Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | RIPK1 | Q13546 | 1/20 | 0.42 |
| ▸ | KMT2A | Q03164 | 3/20 | 0.40 |
| ▸ | MITF | O75030 | 1/20 | 0.40 |
| ▸ | TDP1 | Q9NUW8 | 1/20 | 0.40 |
| ▸ | ALDH1A1 | P00352 | 3/20 | 0.36 |
| ▸ | MAPT | P10636 | 1/20 | 0.36 |
| ▸ | PKM | P14618 | 1/20 | 0.36 |
| ▸ | ACE | P12821 | 3/20 | 0.35 |
| ▸ | MME | P08473 | 2/20 | 0.35 |
| ▸ | NOTUM | Q6P988 | 1/20 | 0.35 |
| ▸ | XIAP | P98170 | 1/20 | 0.35 |
| ▸ | ALOX15 | P16050 | 2/20 | 0.35 |
| ▸ | GAA | P10253 | 2/20 | 0.35 |
| ▸ | NPC1 | O15118 | 1/20 | 0.35 |
| ▸ | TP53 | P04637 | 1/20 | 0.35 |
| ▸ | RAB9A | P51151 | 1/20 | 0.35 |
| ▸ | SMN1; SMN2 | Q16637 | 1/20 | 0.35 |
| ▸ | HSD17B10 | Q99714 | 1/20 | 0.35 |
| ▸ | OPRM1 | P35372 | 1/20 | 0.34 |
| ▸ | SIGMAR1 | Q99720 | 1/20 | 0.34 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL1999440 | 0.81 | RIPK1 (0.42) | RIPK1KMT2AMITFTDP1ALDH1A1 | |
| SCHEMBL1999442 | 0.81 | RIPK1 (0.42) | RIPK1KMT2AMITFTDP1ALDH1A1 | |
| SCHEMBL3148748 | 0.73 | RIPK1 (0.60) | RIPK1ACEMMEXIAP | |
| SCHEMBL3148741 | 0.73 | RIPK1 (0.60) | RIPK1ACEMMEXIAP | |
| SCHEMBL23189076 | 0.72 | MAOA (0.44) | RIPK1KMT2AMITFTDP1ALDH1A1 | |
| SCHEMBL4987572 | 0.71 | MAOA (0.43) | RIPK1KMT2AALDH1A1NOTUMALOX15 | |
| SCHEMBL15956985 | 0.71 | MAOA (0.43) | RIPK1KMT2AALDH1A1NOTUMALOX15 | |
| SCHEMBL3148112 | 0.71 | MAOA (0.43) | RIPK1KMT2AALDH1A1NOTUMALOX15 | |
| Hydrochloric Acid SCHEMBL15957112 | 0.70 | MAOA (0.42) | RIPK1KMT2AALDH1A1NOTUMALOX15 | |
| Hydrochloric Acid SCHEMBL15957113 | 0.70 | MAOA (0.42) | RIPK1KMT2AALDH1A1NOTUMALOX15 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-1554250-A1 | NOVEL LACTAMS AND USES THEREOF | AstraZeneca AB (SE) | 2005-07-20 | — | — | EP | disclosed |
| WO-2004031154-A1 | NOVEL LACTAMS AND USES THEREOF | ASTRAZENECA AB (SE) | 2004-04-15 | — | — | WO | disclosed |