SCHEMBL6258024

SCHEMBL6258024

CC(C)(C)OC(=O)NCc1ccc(OCc2cccc(C=O)c2)cc1

nearest known ligand 0.53

Predicted protein targets (top 16)

geneUniProtsupporting neighboursconfidence
HDAC1 Q13547 1/20 0.53
MAOA P21397 8/20 0.47
MAOB P27338 8/20 0.47
RAB9A P51151 3/20 0.47
NPC1 O15118 2/20 0.47
TDP1 Q9NUW8 1/20 0.47
GID4 Q8IVV7 1/20 0.47
ALDH1A1 P00352 1/20 0.44
POLB P06746 1/20 0.44
ALOX12 P18054 1/20 0.44
HTT P42858 1/20 0.44
SMN1; SMN2 Q16637 1/20 0.44
L3MBTL1 Q9Y468 1/20 0.43
GLS O94925 1/20 0.42
SIRT2 Q8IXJ6 1/20 0.42
SCN9A Q15858 1/20 0.42

Click a target to see other patent compounds predicted against it — the reverse direction, in place.

Similar compounds — the chemically nearest patent molecules

Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.

Compoundsimilaritytop predictedshared targets
SCHEMBL209838 0.87 GLS (0.52) HDAC1L3MBTL1GLS
SCHEMBL29952891 0.87 GLS (0.52) HDAC1L3MBTL1GLS
SCHEMBL596575 0.83 HDAC1 (0.67) HDAC1MAOBRAB9ANPC1SMN1; SMN2
SCHEMBL26508626 0.81 HDAC1 (0.56) HDAC1L3MBTL1GLS
SCHEMBL80390 0.80 NAMPT (0.47) HDAC1L3MBTL1GLS
SCHEMBL17136480 0.80 HDAC1 (0.65) HDAC1ALDH1A1SMN1; SMN2L3MBTL1
SCHEMBL208544 0.79 EPHX2 (0.57) HDAC1RAB9ANPC1TDP1L3MBTL1
SCHEMBL20132198 0.79 SIRT2 (0.59) HDAC1MAOAMAOBRAB9ANPC1
SCHEMBL26508246 0.78 MAOA (0.56) HDAC1MAOAMAOBRAB9ANPC1
SCHEMBL12188295 0.78 MAOB (0.54) HDAC1MAOAMAOBGID4SCN9A

Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.

Patent provenance — the patents this molecule appears in, and who filed them

Claimed or disclosed in 4 patents. claimed = in the patent's claims; disclosed = body only.

PatentTitleAssigneePublishedPriorityFilingCountryStatus
EP-1250317-B1 BIS-BASIC COMPOUNDS FOR USE AS TRYPTASE INHIBITORS, METHOD FOR PRODUCING THE SAME AND THEIR USE AS MEDICAMENTS BOEHRINGER INGELHEIM PHARMA (DE) 2005-09-14 EP disclosed
US-6780863-B1 TREAT INFLAMMATORY AND/OR ALLERGIC CONDITIONS BOEHRINGER INGELHEIM PHARMA GMBH & CO. KG (DE) 2004-08-24 US disclosed
EP-1250317-A2 BIS-BASIC COMPOUNDS FOR USE AS TRYPTASE INHIBITORS, METHOD FOR PRODUCING THE SAME AND THEIR USE AS MEDICAMENTS Boehringer Ingelheim Pharma KG (DE) 2002-10-23 EP disclosed
WO-2001036374-A2 BIS-BASIC COMPOUNDS FOR USE AS TRYPTASE INHIBITORS, METHOD FOR PRODUCING THE SAME AND THEIR USE AS MEDICAMENTS BOEHRINGER INGELHEIM PHARMA KG (DE) 2001-05-25 WO disclosed