INC. (US) | 2003-05-01 | — | — | WO | disclosed |
| WO-2003023357-A2 | COMPOUNDS AND METHODS FOR FLUORESCENT LABELING | EPOCH BIOSCIENCES, INC. (US) | 2003-03-20 | — | — | WO | disclosed |
| US-6476216-B1 | Preparation of phosphorothioate oligomers | MCGILL UNIVERSITY (CA) | 2002-11-05 | — | — | US | disclosed |
| US-6465188-B1 | PARTITIONING, GENETIC REPLICATION; SELEX | GILEAD SCIENCES, INC. | 2002-10-15 | — | — | US | disclosed |
| US-20020052345-A1 | Novel prodrugs for phosphorus-containing compounds | METABASIS THERAPEUTICS, INC. | 2002-05-02 | — | — | US | disclosed |
| EP-1178999-A2 | L-RIBO-LNA ANALOGUES | Exiqon A/S (DK) | 2002-02-13 | — | — | EP | disclosed |
| EP-1165570-A2 | NOVEL PHOSPHORUS-CONTAINING PRODRUGS | Metabasis Therapeutics, Inc. (US) | 2002-01-02 | — | — | EP | disclosed |
| EP-1165575-A1 | PHOSPHATE CONTAINING MACROCYCLIC IMMUNOMODULATORS | ABBOTT LABORATORIES (US) | 2002-01-02 | — | — | EP | disclosed |
| EP-1163251-A1 | N-ACYLPHOSPHORAMIDITES AND THEIR USE IN OLIGONUCLEOTIDE SYNTHESIS | THE GOVERNMENT OF THE UNITED STATES OF AMERICA, as represented by THE SECRETARY, DEPARTMENT OF HEALTH AND HUMAN SERVICES (US) | 2001-12-19 | — | — | EP | disclosed |
| US-20010044529-A1 | Thermolabile phosphorus protecting groups, associated intermediates and methods of use | GOVERNMENT OF THE UNITED STATES OF AMERICA, REPRESENTED BY THE SECRETARY, DEPARTMENT OF HEALTH AND HUMAN SERVICES | 2001-11-22 | — | — | US | disclosed |
| US-6312662-B1 | CONVERSION BY HUMAN LIVER MICROSOMES TO MPO3H2 | METABASIS THERAPEUTICS, INC. | 2001-11-06 | — | — | US | disclosed |
| EP-1060182-A2 | NOVEL PRODRUGS FOR PHOSPHORUS-CONTAINING COMPOUNDS | Metabasis Therapeutics, Inc. (US) | 2000-12-20 | — | — | EP | disclosed |
| US-6160109-A | Preparation of phosphorothioate and boranophosphate oligomers | ISIS PHARMACEUTICALS, INC. (US) | 2000-12-12 | — | — | US | disclosed |
| EP-1051424-A1 | NOVEL SYNTHONS FOR OLIGONUCLEOTIDE SYNTHESIS | HYBRIDON, INC. (US) | 2000-11-15 | — | — | EP | disclosed |
| US-6147204-A | COMPLEX FOR TARGETING THERAPEUTIC OR DIAGNOSTIC AGENTS TO PREFERENTIAL BIOLOGICAL TARGET | NEXSTAR PHARMACEUTICALS, INC. (US) | 2000-11-14 | — | — | US | disclosed |
| WO-2000066604-A2 | L-RIBO-LNA ANALOGUES | EXIQON A/S (DK) | 2000-11-09 | — | — | WO | disclosed |
| WO-2000058318-A1 | PHOSPHATE CONTAINING MACROCYCLIC IMMUNOMODULATORS | ABBOTT LABORATORIES (US) | 2000-10-05 | — | — | WO | disclosed |
| WO-2000056749-A1 | N-ACYLPHOSPHORAMIDITES AND THEIR USE IN OLIGONUCLEOTIDE SYNTHESIS | THE GOVERNMENT OF THE UNITED STATES OF AMERICA, REPRESENTED BY THE SECRETARY, DEPARTMENT OF HEALTH AND HUMAN SERVICES (US) | 2000-09-28 | — | — | WO | disclosed |
