Predicted protein targets (top 19)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | KDM4E | B2RXH2 | 3/20 | 0.43 |
| ▸ | ALDH1A1 | P00352 | 3/20 | 0.43 |
| ▸ | HPGD | P15428 | 2/20 | 0.43 |
| ▸ | SMN1; SMN2 | Q16637 | 2/20 | 0.43 |
| ▸ | PSMB1 | P20618 | 1/20 | 0.43 |
| ▸ | PSMB5 | P28074 | 1/20 | 0.43 |
| ▸ | KMT2A | Q03164 | 3/20 | 0.42 |
| ▸ | MEN1 | O00255 | 2/20 | 0.42 |
| ▸ | TP53 | P04637 | 3/20 | 0.41 |
| ▸ | LMNA | P02545 | 1/20 | 0.41 |
| ▸ | PTGS1 | P23219 | 1/20 | 0.41 |
| ▸ | PTGS2 | P35354 | 1/20 | 0.41 |
| ▸ | PDE3A | Q14432 | 1/20 | 0.41 |
| ▸ | EDNRB | P24530 | 2/20 | 0.41 |
| ▸ | GAA | P10253 | 2/20 | 0.41 |
| ▸ | GLA | P06280 | 1/20 | 0.41 |
| ▸ | ATM | Q13315 | 1/20 | 0.40 |
| ▸ | L3MBTL1 | Q9Y468 | 1/20 | 0.40 |
| ▸ | POLB | P06746 | 1/20 | 0.40 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL6259201 | 0.90 | KDM4E (0.43) | KDM4EALDH1A1HPGDSMN1; SMN2PSMB1 | |
| SCHEMBL6254976 | 0.88 | KDM4E (0.41) | KDM4EALDH1A1HPGDSMN1; SMN2PSMB1 | |
| SCHEMBL6254981 | 0.88 | KDM4E (0.48) | KDM4EALDH1A1HPGDSMN1; SMN2PSMB1 | |
| SCHEMBL6257629 | 0.87 | POLB (0.56) | KDM4EALDH1A1HPGDSMN1; SMN2KMT2A | |
| SCHEMBL6258095 | 0.85 | AURKA (0.49) | KDM4ESMN1; SMN2TP53LMNA | |
| SCHEMBL6258294 | 0.83 | EDNRB (0.53) | KDM4EALDH1A1HPGDSMN1; SMN2KMT2A | |
| SCHEMBL6258728 | 0.82 | PIK3CD (0.44) | KDM4EALDH1A1HPGDKMT2AMEN1 | |
| SCHEMBL6260924 | 0.82 | MEN1 (0.43) | KDM4EALDH1A1HPGDSMN1; SMN2PSMB1 | |
| SCHEMBL6260226 | 0.82 | SRC (0.46) | ALDH1A1SMN1; SMN2KMT2AMEN1TP53 | |
| SCHEMBL6258726 | 0.82 | PTGIR (0.53) | KDM4EALDH1A1HPGDSMN1; SMN2PSMB5 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 3 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-1156039-B1 | PYRIDAZIN-3-ONE DERIVATIVES AND MEDICINES CONTAINING THE SAME | KOWA CO (JP) | 2005-10-05 | — | — | EP | disclosed |
| US-6680316-B1 | INTERLEUKIN INHIBITORS; AUTOIMMUNE, RHEUMATIC, AND GASTROINTESTINAL DISORDERS; OSTEOPOROSIS; ANTIINFLAMMATORY, ANTIISCHEMIC, AND ANTIARTHRITIC AGENTS | KOWA CO., LTD. (JP) | 2004-01-20 | — | — | US | disclosed |
| EP-1156039-A1 | PYRIDAZIN-3-ONE DERIVATIVES AND MEDICINES CONTAINING THE SAME | Kowa Co., Ltd. (JP) | 2001-11-21 | — | — | EP | disclosed |