Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | KDM4E | B2RXH2 | 2/20 | 0.43 |
| ▸ | ALDH1A1 | P00352 | 2/20 | 0.43 |
| ▸ | HPGD | P15428 | 1/20 | 0.43 |
| ▸ | TP53 | P04637 | 3/20 | 0.41 |
| ▸ | PSMB1 | P20618 | 1/20 | 0.40 |
| ▸ | PSMB5 | P28074 | 1/20 | 0.40 |
| ▸ | SMN1; SMN2 | Q16637 | 2/20 | 0.40 |
| ▸ | SRC | P12931 | 2/20 | 0.39 |
| ▸ | NTRK1 | P04629 | 1/20 | 0.39 |
| ▸ | PIM1 | P11309 | 1/20 | 0.39 |
| ▸ | MEN1 | O00255 | 1/20 | 0.39 |
| ▸ | KMT2A | Q03164 | 1/20 | 0.39 |
| ▸ | POLB | P06746 | 1/20 | 0.39 |
| ▸ | GAA | P10253 | 1/20 | 0.39 |
| ▸ | FGFR1 | P11362 | 1/20 | 0.39 |
| ▸ | FGFR2 | P21802 | 1/20 | 0.39 |
| ▸ | FGFR4 | P22455 | 1/20 | 0.39 |
| ▸ | FGFR3 | P22607 | 1/20 | 0.39 |
| ▸ | CCNE2 | O96020 | 1/20 | 0.39 |
| ▸ | CDK4 | P11802 | 1/20 | 0.39 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL6256484 | 0.90 | KDM4E (0.43) | KDM4EALDH1A1HPGDTP53PSMB1 | |
| SCHEMBL6260962 | 0.87 | TP53 (0.53) | KDM4EALDH1A1HPGDTP53SMN1; SMN2 | |
| SCHEMBL6254981 | 0.87 | KDM4E (0.48) | KDM4EALDH1A1HPGDTP53PSMB1 | |
| SCHEMBL6254976 | 0.87 | KDM4E (0.41) | KDM4EALDH1A1HPGDTP53PSMB1 | |
| SCHEMBL7730189 | 0.86 | MEN1 (0.44) | KDM4EALDH1A1HPGDPSMB1PSMB5 | |
| SCHEMBL6257629 | 0.86 | POLB (0.56) | KDM4EALDH1A1HPGDTP53SMN1; SMN2 | |
| SCHEMBL6257620 | 0.85 | TP53 (0.44) | KDM4EALDH1A1HPGDTP53SMN1; SMN2 | |
| SCHEMBL6257619 | 0.83 | TP53 (0.43) | KDM4EALDH1A1HPGDTP53SMN1; SMN2 | |
| SCHEMBL6255329 | 0.82 | SRC (0.48) | ALDH1A1TP53SMN1; SMN2SRCNTRK1 | |
| SCHEMBL6258095 | 0.82 | AURKA (0.49) | KDM4ETP53SMN1; SMN2LMNA |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 3 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-1156039-B1 | PYRIDAZIN-3-ONE DERIVATIVES AND MEDICINES CONTAINING THE SAME | KOWA CO (JP) | 2005-10-05 | — | — | EP | disclosed |
| US-6680316-B1 | INTERLEUKIN INHIBITORS; AUTOIMMUNE, RHEUMATIC, AND GASTROINTESTINAL DISORDERS; OSTEOPOROSIS; ANTIINFLAMMATORY, ANTIISCHEMIC, AND ANTIARTHRITIC AGENTS | KOWA CO., LTD. (JP) | 2004-01-20 | — | — | US | disclosed |
| EP-1156039-A1 | PYRIDAZIN-3-ONE DERIVATIVES AND MEDICINES CONTAINING THE SAME | Kowa Co., Ltd. (JP) | 2001-11-21 | — | — | EP | disclosed |