Predicted protein targets (top 6)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | PIK3CA | P42336 | 20/20 | 0.53 |
| ▸ | PIK3R1 | P27986 | 8/20 | 0.53 |
| ▸ | PIK3CD | O00329 | 1/20 | 0.46 |
| ▸ | PIK3CB | P42338 | 1/20 | 0.46 |
| ▸ | PIK3CG | P48736 | 1/20 | 0.46 |
| ▸ | HDAC6 | Q9UBN7 | 1/20 | 0.45 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL625796 | 0.78 | PIK3CA (0.47) | PIK3CAPIK3CD | |
| SCHEMBL624827 | 0.78 | MAPT (0.62) | — | |
| SCHEMBL24939659 | 0.76 | AR (0.71) | PIK3CA | |
| SCHEMBL16882229 | 0.73 | PIK3CA (0.68) | PIK3CAPIK3R1PIK3CGHDAC6 | |
| SCHEMBL12463435 | 0.73 | PIK3CA (0.68) | PIK3CAPIK3R1HDAC6 | |
| SCHEMBL13316935 | 0.72 | F2RL3 (0.45) | — | |
| SCHEMBL16881776 | 0.72 | PIK3CA (0.63) | PIK3CAPIK3R1HDAC6 | |
| SCHEMBL626985 | 0.71 | PIK3CA (0.53) | PIK3CAPIK3R1PIK3CDPIK3CBPIK3CG | |
| SCHEMBL624035 | 0.71 | SMN1; SMN2 (0.40) | PIK3CAPIK3CDPIK3CBPIK3CG | |
| SCHEMBL1820803 | 0.70 | PIK3CA (0.81) | PIK3CAPIK3CBPIK3CG |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| WO-2012020217-A1 | AMINO- IMIDAZOLOTHIADIAZOLES FOR USE AS PROTEIN OR LIPID KINASE INHIBITORS | CENTRO NACIONAL DE INVESTIGACIONES ONCOLÓGICAS (CNIO) (ES) | 2012-02-16 | — | — | WO | disclosed |