Predicted protein targets (top 8)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | PIK3CA | P42336 | 20/20 | 0.53 |
| ▸ | PIK3R1 | P27986 | 8/20 | 0.53 |
| ▸ | PIK3CD | O00329 | 5/20 | 0.51 |
| ▸ | PIK3CB | P42338 | 1/20 | 0.49 |
| ▸ | HDAC6 | Q9UBN7 | 1/20 | 0.48 |
| ▸ | MTOR | P42345 | 2/20 | 0.46 |
| ▸ | PIK3CG | P48736 | 1/20 | 0.46 |
| ▸ | KCNH2 | Q12809 | 1/20 | 0.46 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL626984 | 0.80 | PIK3CA (0.48) | PIK3CAPIK3R1PIK3CDPIK3CBMTOR | |
| SCHEMBL893058 | 0.73 | PIK3CA (0.72) | PIK3CAPIK3R1PIK3CDPIK3CBHDAC6 | |
| SCHEMBL10100419 | 0.72 | ROCK2 (0.71) | PIK3CAPIK3R1PIK3CDPIK3CBHDAC6 | |
| SCHEMBL625392 | 0.72 | F2RL3 (0.42) | MTOR | |
| SCHEMBL1309601 | 0.71 | PIK3CA (0.60) | PIK3CAPIK3R1PIK3CDPIK3CBMTOR | |
| SCHEMBL625797 | 0.71 | PIK3CA (0.53) | PIK3CAPIK3R1PIK3CDPIK3CBHDAC6 | |
| SCHEMBL1309278 | 0.71 | PIK3CA (0.77) | PIK3CAPIK3R1PIK3CDPIK3CBMTOR | |
| SCHEMBL18193255 | 0.71 | PIK3CA (0.76) | PIK3CAPIK3R1PIK3CDPIK3CBMTOR | |
| SCHEMBL20458892 | 0.71 | PIK3CA (0.61) | PIK3CAPIK3R1PIK3CDPIK3CBHDAC6 | |
| SCHEMBL893372 | 0.71 | PIK3CA (0.69) | PIK3CAPIK3R1PIK3CDPIK3CBHDAC6 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| WO-2012020215-A1 | AMINO- IMIDAZOLOTHIADIAZOLES FOR USE AS PROTEIN OR LIPID KINASE INHIBITORS | CENTRO NACIONAL DE INVESTIGACIONES ONCOLÓGICAS (CNIO) (ES) | 2012-02-16 | — | — | WO | disclosed |