Predicted protein targets (top 10)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | PIK3CA | P42336 | 4/20 | 0.47 |
| ▸ | PIK3CD | O00329 | 1/20 | 0.47 |
| ▸ | LMNA | P02545 | 2/20 | 0.47 |
| ▸ | RXFP1 | Q9HBX9 | 4/20 | 0.46 |
| ▸ | FYN | P06241 | 4/20 | 0.46 |
| ▸ | PRKDC | P78527 | 1/20 | 0.46 |
| ▸ | TP53 | P04637 | 2/20 | 0.46 |
| ▸ | POLB | P06746 | 1/20 | 0.44 |
| ▸ | MAPT | P10636 | 1/20 | 0.44 |
| ▸ | THRB | P10828 | 1/20 | 0.44 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL625797 | 0.78 | PIK3CA (0.53) | PIK3CAPIK3CD | |
| SCHEMBL624826 | 0.77 | FYN (0.60) | PIK3CALMNAFYNTP53POLB | |
| SCHEMBL626984 | 0.73 | PIK3CA (0.48) | PIK3CAPIK3CD | |
| SCHEMBL624034 | 0.72 | LMNA (0.48) | LMNARXFP1TP53POLBMAPT | |
| SCHEMBL625391 | 0.71 | HASPIN (0.52) | LMNAFYNTP53POLBMAPT | |
| SCHEMBL24939659 | 0.69 | AR (0.71) | PIK3CALMNAMAPT | |
| SCHEMBL11005416 | 0.69 | RXFP1 (0.61) | LMNARXFP1TP53POLBMAPT | |
| SCHEMBL3467072 | 0.69 | PDE5A (0.59) | PIK3CAPIK3CDFYN | |
| SCHEMBL13136641 | 0.69 | CNR2 (0.71) | PIK3CAPIK3CDFYN | |
| SCHEMBL178294 | 0.67 | PIM1 (0.73) | FYN |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| WO-2012020217-A1 | AMINO- IMIDAZOLOTHIADIAZOLES FOR USE AS PROTEIN OR LIPID KINASE INHIBITORS | CENTRO NACIONAL DE INVESTIGACIONES ONCOLÓGICAS (CNIO) (ES) | 2012-02-16 | — | — | WO | disclosed |