| US-6117993-A | Synthons for oligonucleotide synthesis | HYBRIDON, INC. (US) | 2000-09-12 | — | — | US | disclosed |
| WO-2000052015-A2 | NOVEL PHOSPHORUS-CONTAINING PRODRUGS | METABASIS THERAPEUTICS, INC. (US) | 2000-09-08 | — | — | WO | disclosed |
| US-6107039-A | MIXING SAMPLE OF NUCLEIC ACID SEQUENCE TO BE ANALYZED WITH OLIGONUCLEOTIDE PROBE CONTAINING AT LEAST ONE THIOL-PROTECTED PYRIMIDINE NUCLEOTIDE, EXPOSING TO ENDONUCLEASE, AND IDENTIFYING FRAGMENTS HAVING HYBRIDIZED PROBE | THE BOARD OF REGENTS OF THE UNIVERSITY OF OKLAHOMA | 2000-08-22 | — | — | US | disclosed |
| EP-0836612-B1 | NOVEL SYNTHONS FOR STEREOSELECTIVE OLIGONUCLEOTIDE SYNTHESIS | HYBRIDON INC (US) | 2000-07-26 | — | — | EP | disclosed |
| EP-1015469-A2 | BI- AND TRI-CYCLIC NUCLEOSIDE, NUCLEOTIDE AND OLIGONUCLEOIDE ANALOGUES | Exiqon A/S (DK) | 2000-07-05 | — | — | EP | disclosed |
| EP-0990047-A2 | METHODS AND COMPOSITIONS FOR ANALYZING NUCLEIC ACID MOLECULES UTILIZING SIZING TECHNIQUES | Rapigene, Inc. (US) | 2000-04-05 | — | — | EP | disclosed |
| WO-1999045016-A9 | NOVEL PRODRUGS FOR PHOSPHORUS-CONTAINING COMPOUNDS | METABASIS THERAPEUTICS INC (US) | 2000-03-02 | — | — | WO | disclosed |
| US-6031092-A | Preparation of phosphorothioate oligomers | MC GILL UNIVERSITY (CA) | 2000-02-29 | — | — | US | disclosed |
| WO-2000000499-A1 | METHOD FOR PREPARING OLIGONUCLEOTIDES WITH BORANOPHOSPHATE LINKAGES | ISIS PHARMACEUTICALS, INC. (US) | 2000-01-06 | — | — | WO | disclosed |
| US-6011020-A | THERAPEUTIC OR DIAGNOSTIC COMPLEX COMPRISED OF A NUCLEIC ACID LIGAND AND A POLYETHYLENE GLYCOL (PEG), WHEREIN SAID NUCLEIC ACID LIGAND IS COVALENTLY LINKED TO SAID PEG | NEXSTAR PHARMACEUTICALS, INC. (US) | 2000-01-04 | — | — | US | disclosed |
| US-6008334-A | MODIFIED PYRIMIDINE NUCLEOSIDES/NUCLEOTIDES WITH PROTECTED THIOL GROUP ATTACHED AT 5 POSITION OF BASE THAT IS NOT INVOLVED IN WATSON-CRICK BASE PARING; FOR USE IN CHEMICAL AND ENZYMATIC SYNTHESIS OF NUCLEIC ACIDS | THE BOARD OF REGENTS OF THE UNIVERSITY OF OKLAHOMA (US) | 1999-12-28 | — | — | US | disclosed |
| US-6005093-A | CONMPOUNDS USED AS REPLACEMENTS FOR ONE OR MORE COMPLEMENTARY NUCLEOSIDE BASES IN PROBES; ENABLE PHOTOACTIVE CROSSLINKING OF NUCLEIC ACID STRANDS IN HYBRIDIZATION ASSAYS AND THERAPEUTIC APPLICATIONS | NAXCOR (US) | 1999-12-21 | — | — | US | disclosed |
| WO-1999045016-A2 | NOVEL PRODRUGS FOR PHOSPHORUS-CONTAINING COMPOUNDS | METABASIS THERAPEUTICS, INC. (US) | 1999-09-10 | — | — | WO | disclosed |
| US-5945521-A | Preparation of phosphorothioate oligomers | MCGILL UNIVERSITY (CA) | 1999-08-31 | — | — | US | disclosed |
