Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | TP53 | P04637 | 2/20 | 0.43 |
| ▸ | SMPD1 | P17405 | 1/20 | 0.43 |
| ▸ | KDM4E | B2RXH2 | 2/20 | 0.42 |
| ▸ | ALDH1A1 | P00352 | 2/20 | 0.42 |
| ▸ | HPGD | P15428 | 1/20 | 0.42 |
| ▸ | SMN1; SMN2 | Q16637 | 1/20 | 0.42 |
| ▸ | PTGS2 | P35354 | 1/20 | 0.41 |
| ▸ | THRB | P10828 | 1/20 | 0.41 |
| ▸ | RXFP1 | Q9HBX9 | 1/20 | 0.41 |
| ▸ | LMNA | P02545 | 1/20 | 0.40 |
| ▸ | MEN1 | O00255 | 1/20 | 0.39 |
| ▸ | KMT2A | Q03164 | 1/20 | 0.39 |
| ▸ | NTRK1 | P04629 | 1/20 | 0.39 |
| ▸ | PIM1 | P11309 | 1/20 | 0.39 |
| ▸ | GABRP | O00591 | 1/20 | 0.39 |
| ▸ | GABRD | O14764 | 1/20 | 0.39 |
| ▸ | CYP1A2 | P05177 | 1/20 | 0.39 |
| ▸ | CYP2D6 | P10635 | 1/20 | 0.39 |
| ▸ | CYP2C9 | P11712 | 1/20 | 0.39 |
| ▸ | GABRA1 | P14867 | 1/20 | 0.39 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL6257620 | 0.93 | TP53 (0.44) | TP53KDM4EALDH1A1HPGDSMN1; SMN2 | |
| SCHEMBL6260962 | 0.89 | TP53 (0.53) | TP53KDM4EALDH1A1HPGDSMN1; SMN2 | |
| SCHEMBL6259201 | 0.83 | KDM4E (0.43) | TP53KDM4EALDH1A1HPGDSMN1; SMN2 | |
| SCHEMBL6256500 | 0.81 | CYP1A2 (0.53) | TP53KDM4EALDH1A1HPGDSMN1; SMN2 | |
| SCHEMBL6254733 | 0.81 | PTGIR (0.50) | TP53KDM4EALDH1A1HPGD | |
| SCHEMBL6255253 | 0.80 | PTGIR (0.46) | TP53KDM4EALDH1A1HPGDPOLB | |
| SCHEMBL6276770 | 0.79 | PTGIR (0.46) | TP53KDM4EALDH1A1HPGDMEN1 | |
| SCHEMBL6256001 | 0.79 | GRIA2 (0.44) | KDM4EALDH1A1HPGDSMN1; SMN2RXFP1 | |
| SCHEMBL6255329 | 0.77 | SRC (0.48) | TP53ALDH1A1SMN1; SMN2LMNANTRK1 | |
| SCHEMBL6256484 | 0.73 | KDM4E (0.43) | TP53KDM4EALDH1A1HPGDSMN1; SMN2 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 3 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-1156039-B1 | PYRIDAZIN-3-ONE DERIVATIVES AND MEDICINES CONTAINING THE SAME | KOWA CO (JP) | 2005-10-05 | — | — | EP | disclosed |
| US-6680316-B1 | INTERLEUKIN INHIBITORS; AUTOIMMUNE, RHEUMATIC, AND GASTROINTESTINAL DISORDERS; OSTEOPOROSIS; ANTIINFLAMMATORY, ANTIISCHEMIC, AND ANTIARTHRITIC AGENTS | KOWA CO., LTD. (JP) | 2004-01-20 | — | — | US | disclosed |
| EP-1156039-A1 | PYRIDAZIN-3-ONE DERIVATIVES AND MEDICINES CONTAINING THE SAME | Kowa Co., Ltd. (JP) | 2001-11-21 | — | — | EP | disclosed |