| WO-1999038878-A1 | NOVEL SYNTHONS FOR OLIGONUCLEOTIDE SYNTHESIS | HYBRIDON, INC. (US) | 1999-08-05 | — | — | WO | disclosed |
| WO-1999005319-A9 | METHODS AND COMPOUNDS FOR ANALYZING NUCLEIC ACIDS BY MASS SPECTROMETRY | RAPIGENE INC (US) | 1999-06-17 | — | — | WO | disclosed |
| EP-0904275-A1 | PREPARATION OF PHOSPHOROTHIOATE OLIGOMERS | McGILL UNIVERSITY (CA) | 1999-03-31 | — | — | EP | disclosed |
| WO-1999014226-A2 | BI- AND TRI-CYCLIC NUCLEOSIDE, NUCLEOTIDE AND OLIGONUCLEOTIDE ANALOGUES | EXIQON A/S (DK) | 1999-03-25 | — | — | WO | disclosed |
| WO-1999005319-A2 | METHODS AND COMPOUNDS FOR ANALYZING NUCLEIC ACIDS BY MASS SPECTROMETRY | RAPIGENE, INC. (US) | 1999-02-04 | — | — | WO | disclosed |
| US-5807837-A | ADMINISTERING TO TREAT HIV INFECTIONS TO INHIBIT THE REPLICATION OF FOREIGN NUCLEIC ACIDS IN A NORMAL CELL | SANKYO COMPANY, LIMITED (JP) | 1998-09-15 | — | — | US | disclosed |
| EP-0827501-A4 | NON-NUCLEOSIDIC COUMARIN DERIVATIVES AS POLYNUCLEOTIDE-CROSS-LINKING AGENTS | NAXCOR (US) | 1998-06-10 | — | — | EP | disclosed |
| WO-1998003532-A9 | BASE-PROTECTED NUCLEOTIDE ANALOGS WITH PROTECTED THIOL GROUPS | — | 1998-05-28 | — | — | WO | disclosed |
| US-5750674-A | Methods and compounds for the stereoselective enrichment of oligonucleotide diastereomers and oligonucleotides thereby produced | HYBRIDON, INC. (US) | 1998-05-12 | — | — | US | disclosed |
| EP-0836612-A1 | NOVEL SYNTHONS FOR STEREOSELECTIVE OLIGONUCLEOTIDE SYNTHESIS | HYBRIDON, Inc. (US) | 1998-04-22 | — | — | EP | disclosed |
| US-5734041-A | Preparation of chiral phosphorothioate oligomers | MCGILL UNIVERSITY (CA) | 1998-03-31 | — | — | US | disclosed |
| EP-0827501-A1 | NON-NUCLEOSIDIC COUMARIN DERIVATIVES AS POLYNUCLEOTIDE-CROSS-LINKING AGENTS | NAXCOR (US) | 1998-03-11 | — | — | EP | disclosed |
| EP-0824541-A1 | NUCLEIC ACID LIGAND COMPLEXES | NeXstar Pharmaceuticals, Inc. (US) | 1998-02-25 | — | — | EP | disclosed |
| US-5674856-A | TREATMENT AND PROPHYLAXIS OF VIRAL INFECTIONS, INCLUDING AIDS AND TUMORS | SANKYO COMPANY, LIMITED (JP) | 1997-10-07 | — | — | US | disclosed |
| WO-1997014710-A1 | PREPARATION OF PHOSPHOROTHIOATE OLIGOMERS | MCGILL UNIVERSITY (US) | 1997-04-24 | — | — | WO | disclosed |
| EP-0611075-B1 | Modified oligodeoxyribonucleotides, their preparation and their therapeutic use | SANKYO CO (JP) | 1996-12-18 | — | — | EP | disclosed |
| WO-1996039413-A1 | METHODS AND COMPOUNDS FOR THE SYNTHESIS OF OLIGONUCLEOTIDES AND THE OLIGONUCLEOTIDES THEREBY PRODUCED | HYBRIDON, INC. (US) | 1996-12-12 | — | — | WO | disclosed |
| WO-1996037504-A1 | NOVEL SYNTHONS FOR STEREOSELECTIVE OLIGONUCLEOTIDE SYNTHESIS | HYBRIDON, INC. (US) | 1996-11-28 | — | — | WO | disclosed |
| WO-1996034876-A1 | NUCLEIC ACID LIGAND COMPLEXES | NEXSTAR PHARMACEUTICALS, INC. (US) | 1996-11-07 | — | — | WO | disclosed |
| WO-1996028438-A1 | NON-NUCLEOSIDIC COUMARIN DERIVATIVES AS POLYNUCLEOTIDE-CROSS-LINKING AGENTS | NAXCOR (US) | 1996-09-19 | — | — | WO | disclosed |
| US-5380835-A | Chemically phosphorylating the 5'-hydroxyl terminus of an oligonucleotide | ABBOTT LABORATORIES (US) | 1995-01-10 | — | — | US | disclosed |
| EP-0611075-A1 | Modified oligodeoxyribonucleotides, their preparation and their therapeutic use | SANKYO COMPANY LIMITED (JP) | 1994-08-17 | — | — | EP | disclosed |
| EP-0591302-A4 | — | — | 1994-08-03 | — | — | EP | disclosed |
| EP-0591344-A4 | — | — | 1994-08-03 | — | — | EP | disclosed |
| EP-0592534-A4 | SILYL PHOSPHORYLATING REAGENTS AND METHODS OF USING THEM | ABBOTT LAB (US) | 1994-07-06 | — | — | EP | disclosed |
| EP-0592534-A1 | SILYL PHOSPHORYLATING REAGENTS AND METHODS OF USING THEM | ABBOTT LABORATORIES (US) | 1994-04-20 | — | — | EP | disclosed |
| EP-0591344-A1 | A PROCESS FOR SYNTHESIS OF SILYL ALCOHOLS | ABBOTT LABORATORIES (US) | 1994-04-13 | — | — | EP | disclosed |
| EP-0591302-A1 | SUBSTITUTED SILYL ALCOHOLS | ABBOTT LABORATORIES (US) | 1994-04-13 | — | — | EP | disclosed |
| WO-1994001445-A1 | BASE-PROTECTED NUCLEOTIDE ANALOGS WITH PROTECTED THIOL GROUPS | RESEARCH CORPORATION TECHNOLOGIES, INC. (US) | 1994-01-20 | — | — | WO | disclosed |
| EP-0558749-A1 | ANTISENSE NUCLEIC ACID DERIVATIVE | SANKYO COMPANY LIMITED (JP) | 1993-09-08 | — | — | EP | disclosed |
| JP-H05213986-A | ANTISENSE NUCLEIC ACID DERIVATIVE | SANKYO CO LTD | 1993-08-24 | — | — | JP | disclosed |
| WO-1992022557-A1 | SUBSTITUTED SILYL ALCOHOLS | ABBOTT LABORATORIES (US) | 1992-12-23 | — | — | WO | disclosed |
| WO-1992022561-A1 | A PROCESS FOR SYNTHESIS OF SILYL ALCOHOLS | ABBOTT LABORATORIES (US) | 1992-12-23 | — | — | WO | disclosed |
| WO-1992021689-A1 | SILYL PHOSPHORYLATING REAGENTS AND METHODS OF USING THEM | ABBOTT LABORATORIES (US) | 1992-12-10 | — | — | WO | disclosed |
| US-5159095-A | Reagant for phosphorylating oligonucleotides | ABBOTT LABORATORIES (US) | 1992-10-27 | — | — | US | disclosed |
| US-5113005-A | Hydrosilation | ABBOTT LABORATORIES (US) | 1992-05-12 | — | — | US | disclosed |
| JP-H03188088-A | NOVEL LYSOPHOSPHATIDYLSERINE | AJINOMOTO CO INC | 1991-08-16 | — | — | JP | disclosed |
| JP-H03188088-A | NOVEL LYSOPHOSPHATIDYLSERINE | AJINOMOTO CO INC | 1991-08-16 | — | — | JP | disclosed |